Electrosynthesis of Six-Carbon Acetal from CO Using a Tandem Electrolysis.

The conversion of CO into high-value chemicals using renewable electricity offers a promising pathway toward carbon neutrality and sustainable chemical production. However, efficiently transforming CO into molecules with more than three carbon atoms remains a major challenge. Herein, we propose, for the first time, a tandem electrocatalytic strategy for converting CO into the highly valuable six-carbon compound 1,1-diethoxyethane (DEE, valued at ∼$7,000 per ton).

Electrosynthesis of Chemicals from Biomass Glycerol.

The electrosynthesis of chemicals from biomass-derived glycerol presents a promising pathway for sustainable chemical production, effectively addressing surplus glycerol from biodiesel production and using intermittent electrical energy. This process involves electrochemical conversion of glycerol into valuable products, offering an alternative to the traditional thermochemical route. In this Perspective, we first review the state-of-the-art electrochemical conversion of glycerol into various valuable chemicals, such as glyceric acid, lactic acid, glycolaldehyde, and formic acid.

Electrosynthesis of ethylene glycol from biomass glycerol.

Ethylene glycol, a widely used chemical, has a large global capacity exceeding 40 million tons per year. Nevertheless, its production is heavily reliant on fossil fuels, resulting in substantial CO emissions. Herein, we report an approach for electrochemically producing ethylene glycol from biomass glycerol.

Efficacy and safety of tyrosine kinase inhibitors with thoracic radiotherapy for patients with oncogene-mutated non-small cell lung cancer: a meta-analysis.

Background: Tyrosine Kinase Inhibitors (TKIs) is an important therapy for patients with oncogene-mutated Non-Small Cell Lung Cancer (NSCLC). However, acquired resistance remains a major challenge. The efficacy of TKIs plus thoracic radiotherapy (RT) in oncogene-mutated NSCLC patients is uncertain.

Ultrasonic-assisted synthesis of MOF-199 on the surface of carboxylated cellulose fibers for efficient adsorption of methylene blue.

A high-efficiency porous adsorbent, MOF-199/carboxylated cellulose fibers (MOF-199/CCF), was synthesized at room temperature through carboxylation modification, simple sonication, and vacuum drying. The sonication method produced small MOF-199 particles (tens of nanometers), which allowed for uniform distribution of MOF-199 on CCF and improved its efficiency. The presence of CCF carriers reduces the agglomeration of MOF-199 and enhances its performance.

Efficacy and safety of neoadjuvant immunotherapy plus chemotherapy followed by adjuvant immunotherapy in resectable non-small cell lung cancer: a meta-analysis of phase 3 clinical trials.

Objective: At present, several important trials have been published show that perioperative immunotherapy combined with chemotherapy can improve the prognosis of patients with resectable non-small cell lung cancer, which further optimizes treatment options. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of perioperative immunotherapy combined with chemotherapy in resectable non-small cell lung cancer.

Methods: The following databases were searched for relevant studies: PubMed, EMBASE, Cochrane library (updated 12 October 2023).

Efficacy of tyrosine kinase inhibitors in patients with advanced or metastatic sarcomas after prior chemotherapy: A meta-analysis.

Background: Sarcoma is a heterogeneous malignancy arising from interstitial tissue. Anthracycline-based therapy is the first-line treatment recommended by guidelines for patients with locally advanced or metastatic unresectable sarcoma. Recently, targeted therapies, in particular tyrosine kinase inhibitors (TKIs), have made significant progress in the treatment of sarcoma, and their efficacy has been investigated in randomized controlled trials.

Efficacy and safety of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy in locally advanced esophageal cancer: An updated meta-analysis.

Background: Currently, the optimal treatment for neoadjuvant therapy for locally advanced esophageal cancer is not clear, and there is no evidence that neoadjuvant chemoradiotherapy (nCRT) is superior to neoadjuvant chemotherapy (nCT). Due to the publication of new clinical trials and defects in previous meta-analyses, we conducted an updated meta-analysis to evaluate the efficacy and safety of nCRT and nCT.

Methods: The following databases were searched for studies: PubMed, EMBASE, and Cochrane library (updated to April 22, 2023).

Efficacy and safety of once-weekly basal insulin versus once-daily basal insulin in patients with type 2 diabetes: A systematic review and meta-analysis.

