Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction.

Background And Aims: An overactive inflammatory response and immune cell infiltration following myocardial infarction (MI) impair cardiac tissue repair. This study investigates the mechanistic role of the arachidonic acid (AA) metabolic cascade in mediating post-MI inflammation.

Methods: Single-cell RNA-sequencing analysis was performed to characterize cardiac macrophage heterogeneity in post-MI mice.

Dialysis-assisted control significantly enables stable long-term unaerated partial nitrification in a microalgal-bacterial consortium treating hydrolyzed urine.

Source-separated hydrolyzed urine (SSHU), with high ammonium (NH-N) concentration and low carbon-to-nitrogen ratio, presents a critical challenge for conventional biological treatment. This study developed an unaerated microalgal-bacterial consortium (MBC) integrating dialysis to achieve stable partial nitrification (PN) for SSHU treating. This system achieved 166-day stable PN (nitrite accumulation rate >85 %) through three mechanisms: (1) Dialysis and shorten hydraulic retention time (6 d to 2 d) maintained free ammonia (>2.

Structure-based rational design of TLR7/8 antagonists through agonist scaffold reengineering for psoriasis therapy.

Toll-like receptors 7 and 8 (TLR7/8) play pivotal roles in modulating the body's immune response, and their antagonists provide promising treatment options for autoimmune diseases. Here, by modifying the structure of TLR7 agonist SMU-L11, we developed a series of TLR7/8-specific antagonists with therapeutic potential for psoriasis. Experimental validation revealed that structural restriction of the N1 substituent was critical for the pharmacological efficacy of the inverted parent scaffold.

Design, synthesis, and biological evaluation of novel pyrimidine/pyridine derivatives for Vesicular Stomatitis Virus (VSV) infection.

Restricting the transmission of Vesicular Stomatitis Virus (VSV) holds significant economic implications for the livestock industry. Few regulators targeting VSV and rising drug resistance highlight the urgent need for develop new and efficient anti-VSV agents to improve animal welfare. In this study, we employed recombinant VSV expressing green fluorescent protein (VSV-GFP) to evaluate 1,500 compounds from commercial and self-built compound libraries, leading to the identification of SMU-T2d as a lead compound with preliminary anti-VSV activity.

Unraveling plating/stripping-induced strain evolution embedded sensors for predictive failure mitigation in solid-state Li metal batteries.

Solid-state lithium metal batteries represent a critical frontier in energy storage technology, yet persistent interfacial instability between the Li metal anode and solid electrolytes generates detrimental electrochemical-mechanical interactions that undermine the cycling durability. To resolve this fundamental challenge, herein, we establish an innovative real-time strain monitoring that directly correlates micro-mechanical evolution with interfacial degradation during Li plating/stripping. It reveals that Li plating induces significant microstrain accumulation, while stripping processes only partially release mechanical stress.

HDAC6/Trim21 aggravates macrophage inflammatory response and titanium-induced osteolysis via GSDMD signaling pathway.

Total joint arthroplasty is the optimal method for end-stage osteoarticular diseases, but aseptic loosening reduces long-term success. Our prior research demonstrated that wear particles released from loosened prostheses activate macrophages to secrete proinflammatory cytokines, thereby promoting osteoclast formation and osteolysis. Gasdermin D (GSDMD), a key regulator of pyroptosis, is a core step in the production of inflammatory factors after stimulation of macrophage pattern recognition receptors together with downstream inflammatory pathways, and histone deacetylase 6 (HDAC6)/tripartite motif-containing protein 21 (Trim21) is important in regulating activation.

An efficient brain delivery system co-loaded with multiple components of for synergistic treatment of ischemic stroke.

Ischemic stroke is a neurological disease characterized by high morbidity and mortality. A key pathological mechanism involves rapid restoration of blood oxygen in the infarcted area, which triggers oxidative stress and inflammatory responses leading to neuronal damage. The complex etiology of the disease poses challenges to single-target pharmacotherapy, necessitating the development of multi-targeted combination drug treatments.

Biological activity analysis of baicalin nanodrugs: Nanosizing enhances antiviral and anti-inflammatory effects in the treatment of viral pneumonia.

Respiratory syncytial virus (RSV) is a ubiquitous respiratory virus that affects individuals of all ages; however, there is a notable lack of targeted treatments. RSV infection is associated with a range of respiratory symptoms, including bronchiolitis and pneumonia. Baicalin (BA) exhibits significant therapeutic effects against RSV infection through mechanisms of viral inhibition and anti-inflammatory action.

