Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Novel 2[small alpha]-methyl-, 2[small alpha]-(3-hydroxypropyl)- and 2[small alpha]-(3-hydroxypropoxy)-substituted 25-dehydro-1[small alpha]-hydroxyvitamin D-26,23-lactone derivatives were efficiently synthesized Reformatsky type allylation and palladium-catalyzed alkenylative cyclization processes, and their biological activities were evaluated. Introducing functional groups into the 2[small alpha]-position of the vitamin D-26,23-lactones resulted in remarkable enhancement of their antagonistic activity on vitamin D receptor (VDR).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b311107e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endophytic Fusarium isolates from Ceratozamia mirandae enhance tomato growth, suppress pathogenic fungi, and induce protection against Botrytis cinerea.
Rev Argent Microbiol
September 2025
IPICYT, División de Biología Molecular, Laboratorio de Genómica Funcional y Comparativa, Camino a la Presa San José 2055, Col. Lomas 4 Sección, 78216 San Luis Potosí, SLP, Mexico.
Fungal diseases in agricultural crops cause economic losses, with chemical control being the conventional method to manage them. However, this approach negatively impacts both the environment and human health. This study focused on endophytic fungi isolated from the roots of Ceratozamia mirandae in the Mexican locality of Juan Sabines (Villa Corzo, Chiapas).
View Article and Find Full Text PDFResponses of Soil Bacteria Communities to Organic Material Application and Their Antagonistic Activity against Diaporthe destruens Causing Sweet Potato Foot Rot Disease.
Microbes Environ
September 2025
Research Field in Agriculture, Agriculture Fisheries and Veterinary Medicine Area, Kagoshima University.
Sweet potato foot rot disease caused by Diaporthe destruens (formerly Plenodomus destruens) severely affects the yield and quality of sweet potatoes. To gain basic knowledge on regulating the pathogen using indigenous soil bacteria, the following organic materials were applied to potted soils collected from a sweet potato field contaminated with D. destruens: Kuroihitomi (compost made from shochu waste and chicken manure), Soil-fine (material made by adsorbing shochu waste on rice bran), and rice bran.
View Article and Find Full Text PDFMulti-Omics Profiling Unveils Antifungal Secondary Metabolites Mediating LQ's Biocontrol Efficacy Against .
Phytopathology
September 2025
308 Plant protection collegenorthwest a&F universityyangling, shaanxi, China, 712100;
is a significant phytopathogen in both pre- and postharvest stages of fruit development and storage. The development of environmentally-friendly biological control agents has attracted increasing research interest. In this study, we characterized a fungal strain ( LQ) that strongly inhibits .
View Article and Find Full Text PDFLong-term compost fertilization enhanced soil disease suppressiveness by fostering interactions between root exudates and the rhizosphere microbiome.
Microbiol Res
September 2025
College of Resources and Environmental Science, State Key laboratory of nutrient use and management, China Agricultural University, Beijing 100193, China. Electronic address:
A comprehensive understanding of the interplay between agricultural practices and the rhizosphere microbiome particularly the role of root exudates is essential for harnessing microbial potential in sustainable agriculture. In this study, we investigated how disease-suppressive soil alters root exudate profiles in pepper plants and how these elevated exudates influence rhizosphere microbiome assembly and modulate the antagonistic activity of Bacillus methylotrophicus 400 (BM400) against Phytophthora capsici. GC-MS analysis identified distinct compositional profiles of root exudates in the disease-suppressive soil, with marked enrichment of seven compounds.
View Article and Find Full Text PDFTaGW2-TaVOZ1 module regulates wheat salt tolerance via both E3 ligase-dependent and -independent pathways.
Sci Adv
September 2025
State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, China.
Wheat production is limited by the rapid expansion of salinized arable land worldwide. Identification of the molecular mechanisms that underlie the salt stress response is of great importance. Here, we uncovered the NAC-type transcription factor, TaVOZ1, as a positive regulator of wheat salt tolerance.
View Article and Find Full Text PDF