First-Line Aumolertinib in -Mutant Advanced Non-Small Cell Lung Cancer: A Multicenter Real-World Retrospective Study with a Four-Year Follow-Up.

Background: The use of third-generation different tyrosine kinase inhibitors (TKIs) is considered the most effective option for treating advanced non-small cell lung cancer (aNSCLC) with epidermal growth factor receptor (EGFR) mutations. However, there is limited information on the efficacy and safety of aumolertinib in patients remains these cases.

Methods: The clinical records of patients receiving aumolertinib as first-line therapy across four hospitals in the Guangxi Zhuang Autonomous Region from April 2020 to December 2021 were retrospectively analyzed, using progression-free survival (PFS) as the primary endpoint and overall survival (OS) representing the secondary endpoint.

Study on Permeability and Flow Characteristics of Composite Thermosensitive Hydrogel and Its Fire Prevention and Extinguishment Performance.

This study focuses on the issues of poor fluidity, low penetration into residual coal, and suboptimal inhibition of coal spontaneous combustion associated with traditional coal mine gel fire retardants. The permeability and flow characteristics of a sodium alginate-based composite thermosensitive hydrogel, as well as its fire prevention and extinguishment performance, were investigated. The findings suggest that the thermosensitive hydrogel behaves as a pseudoplastic fluid at 40 °C and a yield-pseudoplastic fluid at 65 °C, exhibiting shear-thinning behavior with increasing shear rate.

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis.

Osteoarthritis (OA) is a multifactorial, mechano-inflammatory joint disorder characterized by cartilage degradation, synovial inflammation, and subchondral bone remodeling. Despite its high prevalence and significant impact on quality of life, no disease-modifying treatments have been approved. In many other disease areas, advanced omics technologies are impacting the development of advanced therapies.

STAT1-VAMP8 axis drives nasopharyngeal carcinoma progression via autophagy enhancement.

Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high risk of invasion and metastasis. Elucidating the molecular underpinnings of NPC may uncover new diagnostic and therapeutic targets. Vesicle associated membrane protein 8 (VAMP8) is overexpressed and plays an oncogenic role in various tumors.

Correlation between neurogenic injury and lumbar disc degeneration in tethered cord syndrome: a retrospective MRI study based on somatosensory evoked potentials.

Purpose: This study examines the association between neurogenic injury and lumbar intervertebral disc degeneration (LDD) in tethered cord syndrome (TCS) by comparing lumbar sagittal parameters and disc degeneration between patients with normal and abnormal somatosensory evoked potential (SSEP) findings.

Methods: We retrospectively analyzed clinical data from 43 patients diagnosed with TCS between July 2018 and July 2024. Based on tibial nerve somatosensory evoked potential (SSEP) examination results, patients were categorized into SSEP-normal and SSEP-abnormal groups.

Beyond the Check-Up: How Well-Child Exams, Pediatric Specialists, and Provider Recommendations Can Close HPV Vaccine Gaps for Chinese American Teens.

Purpose This study aimed to identify provider- and practice-level factors influencing human papillomavirus (HPV) vaccine uptake among Chinese American (CA) adolescents. Despite increasing public health efforts, HPV vaccination rates in this population remain suboptimal, and knowledge on the link between provider/practice characteristics and vaccine uptake is limited. Methods We analyzed data from 1,272 CA adolescents (aged 13-17) using the National Immunization Survey-Teen (2015-2019) datasets.

Rational module substitution strategy to enhance ACE-inhibitory peptide activity.

Food-derived angiotensin-converting enzyme (ACE)-inhibitory peptide plays key roles in hypertension prevention, however, their activity is dependent on specific sequence composition. This study aims to enhance peptide activity using a module substitution strategy. Molecular docking and activity assays identified MF as a low- and FP as a high-contribution dipeptide module within MFPWP.

Iodine-Promoted Ring-Opening -Difunctionalization of Cyclopropanols with Enaminones: A Selective Route to 2,4-Diacylpyrroles.

