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Axisymmetric fundamental solutions that are applied in the consolidation calculations of a finite clay layer with impeded boundaries were derived. Laplace and Hankel integral transforms were utilized with respect to time and radial coordinates, respectively in the analysis. The derivation of fundamental solutions considers two-boundary value problems involving unit point loading and ring loading in the vertical. The solutions are extended to circular distributed and strip distributed normal load. The computation and analysis of settlements, vertical total stress and excess pore pressure in the consolidation layer subject to circular loading are presented.
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http://dx.doi.org/10.1631/jzus.2003.0393 | DOI Listing |
Biochim Biophys Acta Rev Cancer
September 2025
Department of Internal Medicine Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Number 440, Ji Yan Road, Jinan 250117, China. Electronic address:
Antibody-drug conjugates (ADCs), one of the emerging developing classes of antitumor drugs, have transformed the therapeutic paradigm in oncology. It stands out due to its properties of boasting the strength of both chemotherapy and targeted therapy. In small cell lung cancer (SCLC), ADC has also demonstrated its potential and appealing effect.
View Article and Find Full Text PDFWater Res
September 2025
Key Lab of Groundwater Resources and Environment Ministry of Education, Jilin University, Changchun 130021, China; Jilin Provincial Key Laboratory of Water Resources and Water Environment, Jilin University, Changchun 130021, China; National and Local Joint Engineering Laboratory for Petrochemical Co
As an abundant natural mineral, pyrite presents a highly promising solution for sustainable groundwater remediation, owing to its distinct electron transfer properties. However, research on pyrite's remediation capabilities has often focused on isolated mechanisms, neglecting the complex interplay between the mineral's properties, the environmental matrix, and interfacial processes, thereby limiting comprehensive understanding of its efficacy and constraints. Herein, an integrated "mechanism-application-sustainability" framework is proposed to bridge this knowledge gap.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
School of Environmental Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 611756, China; Sichuan Engineering Research Center for Pollution Control in Rail Transit Engineering, Chengdu, Sichuan 611756, China; Sichuan International Science and Technology Cooperation base for Int
In alpine meadow regions, macropore flow is a critical but inadequately understood pathway for antibiotic transport. The complex relationship between macropore structure, flow dynamics, and solute properties presents a significant research gap. Methodological limitations hinder the accurate characterization of solute migration mechanisms due to complex macropore structures.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
Department of Biomedical Engineering, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210023, China.
Heat shock protein 70 (HSP70) represents a critical barrier to effective mild-temperature photothermal therapy (MPTT), limiting its clinical utility in aggressive cancers like triple-negative breast cancer (TNBC). While small interfering RNA (siRNA)-mediated HSP70 suppression offers a promising solution, optimal timing for this therapeutic combination remains unexplored. Here, it is demonstrated that precisely timed administration significantly enhances MPTT efficacy through systematic temporal characterization of HSP70 expression dynamics.
View Article and Find Full Text PDFAdv Mater
September 2025
School of Chemistry and Biochemistry, School of Materials Science and Engineering, Center for Organic Photonics and Electronics, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Molecular spin systems that can be chemically tuned, coherently controlled, and readily integrated within devices remain central to the realization of emerging quantum technologies. Organic high-spin materials are prime candidates owing to their similarity in electronic structure to leading solid-state defect-based systems, light element composition, and the potential for entanglement and qubit operations mediated through spin-spin exchange. However, the inherent instability of these species precludes their rational design, development, and application.
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