Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Context: Matrix metalloproteinases are involved in atherosclerosis and plaque vulnerability.
Objective: To investigate serum levels and genetic polymorphisms of matrix metalloproteinases (MMPs) -1, -3 and -9 in patients submitted to carotid endarterectomy.
Methods: Genetic polymorphisms were evaluated using polymerase chain reaction (PCR-RFLP); serum levels were measured using ELISA; histological sections were stained with Picrosirius Red to analyze the fibrous cap thickness, lipid core and collagen content and with hematoxylin--eosin to detect the presence of intraplaque hemorrhage.
Results: MMP-9 serum levels were significantly higher in patients with a thinner fibrous cap (p = 0.033) or acute or recent intraplaque hemorrhage (p = 0.008) on histology, as well as in patients with previous stroke (p = 0.009) or peripheral vascular disease (p = 0.049). No consistent associations were observed between different MMP genotypes and fibrous cap thickness, lipid core, collagen content or intraplaque hemorrhage.
Conclusions: MMP-9 serum levels were consistently associated with markers of carotid atherosclerosis and lesion vulnerability, whereas specific MMP genotypes were not.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/1354750X.2013.866165 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gut health and physiological aspects of broiler chicken fed zeolite as a dietary supplement: its effect on growth, cecal microbiota and digesta viscosity, digestive enzymes, carcass traits, blood constituents and antioxidant parameters.
BMC Vet Res
September 2025
Department of Poultry Production, Faculty of Agriculture, Fayoum University, Fayoum, 63514, Egypt.
This study investigated the impact of dietary zeolite supplementation on growth, cecal microbiota and digesta viscosity, digestive enzymes, carcass traits, blood constituents, and antioxidant parameters of broilers. A completely randomized design was used with 240 one-day-old broiler chicks randomly assigned to three dietary treatments (0%, 1.5%, and 3% zeolite as a feed additive) with four replicates of 20 chicks each.
View Article and Find Full Text PDFExtreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport.
Immun Ageing
September 2025
Department of Biomedical Data Sciences, Molecular Epidemiology, LUMC, Leiden, The Netherlands.
The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay and liquid chromatography-mass spectrometry-based proteomics we explored the plasma proteins associating with the difference in 100 extreme scoring individuals selected from two large population cohorts, the Leiden Longevity Study (LLS) and the Rotterdam Study (RS), and discordant monozygotic twin pairs from the Netherlands Twin Register (NTR).
View Article and Find Full Text PDFClinical characteristics of IgG4-related lung disease: a single-center based experience.
Clin Rheumatol
September 2025
The First College of Clinical Medical Science, Three Gorges University, Yichang, China.
Background: IgG4-related lung disease (IgG4-RLD) is a rare autoimmune condition. This study aims to systematically analyze the clinical characteristics of IgG4-RLD to enhance clinicians' awareness and improve patient outcomes.
Methods: This retrospective analysis investigates the clinical data of 20 patients diagnosed with IgG4-RLD at the Yichang Central People's Hospital between January 2019 and April 2025.
Serum progesterone variability on embryo transfer day in hormone replacement therapy cycles using intramuscular injections during frozen embryo transfers.
J Assist Reprod Genet
September 2025
Bahçeci Fulya IVF Center, Infertility Clinic, Istanbul, Turkey.
Purpose: To assess the intra-individual variability of serum progesterone (P) levels on embryo transfer (ET) day, when the same dose of intramuscular progesterone (IM-P) was used in two consecutive hormone replacement therapy (HRT) frozen embryo transfer (FET) cycles.
Methods: A total of 75 patients undergoing two consecutive HRT-FET cycles in one year performed at Bahceci Ankara IVF Center between November 2019 and February 2022 were retrospectively analyzed. Serum P levels were measured at the 117th-119th hours of support by a single laboratory.
Gut-derived indole propionic acid alleviates liver fibrosis by targeting profibrogenic macrophages via the gut‒liver axis.
Cell Mol Immunol
September 2025
Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Gut-derived metabolites are essential for liver fibrogenesis. The aim of this study was to determine the alteration of indole-3-propionic acid (IPA), a crucial tryptophan metabolite, in liver fibrosis and delineate the roles of enterogenic IPA in fibrogenesis. In the present study, metabolomics assays focused on tryptophan metabolism were applied to explore the decreased levels of IPA in the feces and serum of cirrhotic patients, as well as in the feces and portal vein serum of fibrotic mice.
View Article and Find Full Text PDF