Formation of excitation-inhibition balance: inhibition listens and changes its tune.

Trends Neurosci

Zilkha Neurogenetic Institute, Los Angeles, CA 90089, USA; Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

Published: October 2014


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Article Abstract

Recently, Xue, Atallah, and Scanziani reported that excitation/inhibition ratios across cortical pyramidal neurons are equalized by activity-dependent modulations of parvalbumin-neuron mediated feedforward inhibition. Their results raise questions about the developmental formation of this excitation-inhibition balance and the potential activity-dependent synaptic plasticity rules that mediate this process.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189014PMC
http://dx.doi.org/10.1016/j.tins.2014.09.001DOI Listing

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