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A new fluorescent receptor 1,1'-(4-methylbenzene-1,3-diyl)bis[3-(2-sulfanylphenyl)urea] (1) has been designed and synthesized. The receptor showed excellent selectivity for Fe(3+) in DMSO/H2O (8:2, v/v) solvent system over other commonly coexistent metal ions. The binding constant (Ka) of receptor with Fe(3+) was calculated to be 11,250 M(-1), 12,970 M(-1) and 12,970 M(-1) using Benesi-Hildebrand, Scatchard and Connor plot, respectively. The experimental results have been further supported by the detailed DFT calculations.
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http://dx.doi.org/10.1016/j.saa.2013.11.007 | DOI Listing |
J Virol
September 2025
Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Programmed cell death (PCD) refers to a regulated cellular process involving a cascade of biochemical reactions and molecular mechanisms, commonly including apoptosis, necroptosis, and pyroptosis. Ferroptosis is a recently identified form of PCD distinguished by its dependence on iron. Emerging evidence underscores the significance of ferroptosis in viral infections; however, its role in Pseudorabies virus (PRV) infection, an enveloped double-stranded DNA virus belonging to the Alphaherpesvirinae subfamily, remains poorly understood.
View Article and Find Full Text PDFACS Omega
August 2025
Department of Orthopaedics, The First Affiliated Hospital of Jinan University, Guangzhou 510000, China.
Osteoporosis (OP), characterized by reduced bone mass and microstructural deterioration, poses a significant global health burden. Current therapies, such as bisphosphonates (e.g.
View Article and Find Full Text PDFActa Biomater
September 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 18 Shuangqing Rd, Haidian District, Beijing, 100085, China. Electronic address:
Ferrotherapy has risen as a promising therapeutic approach for triple-negative breast cancer (TNBC); however, its potency is frequently compromised due to tumor cells' ability to evade ferroptosis via various resistance pathways and insufficient immunogenicity. To overcome these limitations, we have engineered a calcium phosphate-mineralized ferroptosis inducer nanoplatform, termed Lf-PEG-CaP@iFSP1-Brequinar-Erastin-Fe-TA (LP-CaP@iBEFT), designed to augment ferroptosis by simultaneously targeting three key pathways: glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), and dihydroorotate dehydrogenase (DHODH). Once internalized and reached the acidic tumor microenvironment (TME), the nanoplatform discharges its therapeutic payloads, comprising inhibitors of FSP1 (iFSP), brequinar, erastin, and iron ions.
View Article and Find Full Text PDFJ Control Release
August 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 510632, China; National Engineering Research Center of Genetic Me
Ferroptosis therapy shows potential for lung tumor treatment, but precise accumulation of reactive oxygen species (ROS) remains a challenge. A lysosome-hijacking strategy was developed, aiming to induce ROS spread from lysosomes to the entire cell. The key is delivering a ROS inducer to the lysosome for rapid and targeted ROS generation.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Chemodynamic therapy (CDT), leveraging intracellular iron ions (Fe) and hydrogen peroxide (HO), is a highly selective therapeutic strategy with significant potential. However, its clinical application is currently hindered by the limited catalytic activity of transition metal ions and insufficient HO supply. In this study, we present a novel and effective CDT approach using an Fe single-atom nanozyme (Fe-SAE) to deliver dihydroartemisinin (DHA), a first-line antimalarial drug.
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