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Roots are very sensitive to hypoxia and adapt effectively to a reduced availability of oxygen in the soil. However, the site of the root where oxygen availability is sensed and how roots acclimate to hypoxia remain unclear. In this study, we found that the root apex transition zone plays central roles in both sensing and adapting to root hypoxia. The exposure of cells of the root apex to hypoxia is sufficient to achieve hypoxic acclimation of the entire root; particularly relevant in this respect is that, of the entire root apex, the transition zone cells show the highest demand for oxygen and also emit the largest amount of nitric oxide (NO). Local root apex-specific oxygen deprivation dramatically inhibits the oxygen influx peak in the transition zone and simultaneously stimulates a local increase in NO emission. The hypoxia-induced efflux of NO is strictly associated with the transition zone and is essential for hypoxic acclimation of the entire root.
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http://dx.doi.org/10.1093/pcp/pcs034 | DOI Listing |
J Dent
September 2025
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases; Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.. Electronic address:
Objectives: This retrospective study evaluates alveolar bone remodeling patterns and their association with incisor displacement in adults undergoing clear aligner therapy with premolar extractions for Class II malocclusion correction.
Methods: Cone-beam computed tomography (CBCT) scans of 38 maxillary and 37 mandibular incisors were analyzed. Displacement vectors for four anatomical landmarks (cusp tip [C], root apex [R], root neck midpoint [M], labial cementoenamel junction [L]) were quantified.
World J Methodol
December 2025
Department of Periodontics, Sudha Rustagi College of Dental Sciences and Research, Faridabad 121002, Haryāna, India.
Background: Advanced materials and techniques are used to successfully manage the apexification of immature teeth with open apices. The use of mineral trioxide aggregate (MTA), bioceramic sealers, and sodium hypochlorite (NaOCl), combined with internal heating and ultrasonic activation, ensures that canals are cleaned, disinfected, and sealed properly. Magnification devices, such as dental operating microscopes (DOM), provide precise visualization for accurate material placement, while the micro apical placement system ensures void-free MTA delivery.
View Article and Find Full Text PDFNiger J Clin Pract
August 2025
Department of Endodontics, Harran University, Şanlıurfa, Turkey.
Background: Pregnancy and parity induce physiologic adaptations in maternal calcium and bone metabolism, yet their specific effects on mandibular trabecular architecture remain insufficiently characterized. Evidence on craniofacial bone across parity is limited and conflicting, underscoring the need to clarify whether parity relates to mandibular bone quality.
Aims: The main aim of this study was to evaluate the effect of parity on mandibular bone architecture using fractal dimension analysis (FDA).
J Oral Maxillofac Surg
August 2025
Department Head, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University; Department Head, Department of Oral Surgery, School & Hosp
Background: Oroantral communication (OAC) is a perforation between the oral cavity and maxillary sinus, commonly occurring after maxillary posterior tooth extraction. The role of imaging in identifying high-risk cases remains unclear.
Purpose: The study aimed to estimate the association between periapical and cone beam computed tomography (CBCT) imaging with OAC exposure during maxillary posterior tooth extraction and evaluate the necessity of CBCT in clinical decision-making.
Bone
August 2025
School of Dentistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada; Department of Oral Biological & Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada. Electronic address:
This study presents a method development and evaluation framework for assessing longitudinally the dynamic alveolar bone changes in a murine periodontal injury model using 3D Slicer software. Accurate and reproducible measurement of bone loss is crucial for periodontal research, yet traditional two-dimensional (2D) histological approaches lack the ability to capture three-dimensional (3D) alterations, while inconsistencies in image alignment, region of interest (ROI) selection, and segmentation have limited the widespread adoption of 3D micro-CT analysis in small animal models. Here, we present a standardized workflow, incorporating defined criteria for ROI selection, scan alignment, and segmentation suitable for live micro-CT scanning.
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