Enhancing deflection efficiency of resonant cavity light-emitting diodes integrating with metagrating via the internal absorption effect.

Controlling the light-emitting direction is crucial for the application of micro light-emitting diodes in the display field. Resonant cavity light-emitting diodes (RCLEDs) integrating with metagrating can achieve efficient deflection functionality. In this work, we systematically investigate the impact of the number of TiO/SiO pairs in the upper distributed Bragg reflectors (DBR) and spacing between the RCLED and metagrating on deflection efficiency using a three-dimensional finite-difference time-domain (3D FDTD) method.

MIP/WS-AC@Cu-MOF(199)/GCE composite: A robust solution for rapid and selective on-site electrochemical detection of perfluorooctane in real samples.

Perfluorinated compounds (PFCs), recognized as emerging environmental pollutants of global concern due to their persistence and bioaccumulation, have posed serious threats to human health. This underscores the critical need for developing rapid and accurate detection methods for PFCs. In this study, we proposed a novel electrochemical detection approach for perfluorooctanoic (PFO), a representative PFC, employing a WS-AC-modified Cu-MOF(199) electrode integrated with molecularly imprinted polymer (MIP) technology.

Post-removal for the deposited Au metal to increase the light extraction efficiency for AlGaN-based deep-ultraviolet light-emitting diodes.

Ni/Au is employed to ensure a high-quality p-type ohmic contact for most AlGaN-based deep-ultraviolet light-emitting diodes (DUV LEDs). However, the substantial absorptivity of ultraviolet light by Ni/Au significantly impacts the light extraction efficiency (LEE). In this work, to reduce the absorptivity of a Ni/Au electrode, we conduct wet-etching to the Ni/Au electrode after the formation of ohmic contact between Ni/Au and p-AlGaN.

Enhanced light extraction efficiency for the inclined-sidewall-shaped AlGaN-based DUV LED by using an omni-directional reflector with a thin hybrid dielectric layer.

In this Letter, an omni-directional reflector (ODR) with a thin hybrid dielectric layer (hybrid-ODR) is proposed to enhance the light extraction efficiency (LEE) for inclined-sidewall-shaped AlGaN-based deep ultraviolet light-emitting diode (DUV LED) by inserting a thin diamond with high refraction index into a conventional Al/AlO-based ODR. The three-dimensional finite-difference time-domain (3D FDTD) simulation results show that the LEE of TM-polarized light for the DUV LED with hybrid-ODR is enhanced by 18.5% compared with Al/AlO-based ODR.

Enhancing light extraction efficiency of the inclined-sidewall-shaped DUV micro-LED array by hybridizing a nanopatterned sapphire substrate and an air-cavity reflector.

In this work, we hybridize an air cavity reflector and a nanopatterned sapphire substrate (NPSS) for making an inclined-sidewall-shaped deep ultraviolet micro light-emitting diode (DUV micro-LED) array to enhance the light extraction efficiency (LEE). A cost-effective hybrid photolithography process involving positive and negative photoresist (PR) is explored to fabricate air-cavity reflectors. The experimental results demonstrate a 9.

On the origin of the enhanced light extraction efficiency of DUV LED by using inclined sidewalls.

It is known that light extraction efficiency (LEE) for AlGaN-based deep ultraviolet (DUV) light-emitting diodes (LEDs) can be enhanced by using an inclined sidewall of mesa. However, the reported optimal inclined angles are different. In this work, to explore the origin for enhancing the LEE of DUV LED by using inclined sidewalls, we investigate the effect of an inclined sidewall angle on the LEE for AlGaN-based DUV LEDs with different mesa diameters by using ray tracing.

Continuous ultrasonic ozone coupling technology-assisted control of ceramic membrane fouling coupled enhanced multiphase mixing to treat dye wastewater and CFD flow field simulation.

