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Ionic current fluctuations in graphene nanopore devices are a ubiquitous phenomenon and are responsible for degraded spatial and temporal resolution. Here, we descriptively investigate the impact of different substrate materials (Si and quartz) and membrane thicknesses on noise characteristics of graphene nanopore devices. To mitigate the membrane fluctuations and pin-hole defects, a SiNx membrane is transferred onto the substrate and a pore of approximately 70 nm in diameter is perforated prior to the graphene transfer. Comprehensive noise study reveals that the few layer graphene transferred onto the quartz substrate possesses low noise level and higher signal to noise ratio as compared to single layer graphene, without deteriorating the spatial resolution. The findings here point to improvement of graphene based nanopore devices for exciting opportunities in future single-molecule genomic screening devices.
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http://dx.doi.org/10.1088/0957-4484/24/49/495503 | DOI Listing |
Microb Genom
September 2025
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
Amplicon sequencing is a popular method for understanding the diversity of bacterial communities in samples containing multiple organisms as exemplified by 16S rRNA sequencing. Another application of amplicon sequencing includes multiplexing both primer sets and samples, allowing sequencing of multiple targets in multiple samples in the same sequencing run. Multiple tools exist to process the amplicon sequencing data produced via the short-read Illumina platform, but there are fewer options for long-read Oxford Nanopore Technologies (ONT) sequencing, or for processing data from environmental surveillance or other sources with many different organisms.
View Article and Find Full Text PDFPNAS Nexus
September 2025
Department of Chemical and Biomedical Engineering, University of Missouri, Columbia, MO 65211, USA.
DNA data storage is a promising alternative to conventional storage due to high density, low energy consumption, durability, and ease of replication. While information can be encoded into DNA via synthesis, high costs and the lack of rewriting capability limit its applications beyond archival storage. Emerging "hard drive" strategies seek to encode data onto universal DNA templates without de novo synthesis, using methods such as DNA nanostructures and base modifications.
View Article and Find Full Text PDFJ Colloid Interface Sci
August 2025
School of Physics and Astronomy, Beijing Normal University, Beijing 100875, China. Electronic address:
Phase change materials (PCMs)-integrated solar-thermal-electric generators (STEGs) have emerged as a promising platform for sustainable solar energy harvesting, yet faces critical challenges including liquid phase instability, insufficient photothermal efficiency, and limited thermoelectric output. Herein, we engineered hierarchical photonic confinement through the assembly of plasmonic CuS nanoparticles, broadband-absorbing MoS nanosheets, and porous bacterial cellulose (BC). In this tripartite architecture, BC matrix provides robust structural integrity and enhances heat transfer via its 3D interconnected nanoporous structure; MoS nanosheets enable extended photon harvesting across the ultraviolet to near-infrared spectrum; CuS nanoparticles amplify near-field optical effects through localized surface plasmon resonance.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Jiangsu Key Laboratory for Design and Manufacture of Precision Medicine Equipment, School of Mechanical Engineering, Southeast University, Nanjing 211189, China.
Nanofluidic memristors have become a hotspot in neuromorphic computing research due to their potential in modeling biological synaptic functions. However, many existing nanofluidic memristors rely on electrochemical or electric field-driven mechanisms, failing to directly mimic the properties of mechanically gated ion channels (e.g.
View Article and Find Full Text PDFInt J Biol Macromol
August 2025
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.
Guar gum (GG), a biodegradable and biocompatible polysaccharide, exhibits limited stability in its hydrogel form. To overcome this, semi-interpenetrating polymeric networks (semi-IPN) were engineered by synthesizing a Diels-Alder (DA) polymer (Polymer 1) from a difurfuryl monomer (Di-Fur, derived from L-tartaric acid) and a dimaleimide (Di-Mal, from 1,8-diamine-3,6-dioxaoctane) within a GG solution (Polymer 2). Controlled crosslinking was achieved by introducing a novel trifunctional crosslinker (Tri-Fur), containing three furan rings and synthesized from D-ribonolactone.
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