Global Burden of Heart Failure in Adults Aged 20-49 Years, 1990-2021.

Background: Heart failure (HF) among young adults is a growing health concern, yet its global burden remains poorly understood.

Objectives: This study aimed to analyze the prevalence, years lived with disability (YLD), and causes of HF in adults aged 20-49 years from 1990 to 2021, and to project trends through 2035.

Methods: Using data from the Global Burden of Disease Study 2021, we analyzed age-standardized HF prevalence and YLD rates across 204 regions.

Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'-(thiophen-2-yl)thiourea analogs for potential cancer immunotherapy.

TLR2 agonists represent promising cancer immunotherapeutic due to their unique combination of potency and safety. SMU-C68, a human TLR1/2 specific small molecule agonist was identified, exhibiting a remarkable four-fold increase in biological activity compared to previously reported SMU-C80 with enhanced aqueous solubility. The cellular and protein level results confirmed that SMU-C68 facilitated the dimerization of TLR1 and TLR2 proteins, leading to the specific activation of TLR1/2 heterodimers.

ALSP+: Fast Scene Recovery via Ambient Light Similarity Prior.

The absorption and scattering of light in different turbid media cause images to suffer from poor visibility and contrast, which severely affects the performance of many computer vision tasks. To address this issue, we propose a fast scene recovery method based on the Ambient light similarity prior (ALSP). In this method, the ambient light similarity metric is designed from both magnitude and orientation, which is embedded into the optical imaging model, and the estimation of scene transmission is derived by simplification and approximation.

ACPA-Induced ATP release and K efflux trigger NLRP3 inflammasome activation in rheumatoid arthritis.

Objectives: Anti-citrullinated protein antibodies (ACPA) is one of the key inducers of the initiation and maintenance of the immune-inflammatory response in Rheumatoid arthritis (RA), yet evidence is lacking on how ACPA drives the inflammatory response.

Methods: Citrullinated collagen-induced arthritis (C-CIA) were performed to evaluate the inflammatory response, especially NLRP3 inflammasome activation, in ACPA + arthritis model. Macrophages differentiated from THP-1 cell line were stimulated by ACPA purified from RA patients' serum, and the localization and interaction of molecules involved in NLRP3 inflammasome were analyzed by confocal microscopy and immunoprecipitation.

[Initial exploration of non-invasive diagnosis of eosinophilic chronic rhinosinusitis with nasal polyps via nasal brush sampling].

To identify the key epithelial cell characteristics that can accurately diagnose eosinophilic chronic sinusitis with nasal polyps（ECRSwNP） through nasal brush sampling and comparing with the pathological results of nasal polyp tissue sections. Ninety-one patients underwent surgery in the Ophthalmology and ENT Department of the Second People's Hospital of Longgang District, Shenzhen, from January 2022 to July 2024 were selected. The cohort comprised 58 males and 33 females（mean age: 41.

Near-infrared light-triggered methylene blue/berberine co-loaded polydopamine nanoparticles modified with sialic acid for Alzheimer's disease therapy.

Due to the existence of the blood-brain barrier (BBB) and the complicated pathological mechanisms of Alzheimer's disease (AD), current therapeutic approaches for AD show limited efficacy. To overcome these challenges, a multi-strategy drug delivery system (SA-BP-MB/BBR NPs) was developed: photothermal conversion polydopamine nanoparticles (PDA NPs) were decorated with sialic acid-modified bovine serum albumin (SA-BSA) to prepare SA-modified and BSA-stabilized PDA NPs (SA-BP NPs) for targeting the BBB and co-loaded with photosensitizer methylene blue (MB) and berberine (BBR) to target multiple neuropathological factors, including Aβ aggregation and tau hyperphosphorylation. The prepared SA-BP-MB/BBR NPs had spherical morphology with a uniform particle size of 143.

Isolated Copper Atoms Boost *NO Adsorption and Active Hydrogen Retention over Zinc Oxide for Ammonia Electrosynthesis at Ampere-Level Current Densities.

The use of renewable electricity to drive the electroreduction of nitrate to ammonia can simultaneously achieve the green synthesis of ammonia and alleviate the environmental pollution of nitrate. However, the industrial requirement for ammonia synthesis with ampere-level current densities remains a grand challenge. In addition, the electroreduction of nitrate to ammonia reaction requires multiple steps of deoxygenation and hydrogenation of *NO intermediates.

Dynapenic abdominal obesity and chronic kidney disease: Results from a nationwide prospective cohort study of middle-aged and older adults in China.