In this study, ozone catalysts (hydrogenation-modified red mud, HM-RM) successfully prepared by hydrogenation-modification of industrial hazardous solid waste red mud (RM) as a raw material in accordance with the viewpoint of treating waste with waste and using waste. Meanwhile, as for the common phenomenon of membrane fouling, uneven distribution of multiphase solid catalysts and ozone in liquids, the addition of ultrasound can not only disperse materials, but also play a role in online cleaning of ceramic membranes and catalysts. The optimum treatment conditions for Rhodamine B (RhB) solution with volume of 2 L and concentration of 40 mg/L were catalyst concentration of 0.

Simultaneous removing algal and its extracellular organic matters by Mg/Al-layered double hydroxide /La-montmorillonite.

Rapid and effective simultaneous removal of algal and extracellular organic matter (EOM) is essential for algal blooms water emergency treatment. In this study, a composite material was prepared by physical and chemical interaction between La-montmorillonite (La-MMT) and Mg/Al-layered double hydroxide (LDHs), and its removal effect of algal and extracellular organic matters (EOM) was investigated. The results showed that the removal rate of chlorophyll a () was 96.

Research progress of lens zonules.

Background: The lens zonule, a circumferential system of fibres connecting the ciliary body to the lens, is responsible for centration of the lens. The structural, functional, and positional abnormalities of the zonular apparatus can lead to the abnormality of the intraocular structure, presenting a significant challenge to cataract surgery.

Main Text: The lens zonule is the elaborate system of extracellular fibers, which not only centers the lens in the eye but also plays an important role in accommodation and lens immunity, maintains the shape of the lens, and corrects spherical aberration.

Bioimaging and detecting endogenous and exogenous cyanide in foods, living cells and mice based on a turn-on mitochondria-targeted fluorescent probe.

A novel fluorescent probe, with advanced features including "turn-on" fluorescence response, high sensitivity, good compatibility, and mitochondria-targeting function, has been synthesized based on structural design for detecting and visualizing cyanide in foods and biological systems. An electron-donating triphenylamine group (TPA) was employed as the fluorescent and an electron-accepting 4-methyl-N-methyl-pyridinium iodide (Py) moiety was used as a mitochondria-targeted localization unit, which formed intramolecular charge transfer (ICT) system. The "turn-on" fluorescence response of the probe (TPA-BTD-Py, TBP) toward cyanide is attributed two reasons, one is the insertion of an electron-deficient benzothiadiazole (BTD) group into the conjugated system between TPA and Py, and the other is the inhibition of ICT induced by the nucleophilic addition of CN.

Low-dose topiramate and hydrochlorothiazide-associated early acute myopia and angle narrowing: A case report.

Purpose: To report a unique case of topiramate and hydrochlorothiazide associated with acute myopia and angle narrowing.

Patients And Methods: A 34-year-old Asian woman presented with prominent binocular visual acuity decrease 6 h after taking only one dose of 25 mg topiramate, 25 mg hydrochlorothiazide, and 22.4 mg fluoxetine to lose weight.

Intermolecular and Intramolecular Priming Co-directed Synergistic Multi-strand Displacement Amplification Empowers Ultrasensitive Determination of microRNAs.

The construction of isothermal nucleic acid amplification systems with extremely high signal amplification abilities is of great importance for biomarker detection and disease diagnosis. Herein, for the first time, we proposed an intermolecular and intramolecular priming co-directed synergistic multi-strand displacement amplification (SM-SDA) system for microRNA (miRNA) detection. Strategically, the SM-SDA system is made of a single multi-functionalized hairpin probe (MF-HP) that is engineered with a long stem and endowed with target complementation, configuration transformation, enzyme recognition, and signal reporting abilities.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

Inspired by our previous efforts on the modifications of diarylpyrimidines as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTI) and reported crystallography study, novel diarylnicotinamide derivatives were designed with a "triazole tail" occupying the entrance channel in the NNRTI binding pocket of the reverse transcriptase to afford additional interactions. The newly designed compounds were then synthesized and evaluated for their anti-HIV activities in MT-4 cells. All the compounds showed excellent to good activity against wild-type HIV-1 strain with EC of 0.

