Conjugated D-A Polymers to Integrate the Through-Bond and Through-Space Charge Transfers to Boost the One-For-All Phototheranostics.

To achieve the efficient cancer therapy, one-for-all phototheranostics are highly important, but their engineering of agents is still challenging. Particularly, the balancing of emission and reactive oxygen species (ROS) generation is urgently needed in NIR-II region. To address this issue, a conjugated D-A polymer of PY2V-BDTF is designed to combine the through-bond/through-space charge transfer (TBCT/TSCT) features in a single molecule by connecting D and A units with the rotatable vinyl linkers.

Bazi Bushen capsule modulates Akkermansia muciniphila and spermidine metabolism to attenuate brain aging in SAMP8 mice.

Ethnopharmacological Relevance: Bazi Bushen Capsule (BZBS), a traditional Chinese medicine formulation composed of multiple bioactive herbal components, has been validated in multicenter randomized double-blind controlled trials for its potent anti-aging properties. Previous studies from our group have demonstrated that BZBS effectively restores gut microbiota homeostasis and attenuates the impairment of intestinal barrier function, thereby ameliorating age-related cognitive decline. However, the specific molecular mechanisms by which BZBS modulates key microbial-metabolite networks to delay brain aging remain poorly understood and warrant further investigation.

Highly Emissive Platinum(II) Metallacage in the Near-Infrared Region for Synergistic Chemo-Photodynamic Therapy.

Highly emissive metallacages that generate reactive oxygen species (ROS) are important to synergistic cancer therapy, but it is still challenging to balance the emission and phototheranostic properties. Herein, a metallacage of DTPABT-Mc is prepared. It is observed that emission in the near-infrared region from 600 to 1000 nm with a high photoluminescence quantum yield value of 7.

Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle.

Background And Aim: Muscular atrophy is one of the most common age-related conditions characterized by the deterioration of skeletal muscle structures and impaired functions. It is associated with cellular senescence and chronic inflammation, which impair the function of muscle stem cells. Bazi Bushen (BZBS) is a patent compound Chinese medicine that has been shown to have anti-aging effects in various animal models.

Adaptive complementary neighboring sub-aperture beamforming for thermoacoustic imaging.

Background: When applied to thermoacoustic imaging (TAI), the delay-and-sum (DAS) algorithm produces strong sidelobes due to its disadvantages of uniform aperture weighting. As a result, the quality of TAI images recovered by DAS is often severely degraded by strong non-coherent clutter, which restricts the development and application of TAI.

Purpose: To address this issue, we propose an adaptive complementary neighboring sub-aperture (NSA) beamforming algorithm for TAI.

RPCA-based thermoacoustic imaging for microwave ablation monitoring.

Microwave ablation (MWA) is a potent cancer treatment tool, but its effectiveness can be hindered by the lack of visual feedback. This paper validates the feasibility of using microwave-induced thermoacoustic imaging (TAI) technique to monitor the MWA process. A feasibility analysis was conducted at the principle level and a high-performance real-time TAI system was introduced.

Gait Parameters can Reflect Cognitive Performance in Older Adults with Cerebral Small Vessel Disease: A Cross-sectional Research.

Background: Cerebral small vessel disease (CSVD) is a common chronic progressive disease. It remains unclear whether high gait variability is a marker of cognitive cortical dysfunction.

Methods: This study included 285 subjects (aged from 60 to 85 years, 60.

One Stone, Two Birds: High-Brightness Aggregation-Induced Emission Photosensitizers for Super-Resolution Imaging and Photodynamic Therapy.

Most aggregation-induced emission (AIE) luminogens exhibit high brightness, excellent photostability, and good biocompatibility, but these AIE-active agents, which kill two birds with one stone to result in applications in both stimulated emission depletion (STED) super-resolution imaging and photodynamic therapy (PDT), have not been reported yet but are urgently needed. To meet the requirements of STED nanoscopy and PDT, D-A-π-A-D type DTPABT-HP is designed by tuning conjugated π spacers. It exhibits red-shifted emission, high PLQY of 32.

Recent advances of organic emitters in deep-red light-emitting electrochemical cells.

