Mechanisms of food-derived active peptides ameliorating or preventing hyperlipidemia and bioinformatics analysis of molecular targets.

is a prevalent metabolic disorder that can lead to other illnesses. Natural products in food, such as active peptides, can help alleviate . This study seeks to elucidate the mechanism through which food-derived active peptides (FDAPs) mitigate .

Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review.

As a prevalent metabolic disorder, the increasing incidence of diabetes imposes a significant burden on global healthcare. Flavonoids in natural phytochemical products exhibit notable hypoglycemic properties, making them potential alternatives for diabetes treatment. This article summarizes the hypoglycemic properties of flavonoid subcategories studied in recent years, including flavones, isoflavones, flavonols, flavanols, and others.

Phenylpropanoids for the control of fungal diseases of postharvest fruit.

In recent years, there has been a growing interest in developing greener and safer substances for the control of postharvest fungal diseases of fruit. Secondary metabolic pathways play an important role in plant defense responses, and the phenylpropanoid metabolic pathway is one of the most important secondary metabolic pathways in plant defense. More and more studies have shown that exogenous phenylpropanoids treatments can inhibit postharvest fungal diseases.

Recent advances in the effect of simulated gastrointestinal digestion and encapsulation on peptide bioactivity and stability.

Food-derived bioactive peptides have garnered significant attention from researchers due to their specific biological functions, including antihypertensive, antioxidant, antidiabetic, anticancer, anti-inflammatory, and anti-osteoporosis properties. Despite extensive research, the bioactivity of these peptides may be compromised in the gastrointestinal tract due to enzymatic hydrolysis before reaching the bloodstream or target cells. Therefore, understanding the fate of bioactive peptides during digestion is crucial before advancing to clinical trials and commercial applications.

Combined analysis of transcriptomics and metabolomics showed that SNAC4 and SNAC9 are negative regulators of the resistance to Botrytis cinerea in tomato.

NAC (NAM, ATAF1/2 and CUC2) is a transcription factor which contributes to the response for both biotic and abiotic stresses. In this study, the regulatory effects and potential mechanisms of SNAC4/9 on resistance to Botrytis cinerea (B. cinerea) were investigated by the differences in physiological and biochemical indices as well as transcriptional and metabolic profiles between SNAC4/9 overexpressed (OE-SNAC4/9) and wild-type (WT) tomato fruit inoculated with B.

Bioactive compounds regulate appetite through the melanocortin system: a review.

Obesity, a significant health crisis, arises from an imbalance between energy intake and expenditure. Enhancing appetite regulation has garnered substantial attention from researchers as a novel and effective strategy for weight management. The melanocortin system, situated in the hypothalamus, is recognized as a critical node in the regulation of appetite.

The Recent Progress of Tricyclic Aromadendrene-Type Sesquiterpenoids: Biological Activities and Biosynthesis.

The tricyclic-aromadendrene-type sesquiterpenes are widely distributed and exhibit a range of biological activities, including anti-inflammatory, analgesic, antioxidant, antibacterial, insecticidal and cytotoxic properties. Several key sesquiterpene synthases (STSs) of this type have been identified, of which, viridiflorol synthase has been engineered for efficiently biosynthesizing viridiflorol in an strain. This paper comprehensively summarizes the distribution and biological activity of aromadendrene-type sesquiterpenes in plant essential oils and microorganisms.

Chitosan-ginger essential oil nanoemulsions loaded gelatin films: A biodegradable material for food preservation.

The alarming issue of food waste, coupled with the potential risks posed by petroleum-based plastic preservation materials to both the environment and human health necessitate innovative solutions. In this study, we prepared nanoemulsions (NEs) of chitosan (CS) and ginger essential oil (GEO) and systematically evaluated the effects of varying NEs concentrations (0, 10 %, 30 %, 50 %) on the physicochemical properties and biological activities of gelatin films. These films were subsequently applied to blueberry preservation.

Scoparone from Thunb. induces apoptosis in HepG2 cells via activation of both intracellular and extracellular pathways.

Six separated compounds were identified from Thunb., and they were 7-methoxycoumarin (1), 6,7-dimethoxycoumarin (2), 7-hydroxy-6-methoxycoumarin (3), quercetin (4), chlorogenic acid (5) and caffeic acid (6). Among them, 6,7-dimethoxycoumarin, as known as scoparone, was the most effective on scavenging ABTS free radicals (IC = 0.

