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Three structurally simple thiourea derivatives 1-3 were prepared, and their chromogenic behaviors toward various anions were investigated in aqueous solution. Among them 1 showed good sensitivity and selectivity for cyanide ion and also can distinguish it from other anions by different color changes. Besides that, the receptor 1 has a sensitive detection limit (1.27 μM) for cyanide ion accordingly it can be used as a colorimetric sensor for the determination of cyanide ion. The use of the test strip of sensor 1 to detect cyanide ion was also reported.
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http://dx.doi.org/10.1016/j.saa.2011.04.087 | DOI Listing |
Int J Nanomedicine
September 2025
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Introduction: Oral squamous cell carcinoma (OSCC) has a poor prognosis due to its immunosuppressive tumor microenvironment (TME), in which tumor-associated macrophages (TAMs) play a pivotal role in promoting disease progression and therapeutic resistance. This study examines whether Prussian blue nanoparticles (PB NPs) could reprogram TAMs and block tumor-stroma communication in OSCC.
Methods: PB NPs were synthesized using polyvinylpyrrolidone-assisted coprecipitation and characterized by transmission electron microscopy, dynamic light scattering, and UV-Vis spectroscopy.
Int J Nanomedicine
September 2025
School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, People's Republic of China.
Purpose: This study aimed to develop a composite nanozyme system (Au/PB-Ce6-HA) based on gold nanoparticles (AuNPs) and Prussian blue nanoparticles (PBNPs) to combat tumor hypoxia and insufficient endogenous hydrogen peroxide (HO) deficiency, thus enhancing the efficacy of sonodynamic therapy (SDT) and starvation therapy for liver cancer.
Methods: The Au/PB-Ce6-HA system was constructed by in situ embedding AuNPs on PBNPs, loading the sonosensitizer Chlorin e6 (Ce6), and surface-coating with thiolated hyaluronic acid (HA-SH). The system was evaluated both in vitro and in vivo to assess its ability to catalyze glucose to generate HO, decompose HO to produce oxygen, and generate highly toxic reactive oxygen species (ROS) under ultrasound irradiation.
Water Res
September 2025
Key Laboratory of Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, College of Environment and Ecology, Chongqing University, Chongqing, 400045, PR China.
The advanced degradation of ferricyanide ([Fe(CN)₆]³⁻) in industrial wastewater faces dual bottlenecks of self-acidification-induced hydrogen cyanide (HCN) release and inefficient decomplexation. This study innovatively constructs an alkaline UV/Peracetic Acid (PAA) synergistic system and systematically elucidates its triple action mechanism: (1) UV irradiation at 254 nm directly drives ligand-to-metal charge transfer (LMCT) excitation of ferricyanide, achieving efficient Fe-CN bond breaking (Φ₂₅₄ = 0.235-0.
View Article and Find Full Text PDFZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
August 2025
Physical and Chemical Testing Institute, Taizhou Municipal Center for Disease Control and Prevention (Taizhou Health Supervision Institution), Taizhou 318000, China.
To establish a method for determination of two derivatives of cyanide in biomaterials by headspace gas chromatography mass spectrometry. In February 2024, blood and urine samples were placed in headspace sampling vials. Phosphoric acid, or phosphoric acid and chloramine T solution, was added respectively to derivatize cyanide into hydrogen cyanide or cyanogen chloride.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
August 2025
Department of Advanced Organic Materials Engineering, Chungnam National University, Yuseong-gu, Daejeon 34134, South Korea. Electronic address:
A new colorimetric and fluorimetric probe PBT, for the efficient recognition of cyanide ion was synthesized and characterized; the sensing properties were analyzed and used for various real-time applications. The probe consists of a D-π-A conception with a donor unit of phenothiazine and an acceptor unit of benzothiazole to make a molecule for the ease of charge transfer transition. The mechanism of recognition is confirmed by H NMR and HRMS spectral analysis.
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