In this work, we report a novel I-mediated ring-opening -difunctionalization of cyclopropyl alcohols with enaminones for the first time. The selective [3 + 2] annulation instead of [3 + 3] annulation under metal-free conditions enables a straightforward and efficient synthesis of structurally important 2,4-diacylpyrroles. Notably, this methodology dispenses with metal catalysts, proceeds under mild reaction conditions, and features not only simple operation but also suitability for gram-scale preparation and late-stage functionalization of complex bioactive molecules.

Integrating Precision Medicine and Digital Health in Personalized Weight Management: The Central Role of Nutrition.

Obesity is a global health challenge marked by substantial inter-individual differences in responses to dietary and lifestyle interventions. Traditional weight loss strategies often overlook critical biological variations in genetics, metabolic profiles, and gut microbiota composition, contributing to poor adherence and variable outcomes. Our primary aim is to identify key biological and behavioral effectors relevant to precision medicine for weight control, with a particular focus on nutrition, while also discussing their current and potential integration into digital health platforms.

Advances in Intestinal-Targeted Release of Phenolic Compounds.

Phenols are natural compounds with considerable bioactivities. However, the low bioavailability and chemical instability of phenols limit their biological functions. This review summarizes recent progress in phenol delivery systems that account for the specific physiological conditions of the gastrointestinal tract.

Functional Analysis of BmHemolin in the Immune Defense of Silkworms.

has been identified as a crucial immune gene in insect immune defense. The silkworm is susceptible to infections by pathogenic microorganisms when reared on artificial diets. In this study, through comparative analysis of the expression patterns of BmHemolin in silkworms fed on mulberry leaves and artificial diets, we found that the expression of BmHemolin was significantly upregulated in silkworms reared on artificial diets, and this upregulation was highly likely induced by pathogenic microorganisms.

Single-Nucleus Transcriptome Sequencing Unravels Physiological Differences in Holstein Cows Under Different Physiological States.

Against the backdrop of the large-scale and intensive development of the livestock industry, enhancing the reproductive efficiency of cattle has become a crucial factor in industrial development. Holstein cows, as the most predominant dairy cattle breed globally, are characterized by high milk yield and excellent milk quality. However, their reproductive efficiency is comprehensively influenced by a variety of complex factors, and improving their reproductive performance faces numerous challenges.

Natural Kelp () Hydrogel with Anisotropic Mechanical Properties, Low Friction and Self-Cleaning for Triboelectric Nanogenerator.

Kelp is a natural hydrogel material, which has been widely used in food industry. However, as a natural material, its properties have not been well explored. In this work, the surface and mechanical properties of kelp were investigated.

Assessing the Impact of Different Mixing Strategies on Genomic Prediction Accuracy for Beef Cattle Breeding Values in Multi-Breed Genomic Prediction.

Although genomic selection can accelerate livestock breeding, its application in many countries is hindered due to the limited size of reference populations. To address this issue, researchers have explored methods of combining multiple breeds to create reference populations, aiming to enhance the accuracy of genomic prediction. The main objective of this study was to evaluate the impact of the construction of mixed reference populations at different genetic distance levels on the accuracy of multi-breed genome prediction in multi-breed beef cattle populations using three evaluation methods: GBLUP, ssGBLUP, and wGBLUP.

Enhanced therapeutic efficacy of cationic liposome-delivered nerve growth factor antisense oligonucleotide for interstitial cystitis/bladder pain syndrome.

The pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS) remains unclear, and there is no definitive treatment for this condition. Studies have shown that antisense oligonucleotide (asODN) targeting nerve growth factor (NGF) can downregulate the level of NGF in the bladder, however, the uptake of NGF asODN by the body is limited. Therefore, this study constructed cationic liposomes (CLs) as a delivery system to carry NGF asODN and evaluated its functional efficacy on the bladder.

Correlation of Morphology and Metabolism of Reproductive Traits in the Genus Around the Qinghai-Tibetan Plateau.

The trade-off between offspring size and number is a crucial concept in life-history theory, offering key insights into animal reproductive strategies. Our study examines the relationship between reproductive characteristics, morphological traits, and metabolism in a total of 290 female lizards across 10 species. Reproductive, morphological, and metabolic traits were compared by analyzing lizard species with viviparous and oviparous reproductive modes.

