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It has been suggested that the time spent at a high stroke volume (SV) is important for improving maximal cardiac function. The aim of this study was to examine the effect of recovery intensity on cardiovascular parameters during a typical high-intensity interval training (HIIT) session in fourteen well-trained cyclists. Oxygen consumption (VO2), heart rate (HR), SV, cardiac output (Qc), and oxygenation of vastus lateralis (TSI) were measured during a HIIT (3×3-min work period, 2 min of recovery) session on two occasions. VO2, HR and Qc were largely higher during moderate-intensity (60%) compared with low-intensity (30%) (VO2, effect size; ES = +2.6; HR, ES = +2.8; Qc, ES = +2.2) and passive (HR, ES = +2.2; Qc, ES = +1.7) recovery. By contrast, there was no clear difference in SV between the three recovery conditions, with the SV during the two active recovery periods not being substantially different than during exercise (60%, ES = -0.1; 30%, ES = -0.2). To conclude, moderate-intensity recovery may not be required to maintain a high SV during HIIT. Key pointsModerate-intensity recovery periods may not be necessary to maintain high stroke volume during the exercise intervals of HIIT.Stroke volume did not surpass the levels attained during the exercise intervals during the recovery periods of HIIT.The practical implication of these finding is that reducing the intensity of the recovery period during a HIIT protocol may prolong the time to exhaustion, potentially allowing completion of additional high-intensity intervals increasing the time accumulated at maximal cardiac output.
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Neurol Sci
September 2025
School of Public Health, Shaanxi University of Chinese Medicine, Shaanxi, 712046, Xianyang, P. R. China.
Background: Stroke persists as the second leading global cause of mortality and disability. We analyzed G20 nations using Global Burden of Disease (GBD) 2021 data (1990-2021) to provide a new perspective.
Methods: We obtained age-standardized rates (ASR) of stroke mortality, incidence, prevalence, and YLLs (years of life lost) across G20 nations.
Eur J Clin Invest
September 2025
Liverpool Centre for Cardiovascular Science, at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, UK.
Background: Patients with atrial fibrillation (AF) with end-stage renal failure on renal replacement therapy are at high risk of stroke and bleeding, but the optimal oral anticoagulation (OAC) strategy is uncertain. To investigate the most effective OAC therapy for patients with AF on long-term dialysis.
Methods: PubMed, EMBASE and Web of Science databases were systematically searched from inception to 9 October 2024 to identify relevant studies on OAC strategy for patients with AF on long-term dialysis.
J Integr Neurosci
August 2025
Department of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, 150001 Harbin, Heilongjiang, China.
Background And Purpose: Ciprofol, a novel intravenous anesthetic, has been shown to exert protective effects against ischemic stroke, a leading cause of death and disability; however, its molecular mechanisms remain unclear. This study aimed to explore the molecular mechanisms underlying the neuroprotective effects of ciprofol using metabolomics.
Methods: This study used a middle cerebral artery occlusion (MCAO) rat model to simulate cerebral ischemia-reperfusion injury (CIRI).
Front Microbiol
August 2025
Emergency Department, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.
Introduction: Acute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS.
Methods: In this study, we investigated alterations in gut microbiota composition and metabolomic profiles in AS patients using 16S rRNA sequencing and untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics technology.
Am J Prev Cardiol
September 2025
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Chinese Academy of Medical Science and Peking Union Medical College, No. 167, North Lishi Road, Xicheng District, Beijing 100037, China.
Background: The Framingham Risk Score for Cardiovascular Disease (FRSCVD), based on the Framingham Heart Study, serves as a foundation for many prediction models. However, its applicability in predicting the long-term prognosis of patients experiencing myocardial infarction with nonobstructive coronary arteries (MINOCA) remains uncertain.
Methods: A cohort of 1158 MINOCA patients was enrolled and stratified into three groups based on 10-year FRSCVD risk.