Potential components and action mechanism of Tongzhi Surunjiang Pills against acute gouty arthritis: UPLC-MS/MS, network pharmacology, molecular docking, and transcriptomic analysis.

Ethnopharmacological Relevance: Gouty arthritis (GA) is a disease caused by the malfunction of purine and/or uric acid metabolism. Tongzhi Surunjing Pills (TZSRJP), a traditional Chinese medicine formula derived from the ancient Uyghur book "Karzhibadin Kadeer", is used clinically to treat GA, which still needs more research in its complex regulatory mechanisms.

Aim Of Study: The aim of the study was to elucidate the main potential active components of TZSRJP and the mechanism by which it treated GA.

A Rare Case of Osteomyelitis Caused by Scedosporium Apiospermum in the Right Foot of an Immunocompetent Patient.

Background: Fungal osteomyelitis is rare in clinical practice, and osteomyelitis caused by Scedosporium apiospermum is even rarer, which is easy to misdiagnose, and it is resistant to many antifungal drugs, which makes it tricky to treat. Early diagnosis and accurate treatment are essential.

Case Presentation: A 38-year-old healthy male has been experiencing recurrent pain in his right foot, accompanied by skin ulcers and exudate, for the past five years.

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Nano-titanium dioxide (Nano-TiO) is extensively utilized across various industries and has the capacity to penetrate human tissues through multiple biological barriers. The HaCaT cell line, as one of human immortalized keratinocytes, is usually used as a model for studying skin drug toxicology. The objective was to assess the toxic effects of nano-TiO on HaCaT cells and to trigger pyroptosis.

Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF-кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment.

Hepatocellular carcinoma (HCC) is the sixth most prevalent malignant tumor. Hepatocellular carcinogenesis is closely linked to apoptosis, autophagy, and inflammation. Diosmetin and chrysin, are two flavonoid compounds, exhibit anti-inflammatory and anticancer properties.

The hidden RNA viruses in (cockroaches and termites).

The insect order (cockroaches and termites) has drawn substantial research attention for their dietary habits and lifestyle of living with or around humans. In the present study, we focused on the discovery of RNA viruses hidden in insects using the publicly available RNA sequencing datasets. Overall, 136 distinctive RNA viruses were identified from 36 species, of which more than 70 % were most closely related to the invertebrate-associated viral groups within , , , , , , , , and .

Neuroprotective effect of emodin on Aβ-induced cytotoxicity in PC12 cells involves Nrf2/GPX4 and TLR4/p-NF-κB/NLRP3 pathways.

The present study aims to investigate the neuroprotective effects of emodin in Alzheimer's disease (AD). PC12 cells were used to explore the underlying mechanism and were incubated with Aβ for 24 h as the model group, incubated with emodin at different concentrations (2.5, 5, 10 μM) as the drug administration groups.

Neuroprotection of macamide in a mouse model of Alzheimer's disease involves Nrf2 signaling pathway and gut microbiota.

The underlying mechanisms of macamide's neuroprotective effects in Alzheimer's disease (AD) were investigated in the paper. Macamides are considered as unique ingredients in maca. Improvement effects and mechanisms of macamide on cognitive impairment have not been revealed.

Baicalin inhibits monosodium urate crystal-induced pyroptosis in renal tubular epithelial cell line through Panx-1/P2X7 pathways: Molecular docking, molecular dynamics, and in vitro experiments.

Pyroptosis is a programmed cell death process that frequently occurs in many diseases, including hyperuricemic nephropathy (HN). In HN, a range of stimuli mediates inflammation, leading to the activation of inflammasomes and the production of gasdermin D (GSDMD). Baicalin (BA), a natural flavonoid renowned for its antioxidant and anti-inflammatory properties, was investigated for its role in HN in this study.

Exploring the construction of urban artificial light ecology: a systematic review and the future prospects of light pollution.