Light-emitting electrochemical cells (LECs) are kind of easily fabricated and low-cost light-emitting devices that can efficiently convert electric power to light energy. Compared with blue and green LECs, the performance of deep-red LECs is limited by the high non-radiative rate of emitters in long-wavelength region. While various organic emitters with deep-red emission have been developed to construct high-performance LECs, including polymers, metal complexes, and organic luminous molecules (OLMs), but this is seldom summarized.

Aggregation-induced emission (AIE)-active metallacycles with near-infrared emission for photodynamic therapy.

Multifunctional metallacycles with solid-state emission are highly important in cancer therapy. Here, an aggregation-induced emission (AIE)-active metallacycle of DTPABT-MC-R is developed with efficient emission in the NIR region in the solid state (PLQYs = 4.92%).

Reducing Acoustic Inhomogeneity Based on Speed of Sound Autofocus in Microwave Induced Thermoacoustic Tomography.

Microwave induced thermoacoustic tomography is a newly developing non-invasive and non-ionizing modality. In practical applications, such as breast tumor detection and brain imaging, the acoustic properties in the tissue to be detected are usually unknown and spatially non-uniform, which results in distortion and blurring of the buried targets. In this paper, a reconstruction method based on speed of sound (SoS) autofocus is proposed to reduce the effect of acoustic inhomogeneity in different soft tissues.

LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells.

Background: LINE-1 ORF-1p is encoded by the human pro-oncogene . Our previous work showed that LINE-1 ORF-1p could enhance the resistance of hepatocellular carcinoma (HCC) cells to antitumor agents. However, the mechanisms involved in LINE-1 ORF-1p-mediated drug resistance remain largely unknown.

Reducing the effects of acoustic heterogeneity with an iterative reconstruction method from experimental data in microwave induced thermoacoustic tomography.

Purpose: An iterative reconstruction method has been previously reported by the authors of this paper. However, the iterative reconstruction method was demonstrated by solely using the numerical simulations. It is essential to apply the iterative reconstruction method to practice conditions.

Laplacian normalization and random walk on heterogeneous networks for disease-gene prioritization.

Random walk on heterogeneous networks is a recently emerging approach to effective disease gene prioritization. Laplacian normalization is a technique capable of normalizing the weight of edges in a network. We use this technique to normalize the gene matrix and the phenotype matrix before the construction of the heterogeneous network, and also use this idea to define the transition matrices of the heterogeneous network.

Evaluation of contrast enhancement by carbon nanotubes for microwave-induced thermoacoustic tomography.

Microwave-induced thermoacoustic tomography (MITAT) is a hybrid method which constructs images with ultrasound spatial resolution while exploiting dielectric contrast at microwave frequency. It has great potential in biomedical imaging especially in early breast cancer detection. The detection of early stage breast tumor in MITAT is challenged by the moderate endogenous dielectric contrast between malignant and healthy glandular tissues.

Active adjoint modeling method in microwave induced thermoacoustic tomography for breast tumor.

To improve the model-based inversion performance of microwave induced thermoacoustic tomography for breast tumor imaging, an active adjoint modeling (AAM) method is proposed. It aims to provide a more realistic breast acoustic model used for tumor inversion as the background by actively measuring and reconstructing the structural heterogeneity of human breast environment. It utilizes the reciprocity of acoustic sensors, and adapts the adjoint tomography method from seismic exploration.

A prototype system of microwave induced thermo-acoustic tomography for breast tumor.

Microwave-induced thermo-acoustic tomography (MITAT) is an innovative technique for tumor's detection. Due to there has high contrast in terms with permittivity and electrical conductivity of tumor versus normal tissue, even if the tumor still in the early phase it can be imaged clearly. For the proposed MITAT system, low energy microwave pulses are used as the irradiating signals, while the received signals are ultrasound, high contrast and high resolution images can be obtained.

Microwave-induced thermal acoustic tomography for breast tumor based on compressive sensing.

Microwave-induced thermal acoustic tomography (MITAT) is an innovative technique to image biomedical tissues based on their electric properties. It has the advantages of both high contrast and high spatial resolution. Image reconstruction method in MITAT is always a critical issue.