Ginsenoside-Rb1-Mediated Anti-angiogenesis via Regulating PEDF and miR-33a through the Activation of PPAR-γ Pathway.

Angiogenesis is the formation of new blood vessels from the existing vasculature, which is involved in multiple biological processes, including atherosclerosis, ischemic heart disease, and cancer. Ginsenoside-Rb1 (Rb1), the most abundant ginsenoside isolated form Panax ginseng, has been identified as a promising anti-angiogenic agent via the up-regulation of PEDF. However, the underlying molecular mechanisms still unknown.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.

As a continuation of our efforts to discover and develop "me-better" drugs of DAPYs, novel diarylpyridine derivatives were designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells. The majority of these compounds showed high activity against wild-type HIV-1 strain (IIIB) with EC values in the range of 0.04-4.

PEDF improves atherosclerotic plaque stability by inhibiting macrophage inflammation response.

Background: Atherosclerosis is a vascular disease with plaque formation and growth. Instable plaque with chronic inflammation is closely related to adverse cardiac outcomes. Pigment epithelium-derived factor (PEDF) is an endogenous multifunctional cytokine that possesses the ability of anti-inflammation.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives targeting the entrance channel of NNRTI binding pocket.

The development of novel NNRTIs with activity against variants of HIV-1RT is crucial for overcoming treatment failure. In the present study, a series of novel 6-substituted diarylpyridine derivatives targeting the entrance channel of the NNIBP of RT were designed through a molecular hybridization strategy. Encouragingly, these new diarylpyridine derivatives were found to be active against wild-type (WT) HIV-1 with an EC50 values ranging from 0.

Design, synthesis and anti-HIV evaluation of novel diarylnicotinamide derivatives (DANAs) targeting the entrance channel of the NNRTI binding pocket through structure-guided molecular hybridization.

Through a structure-based molecular hybridization approach, a novel series of diarylnicotinamide derivatives (DANAs) targeting the entrance channel of HIV-1 NNRTIs binding pocket (NNIBP) were rationally designed, synthesized and evaluated for their anti-HIV activities in MT-4 cells together with the inhibition against the reverse transcriptase (RT) in an enzymatic assay. Encouragingly, most of the new DANAs were found to be active against wild-type HIV-1 with an EC50 in the range of 0.027-4.

Ginsenoside-Rg1 enhances angiogenesis and ameliorates ventricular remodeling in a rat model of myocardial infarction.

Ginsenoside-Rg1 (Rg1) has been used in the traditional Chinese medicine for over 2,000 years. The present study was performed to test our hypothesis that Rg1 provides pro-angiogenic and anti-fibrotic benefits in the ischemic myocardium in a rat model of myocardial infarction. The expression of vascular endothelial growth factor (VEGF) and phosphorylation/activation of PI3K, Akt, and p38 MAPK signaling pathways were examined in human umbilical vein endothelial cells and in the myocardial samples of rats.

Seven-year follow-up of LASIK for moderate to severe myopia.

Purpose: To evaluate long-term refractive outcomes of LASIK for correcting moderate to severe myopia.

Methods: A long-term (7-year) prospective follow-up study of visual and refractive outcomes in patients who underwent myopic LASIK surgery in 1998 and 1999. Fifty-nine patients (104 eyes) of the original cohort of 75 patients underwent detailed clinical assessment at 1 and 7 years postoperatively.

Long-term prospective follow-up study of myopic photorefractive keratectomy.

The aim of this study was to evaluate the long-term outcome of excimer laser myopic photorefractive keratectomy (PRK). We undertook an 11-year prospective follow-up study of visual and refractive outcomes in 46 patients (85 eyes). The main outcome measures were predictability, efficacy, stability and safety of PRK.