Evaluating the Role of Multimodal Imaging in the Diagnosis of Cardiac Amyloidosis and Hypertrophic Cardiomyopathy.

Objective: The objective of this study is to examine the evolving cardiac characteristics of patients with cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) by integrating multimodal imaging techniques, including conventional echocardiography, strain echocardiography, and cardiac magnetic resonance imaging.

Methods: A retrospective study was conducted, comprising 38 patients with CA, 20 patients with HCM, and 16 healthy individuals in the control group. Statistical analyses were conducted to assess conventional and strain echocardiography parameters across these groups.

Evaluation of Left Ventricular Function in Patients With Severe Aortic Stenosis Utilizing Automated Cardiac Motion Quantitation Techniques.

Objective: The objective of this study is to explore the patterns of alteration in left ventricular systolic function among patients with severe aortic stenosis (SAS) through the application of automatic myocardial motion quantification (aCMQ) techniques. Furthermore, we seek to ascertain dependable quantitative markers for the assessment of impaired left ventricular function in patients with SAS and an ejection fraction (EF) ≥ 60%.

Methods: Seventy patients who underwent echocardiography and received a diagnosis of severe aortic stenosis (SAS) in the hospital from November 2021 to August 2022 were selected for the SAS group and categorized into three subgroups based on ejection fraction (EF)-SAS group with EF ≥ 60%, SAS group with EF ranging from 50% to 59%, and SAS group with EF < 50%.

Self-assembly of peptide nanomaterials at biointerfaces: molecular design and biomedical applications.

Self-assembly is an important strategy for constructing ordered structures and complex functions in nature. Based on this, people can imitate nature and artificially construct functional materials with novel structures through the supermolecular self-assembly pathway of biological interfaces. Among the many assembly units, peptide molecular self-assembly has received widespread attention in recent years.

Pediatric Mycotic Pseudoaneurysm of the Ascending Aorta: A Case Report.

Mycotic pseudoaneurysm of the ascending aorta is extremely uncommon, particularly in children with no prior cardiac surgery or trauma. We report a rare case of a mycotic pseudoaneurysm of the ascending aorta in a 2-year-old girl with no history of cardiac surgery. Investigations revealed a methicillin-resistant infection and significant pericardial effusion in the child who presented with persistent fever and altered mental state.

A Case of Postnatal Aortic Arch Atresia.

Background: Aortic arch atresia is a rare congenital cardiac defect that may occur after birth. Pregnant women with gestational diabetes mellitus may increase the risk of aortic arch atresia in newborns after birth.

Case Description: A 16-day-old infant was referred to our hospital on the 15th postnatal day after an interrupted or atretic aortic arch was discovered.

Sonoactivated Cascade Fenton Reaction Enhanced by Synergistic Modulation of Electron-Hole Separation for Improved Tumor Therapy.

Chemodynamic therapy (CDT) is an emerging targeted treatment technique for tumors via the generation of highly cytotoxic hydroxyl radical (·OH) governed by tumor microenvironment-assisted Fenton reaction. Despite high effectiveness, it faces limitations like low reaction efficiency and limited endogenous H O , compromising its therapeutic efficacy. This study reports a novel platform with enhanced CDT performance by in situ sono-activated cascade Fenton reaction.

Desulfonylative Electrocarboxylation with Carbon Dioxide.

Electrocarboxylation of organic halides is one of the most investigated electrochemical approaches for converting thermodynamically inert carbon dioxide (CO) into value-added carboxylic acids. By converting organic halides into their sulfone derivatives, we have developed a highly efficient electrochemical desulfonylative carboxylation protocol. Such a strategy takes advantage of CO as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.

Photothermal-Promoted Morphology Transformation Monitored by Photoacoustic Imaging.

The construction of the nanoassembly has been demonstrated to improve the performance of bioactive molecules, but the control of the morphology of nanomaterials still remains a tremendous challenge. Herein, a photothermal-promoted morphology transformation (PMT) strategy is developed to accelerate the formation of nanomaterials for improving the biological performance of drug molecules. Compared with the spontaneous process, the rate of transformation increases by ∼4 times in the PMT process.

Low threshold 2nd-order random lasing of a fiber laser with a half-opened cavity.