Introduction: The relationship between dynapenic abdominal obesity (D/AO) and chronic kidney disease (CKD) remains underexplored, particularly among Chinese middle-aged and older adults. This study aimed to address this gap by examining the association between these conditions in a specific population.

Method: We conducted a prospective analysis utilizing two waves (2011 and 2015) of data from 5932 participants aged ≥45 years in the China Health and Retirement Longitudinal Study (CHARLS).

Mechanical mechanics-reclaiming a new battlefield for chronic liver disease.

Background: In the 21st century, significant breakthroughs have been made in the research of chronic liver disease. New biochemical markers of pathogenicity and corresponding drugs continue to emerge. However, current treatment strategies remain unsatisfactory due to complex pathological changes in the liver, including vascular dysfunction, myofibroblast-like transition, and local tissue necrosis in liver sinusoids.

Design, synthesis and biological evaluation of dapsone derivatives with broad-spectrum antiviral activity.

Inhibition of STAT2 degradation has emerged as a promising strategy for flaviviruses. The NS5 protein of the ZIKV and DENV-2 inhibits the IFN-Ⅰ antiviral response by degrading STAT2, thereby evading the host's immune defense. Therefore, the development of novel agents capable of inhibiting STAT2 degradation via targeted modulation constitutes a pivotal therapeutic strategy for controlling viral infections.

FPGA-Based Particle Swarm Collaborative Target Localization Algorithm for UAV Swarms.

To achieve precise collaborative localization of multiple unmanned aerial vehicles (UAVs) in hardware environments, this paper presents an field-programmable gate array-based particle swarm optimization (PSO) algorithm aimed at enhancing the localization efficiency of multiple nodes targeting a specific object. By leveraging the unique computational capabilities of FPGA, the proposed algorithm integrates optimization strategies, including particle mutation, variable crossover probabilities, and adjustable weights. These strategies collectively enhance the performance of the PSO algorithm in localization tasks.

Antimicrobial properties and preservation potential of Allium sativum L-derived extracellular vesicle-like particles for food applications.

This study proposes an innovative approach to food preservation by leveraging extracellular vesicle-like particles derived from Garlic (ASL-EVLPs) as a natural and effective preservation agent. To address the limitations of chemical preservatives and sensory drawbacks of garlic, we systematically investigated the antibacterial mechanisms, stability, and sensory impact of ASL-EVLPs. The isolated ASL-EVLPs exhibited notable stability and biocompatibility.

Turning the Selectivity of CO Electroreduction from Acetate to Ethanol by Alloying FCC-Phased Cu with Atomically Dispersed Mn Atoms.

The predominant product of CO electroreduction (COER) is often acetate, with the Faradaic efficiency (FE) for ethanol usually falling below 50%. Herein, we propose a unique strategy to enhance product selectivity in COER, shifting it from acetate predominance toward ethanol generation via alloying atomic manganese (Mn) atoms with a face-centered cubic (FCC) copper (Cu) catalyst. By optimizing the atomic ratio of Mn to Cu, we observe an impressive enhancement of 8.

Development and operation of indigenous microalgal-bacterial consortium system treating eutrophic lake water: Consortium identification and system demonstration.

Natural water bodies such as the inland lake suffers from eutrophication due to excessive nutrient, particularly nitrogen and phosphorus. This study demonstrated an indigenous microalgal-bacterial consortium (IMBC) system to treat eutrophic lake. Three IMBC were enriched from eutrophic lake water or/and sediments, exhibiting superior growth and complete nutrient removals compared to two commercial microalgal species.

[A case of coronary artery protection in transcatheter aortic valve replacement of quadricuspid aortic valve].

A 72-year-old patient with quadricuspid aortic valve underwent transcatheter aortic valve replacement due to severe valve stenosis accompanied by moderate insufficiency. As initially planned, the right coronary artery was protected during the procedure. However, after the artificial valve was released, the left coronary artery was found to be blocked, so a coronary protection stent was implanted in the left coronary artery ostium under the guidance of intravascular ultrasonography.

Physiological and genetic responses of Chlorella sp. to nitrite accumulation in microalgal-bacterial consortium with partial nitrification treating municipal wastewater.

The integration of microalgal-bacterial consortium (MBC) with partial nitrification (PN-MBC) offers a promising strategy for low-carbon wastewater treatment. However, the gradually accumulated nitrite levels challenge microalgal activities and system stability. This study demonstrated the nitrite tolerance (10-300 mg/L) of Chlorella sp.