CRISPR/Cas9-mediated SNAC9 mutants reveal the positive regulation of tomato ripening by SNAC9 and the mechanism of carotenoid metabolism regulation.

NAC transcriptional regulators are crucial for tomato ripening. Virus-induced gene silencing (VIGS) of (, Gene ID: 101248665) affects tomato ripening, and is involved in ethylene and abscisic acid (ABA) metabolic pathways. However, the function of in pigment metabolism in tomatoes remains unclear.

The characterization of antimicrobial nanocomposites based on chitosan, cinnamon essential oil, and TiO for fruits preservation.

The freshness and safety of fruits have always been crucial issues in the development of the industry. However, the existing fresh-keeping methods have limited effect, meanwhile, the preservation mechanism of different materials. In this study, Cinnamon essential oil (CEO), TiO and chitosan (CS) were compounded to prepare safe and renewable nanocomposites (CS-T-C) for fruit preservation.

Glycine betaine inhibits postharvest softening and quality decline of winter jujube fruit by regulating energy and antioxidant metabolism.

Winter jujube fruit easily softens after harvest. To investigate the effects of glycine betaine (N,N,N-trimethylglycine; GB) treatment on the quality of postharvest jujubes, fresh winter jujubes (Zizyphus jujuba Mill. cv.

Mechanisms of Biochanin A Alleviating PM2.5 Organic Extracts-Induced EMT of A549 Cells through the PI3K/Akt Pathway.

Epithelial-mesenchymal transition (EMT) is an important step in tumor progression, which enables tumor cells to acquire migration and invasion characteristics. The aim of this study was to investigate the mechanism of biological biochanin A (BCA) in ameliorating fine particulate matter (PM2.5) lung injury.

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review.

Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients.

Transcriptome analysis reveals the potential mechanism of polyethylene packing delaying lignification of .

Transcriptome analysis is important for the quality improvement of edible fungi, however, the effect of polyethylene (PE) packaging on the preservation of at the transcriptome level still needs to be further investigated. In order to elucidate the effect of PE on delaying lignification of , this study focused on exploring effects of PE on enzymes and genes involved in lignification. The results showed that PE packaging delayed the deterioration of phenotype, color difference and weight loss rate of , inhibited lignin and HO content and maintained firmness and cellulose content.

Glyphosate-induced GhAG2 is involved in resistance to salt stress in cotton.

The transcription of GhAG2 was strongly enhanced by glyphosate treatment. Overexpression of GhAG2 could improve plant tolerance to salt and salicylic acid stress. Although glyphosate has been widely used as an herbicide over the past decade owing to its high efficacy on weed controls and worldwide commercialization of glyphosate-resistant crops, little is known about the glyphosate-induced responses and transcriptional changes in cotton plants.

Propyl Gallate Treatment Improves the Postharvest Quality of Winter Jujube ( Mill. cv. Dongzao) by Regulating Antioxidant Metabolism and Maintaining the Structure of Peel.

The quality and color of winter jujube fruits are easy to change after harvest. We studied the regulation mechanism of propyl gallate (PG) on post-harvest physiological quality of winter jujube, from the perspective of antioxidant metabolism and peel structure. In our research, winter jujube fruits were treated with 0.

Toxicology of respiratory system: Profiling chemicals in PM for molecular targets and adverse outcomes.

Numerous studies have shown that the increasing trend of respiratory diseases have been closely associated with the endogenous toxic chemicals (polycyclic aromatic hydrocarbons, heavy metal ions, etc.) in PM. In the present study, we aim to determine the strong correlations between the chemicals in PM and the adverse consequences.

Nutritional constituent and health benefits of chickpea (Cicer arietinum L.): A review.

Chickpea (Cicer arietinum L.), an annual plant of the Fabaceae family, is mainly grown in temperate and semiarid regions. Its biological activity and beneficial contribution to human health have been scientifically confirmed as an essential source of nutritional components.

Different regulatory mechanisms of plant hormones in the ripening of climacteric and non-climacteric fruits: a review.

This review contains the regulatory mechanisms of plant hormones in the ripening process of climacteric and non-climacteric fruits, interactions between plant hormones and future research directions. The fruit ripening process involves physiological and biochemical changes such as pigment accumulation, softening, aroma and flavor formation. There is a great difference in the ripening process between climacteric fruits and non-climacteric fruits.