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http://dx.doi.org/10.1002/cbic.201000259 | DOI Listing |
Adv Sci (Weinh)
September 2025
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, China.
Enfumafungin-type antibiotics, represented by enfumafungin and fuscoatroside, constitute a distinct class of fungi-derived fernane-type triterpenoids renowned for their potent antifungal activity. Notably, ibrexafungerp, a semi-chemically synthesized analogue of enfumafungin, has recently received approval as a novel antifungal drug. Thus, reconstituting the heterologous biosynthesis of enfumafungin holds great significance, as it offers a promising route for high-level production.
View Article and Find Full Text PDFBiotechnol Biofuels Bioprod
August 2025
Metabolic Engineering Group. Department of Microbiology and Genetics, Universidad de Salamanca, Salamanca, Spain.
Gangliosides are essential glycosphingolipids critical in neurodevelopment and cell signaling. Traditionally sourced from animal tissues, their production raises ethical concerns and faces challenges in scalability and cost. Chemoenzymatic methods have emerged as alternatives but lack flexibility and broad industrial applicability of microbial systems.
View Article and Find Full Text PDFImmun Inflamm Dis
August 2025
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Background: Vascularized composite allotransplantation (VCA) is a potential treatment for extensive injuries that replaces defects like-with-like, however allografts are immune-rejectable.
Methods: This study developed in vitro thymic organoids and examined whether donor-derived HSCs could be educated in vivo into T lymphocytes via central tolerance. TECs, TMCs, and HSCs from C57BL/7 (CD45.
mSystems
August 2025
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
KIAC is a novel acetogen isolated from cattle feces that exhibits rapid CO utilization. To investigate the molecular basis of this phenotype, we performed a comprehensive multi-omics analysis, including Genome-seq, RNA-seq, dRNA-seq, and Term-seq, to map its transcriptome architecture. We identified 2,158 transcription start sites and 2,275 transcript 3' ends, enabling high-resolution reconstruction of the transcriptional landscape and associated regulatory features.
View Article and Find Full Text PDFPlants (Basel)
July 2025
Houji Laboratory in Shanxi Province, College of Life Sciences, Shanxi Agricultural University, Jinzhong 030801, China.
The SCARECROW (SCR) transcription factor governs cell-type patterning in plant roots and Kranz anatomy of leaves, serving as a master regulator of root and shoot morphogenesis. Foxtail millet (), characterized by a compact genome, self-pollination, and a short growth cycle, has emerged as a C model plant. Here, we revealed two paralogs in foxtail millet- and -which exhibit high sequence conservation with (), (), and (), particularly within the C-terminal GRAS domain.
View Article and Find Full Text PDF