In this paper, we reported the realization of 2nd-order random lasing in a half-opened fiber cavity, which is formed by a FBG with central wavelength at the 1st-order Raman Stokes wavelength and a single-mode fiber (SMF) performing as a random distributed feedback mirror. Using this proposed method, the threshold of 1st-order (2nd-order) random lasing is reduced to 0.7 (2.

Three new compounds from endophytic fungus L10 of Cephalotaxus hainanensis.

Three new compounds, 4-hydroxyphenethyl-2'-hydroxypropanoate (1), 6-(1',2'-dimethyloxiran-1'-yl)-4-methoxy-3-methyl-2H-pyran-2-one (2), 6-(1-hydroxyethyl)-4-methoxy-3-methyl-2H-pyran-2-one (3), along with the two known compounds, nectriapyrone (4) and wermopyrone (5), have been isolated from the endophytic fungus of Cephalotaxus hainanensis. Their structures were determined on the basis of chemical and spectroscopic methods.

Construction of a long cyclodextrin-based bis(molecular tube) from bis(polypseudorotaxane) and its capture of C60.

The preorganized bis(polypseudorotaxane) (approximately 20 nm long) formed by the multiple metallo-bridged poly(beta-cyclodextrin)s has been successfully converted to the lengthened bis(molecular tube) (approximately 200 nm long) through the intermolecular joining of approximately 10 discrete bis(polypseudorotaxane) units and the subsequent removal of the polymer templates. The obtained bis(molecular tube), which is quite soluble in water, dimethylformamide, and dimethyl sulfoxide, has been comprehensively characterized by NMR, gel permeation chromatography, static light scattering, X-ray powder diffraction, thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, and scanning tunneling microscopy. Further investigations demonstrate that this bis(molecular tube) can capture C(60) through interaction with its many pi-electron-rich biquinolino groups.

Inclusion complexes of bisphenol A with cyclomaltoheptaose (beta-cyclodextrin): solubilization and structure.

The inclusion complexation behavior and the solubilization effects of Bisphenol A (BPA, an endocrine-disrupting chemical) by cyclomaltohexaose, -heptaose, and -octaose (alpha-, beta-, and gamma-cyclodextrins) were investigated by (1)H NMR spectroscopy and by elemental analysis. The results showed that beta- and gamma-cyclodextrins gave the satisfactory solubilization ability to BPA up to 7.2 x 10(3) mg L(-1) and 9.

Syntheses and self-assembly behaviors of the azobenzenyl modified beta-cyclodextrins isomers.

A couple of analogues of azobenzenyl beta-cyclodextrins 1 and 2 with self-locked and self-unlocked conformations have been synthesized via the Huisgen cycloaddition from the same reactants, but in distinct reaction conditions (i.e., the hydrothermal synthesis and the "click" reaction, respectively), their conformations were sufficiently proved by X-ray crystal structural analysis, molecular modeling study, and 2D NMR spectroscopy, and their self-assembly behaviors in aqueous solution were also investigated by NMR spectroscopy.

Spectrophotometric study on the controlling factor of molecular selective binding of dyes by bridged bis(beta-cyclodextrin)s with diselenobis(benzoyl) linkers.

A series of beta-cyclodextrin (beta-CD) dimers with 4,4'-diselenobis(benzoyl) linkers, that is, 6,6'-[4,4'-diselenobis(benzoyloxyl)]-bridged bis(beta-CD) (1a), 6,6'-[4,4'-diselenobis[2-(benzoylamino)ethyleneamino]]-bridged bis(beta-CD) (2a), and 6,6'-[4,4'-diselenobis[2-(benzoylamino)-3,6-diazaoctylamino]]-bridged bis(beta-CD) (3a), were synthesized in moderate yields by the reaction of 4,4'-diselenobis(benzoic acid) with beta-CD or oligo(ethylenediamino)-6-deoxy-beta-CD. Their binding behaviors with some structure-related substrates, such as acridine red (AR), neutral red (NR), rhodamine B (RhB), ammonium 8-anilino-1-naphthalenesulfonate (ANS), and 6-p-toluidino-2-naphthalenesulfonic acid (TNS), were investigated in aqueous phosphate buffer solution (pH 7.20) at 298.