Artificial light at night (ALAN) is rapidly growing and expanding globally, posing threats to ecological safety. Urban light pollution prevention and control are moving toward urban artificial light ecology construction. To clarify the need for light ecology construction, this work analyzes 1690 articles on ALAN and light pollution and 604 on ecological light pollution from 1998 to 2022.

Carboxylated mesoporous carbon hollow spheres for the efficient solid-phase microextraction of aromatic amines.

An efficient and stable fiber coating is of great importance for solid-phase microextraction (SPME). In this study, carboxylated mesoporous carbon hollow spheres (MCHS-COOH) were developed as an efficient SPME coating of polar aromatic amines (AAs) for the first time. The MCHS-COOH coating material with high specific surface area (1182.

Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.

Aim: Inflammation and apoptosis are main pathological processes that lead to the development of hyperuricemic nephropathy (HN). This study aims to explore whether baicalin (BA) and baicalein (BAI) can relieve the damage through PI3K/AKT/NF-κB signal pathway and provide more reliable and precise evidence for the treatment of HN.

Methods: HN mice were induced by yeast extract with potassium oxonate (PO), and HK-2 cells were induced by monosodium urate (MSU).

Neuroprotective effects of macamide from maca ( Walp.) on corticosterone-induced hippocampal impairments through its anti-inflammatory, neurotrophic, and synaptic protection properties.

The present study aims to investigate the protective effects of -(3-methoxybenzyl)-(9,12,15)-octadecatrienamide (M 18:3) on corticosterone-induced neurotoxicity. A neurotoxic model was established by subcutaneous injection of corticosterone (40 mg per kg bw) for 21 days. Depressive behaviors (the percentage of sucrose consumption, the immobility time in the forced swimming test, and the total distance in the open field test) were observed.

-(3-Methozybenzyl)-(9,12,15)-octadecatrienamide from maca ( Walp.) ameliorates corticosterone-induced testicular toxicity in rats.

This study investigated the protective effects of maca ethanol extract (EEM) and N-(3-methozybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (M 18:3) on corticosterone (CORT)-induced testicular toxicity. Male Wistar rats were divided into 5 groups. Except for the control group, CORT (40 mg per kg·bw) was injected subcutaneously for 21 consecutive days to induce testicular toxicity.

Safety evaluation and protective effects of ethanolic extract from maca (Lepidium meyenii Walp.) against corticosterone and HO induced neurotoxicity.

Maca has been traditionally used to enhance sexual behavior and fertility. Recently, maca's neuroprotective effects have been reported. The purpose of this study was to investigate whether the ethanol extract of maca (EEM) (100 mg/kg/bw, 200 mg/kg/bw, 400 mg/kg/bw, p.

Protective effects of macamides from Walp. against corticosterone-induced neurotoxicity in PC12 cells.

Maca has attracted considerable attention owing to its neuroprotective effects and . Macamides, a series of nonpolar and long-chain fatty acid -benzylamides, are considered unique constituents in maca. This study investigated the protective effects of ethanol extracts of maca (EEM) and macamides on corticosterone-induced (CORT) neurotoxicity in rat pheochromocytoma (PC12) cells.

Aerial parts of maca (Lepidium meyenii Walp.) as functional vegetables with gastrointestinal prokinetic efficacy in vivo.

Lepidium meyenii Walp. (maca) has been utilized in the Andean region because of its edibleness and medicinal value. The aerial parts of maca (APM) were analyzed for protein, total sugar, vitamins, amino acids, and minerals and its characteristic active ingredients at five different growth stages.

Magnetic and electric bulge-test instrument for the determination of coupling mechanical properties of functional free-standing films and flexible electronics.

For the first time a novel multi-field bulge-test instrument which enables measurements of the biaxial mechanical properties and electro-magnetic-mechanical coupling effect of free-standing films in external magnetic/electric fields was proposed. The oil pressure was designed with two ranges, 0-1 MPa for elastic small deformation and 0-7 MPa for plastic/damage large deformation. A magnetic field that was horizontal and uniform in the film plane was supplied by a hollow cylindrical magnet.