1T/2H-MoS Nanoclusters as Plasmon-Free Surface-Enhanced Raman Spectroscopy Substrates for Ultrasensitive Detection of Environmental Pollutants.

Surface-enhanced Raman spectroscopy (SERS) holds immense promise for molecular detection, yet the quest for high-performance, plasmon-free substrates remains active. This work pioneers the rational design and engineering of phase-tunable MoS nanoclusters─metallic (1T), semiconductor (2H), and, critically, hybrid metal/semiconductor (1T/2H) phases as a novel class of SERS platforms. We demonstrate this exceptional capability for ultrasensitive detection of environmentally hazardous dyes (e.

An easily machine learning-based tool for preliminary risk assessment of microvascular invasion in hepatocellular carcinoma.

Background: Microvascular invasion (MVI) is a crucial risk factor for postoperative recurrence in patients with hepatocellular carcinoma (HCC). Accurate preoperative assessment of MVI and appropriate resection margins (RM) could reduce recurrence rates of HCC.

Methods: A total of 1651 eligible patients who underwent liver resection between January 1, 2018 and June 30, 2023 were retrospectively collected.

Sacubitril suppresses experimental chronic heart allograft vasculopathy.

Chronic allograft vasculopathy (CAV) limits graft and recipient survival after heart transplantation despite modern immune suppression. We examined the effect of sacubitril, an inhibitor of neprilysin neutral endopeptidase activity, on progression of CAV in HY-antigen mismatched mouse heart transplantation. We found sacubitril treatment of the recipient markedly blunted the progressive occlusion of the coronary arterial lumen versus the vehicle control.

Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection.

The A35 protein, expressed on the enveloped virion of monkeypox (mpox) virus (MPXV), is essential for viral infection and spread within the host, making it an effective antiviral target. In this study, we demonstrated two human anti-A35 monoclonal antibodies (mAbs) displayed potential protection against MPXV in CAST/EiJ mice and rhesus macaques. Using cryo-electron microscopy, we determined two high-resolution structures of the A35 dimer in complex with the fragment of antigen binding of mAb 975 or mAb 981, revealing detailed interactions at the antigen-antibody interfaces.

JA Signaling Inhibitor JAZ Is Involved in Regulation of AM Symbiosis with Cassava, Including Symbiosis Establishment and Cassava Growth.

Mutualism between plants and arbuscular mycorrhizal fungi (AMF) is imperative for sustainable agricultural production. Jasmonic acid (JA) signal transduction has been demonstrated to play an important role in AMF symbiosis with the host. In this study, SC9 cassava was selected as the research object to investigate the effect of the jasmonic acid signaling pathway on symbiosis establishment and cassava growth in AMF and cassava symbiosis.

The relationship between disease activity and quality of life in rheumatoid arthritis patients: a network analysis.

Background: The relationship between disease activity and quality of life (QoL) in rheumatoid arthritis (RA) patients was explored using network analysis. The focus of network analysis has recently shifted from studying individual groups to comparing the network structures of different subgroups. RA patients with depressive symptoms generally have lower QoL scores, so we compared the QoL networks of RA patients with and without depressive symptoms to test for differences.

Targeted neural stem cell-derived extracellular vesicles loaded with Sinomenine alleviate diabetic peripheral neuropathy via WNT5a/TRPV1 pathway modulation.

Background: Diabetic peripheral neuropathy (DPN) is one of the most prevalent and debilitating complications of diabetes, marked by chronic neuroinflammation, immune dysregulation, and progressive neuronal degeneration. Current treatments offer limited efficacy, largely focusing on symptomatic relief rather than addressing the underlying disease mechanisms. There is a critical need for disease-modifying therapies that target the molecular basis of DPN.

LncRNA MIR17HG accelerates the development of atherosclerosis by promoting macrophage pyroptosis through the miR-301a-3p/TXNIP pathway.

Atherosclerosis is a chronic inflammatory disease characterized by lipid accumulation, immune dysregulation, and cell death within the arterial wall. While extensive research has been devoted to the understanding of its molecular pathogenesis, novel regulatory factors contributing to its progression remain to be identified. Macrophage pyroptosis and the subsequent inflammatory response play a central role in atherogenesis.