Background: Once-weekly insulin is expected to improve treatment compliance and durability and lead to better glycemic control. Several clinical trials on once-weekly insulin have recently been published. We conducted a systematic review and meta-analysis to investigate the efficacy and safety of once-weekly insulin versus once-daily insulin in type 2 diabetes (T2D).

Efficacy and safety of zolbetuximab for first-line treatment of advanced Claudin 18. 2-positive gastric or gastro-esophageal junction adenocarcinoma: a systematic review and meta-analysis of randomized controlled trials.

Objective: Zolbetuximab is a "first-in-class" chimeric lgG1 monoclonal antibody targeting Claudin18.2 (CLDN 18.2).

Efficacy and safety of salvage radiotherapy combined with endocrine therapy in patients with biochemical recurrence after radical prostatectomy: A systematic review and meta-analysis of randomized controlled trials.

Background: The addition of endocrine therapy to salvage radiotherapy (SRT) is expected to further improve the prognosis of patients with biochemical recurrence of prostate cancer after radical prostatectomy (RP). The quantitative synthesis of clinical outcomes of SRT combined with endocrine therapy is limited. Whether salvage radiotherapy plus endocrine therapy remains inconclusive.

Mesoscopic simulations of drug-loaded diselenide crosslinked micelles: Stability, drug loading and release properties.

Intelligent reversible crosslinked micelles that have a good balance of structure stability in normal tissue and controlled drug release responded to the tumor microenvironment are highly promising novel drug delivery systems. However, to date, there have been very few reports about mesoscale simulations of drug-loaded polymeric reversible crosslinked micelles. Here, dissipative particle dynamics (DPD) simulation, the nearest-neighbor bonding principle, and the nearest media-bead bond breaking principle were used to investigate the influence of physiological environment along with low tumor pH and reduction microenvironment on the stability and doxorubicin (DOX) distribution of the star polymer [PCL-b-P(HEMA-Se-Se˜)-b-PPEGMA] diselenide crosslinked micelles with different diselenide crosslinking levels (CLs).

Does macroscopic flow geometry influence wetting dynamic?

The macroscopic flow geometry has long been assumed to have little impact on dynamic wetting behavior of liquids on solid surfaces. This study experimentally studied both spontaneous spreading and forced wetting of several kinds of Newtonian and non-Newtonian fluids to study the effect of the macroscopic flow geometry on dynamic wetting. The relationship between the dynamic contact angle, θ(D), and the velocity of the moving contact line, U, indicates that the macroscopic flow geometry does not influence the advancing dynamic wetting behavior of Newtonian fluids, but does influence the advancing dynamic wetting behavior of non-Newtonian fluids, which had not been discovered before.

Dynamic wetting of non-newtonian fluids: multicomponent molecular-kinetic approach.

Hydrodynamic models are generally applied to describe the dynamic wetting of newtonian or non-newtonian fluids on a solid surface. Conversely, the molecular-kinetic paradigm is only utilized for spreading newtonian fluids while considering the movement of a contact line as a molecular hopping process. This study extended the molecular-kinetic paradigm to the wetting behavior of non-newtonian fluids, while assuming there are n fluid components at the contact line regime interacting simultaneously with a solid surface during front movement.

Spreading of completely wetting, non-Newtonian fluids with non-power-law rheology.

Spreading non-Newtonian liquids with non-power-law rheology on completely wetting surfaces are seldom investigated. This study assessed the wetting behavior of polydimethylsiloxane (PDMS), a Newtonian fluid, two carboxymethylcellulose (CMC) sodium solutions, a PDMS+2%w/w silica nanoparticle suspension and three polyethylene glycol (PEG400)+5-10%w/w silica nanoparticle suspensions (non-power-law fluids) on a mica surface. The theta(D)-U and R-t data for spreading drops of the six tested, non-power-law fluids can be described by power-law wetting models.

Spreading dynamics of power-law fluid droplets.

This paper aims at providing a summary of the theoretical models available for non-Newtonian fluid spreading dynamics. Experimental findings and model predictions for a Newtonian fluid spreading test are briefly reviewed. Then how the complete wetting and partial wetting power-law fluids spread over a solid substrate is examined.