Clinical outcome and influencing factors of differentiated thyroid cancer with biochemical incomplete response.

Purpose: The aim of our study was to investigate the clinical outcomes and predictive factors in patients with biochemical incomplete response (BIR) after initial radioiodine therapy (RAI).

Materials & Methods: This retrospective study enrolled 198 patients with BIR from two institutions and stratified them into a training cohort (Qingdao cohort, n = 144) and an external validation cohort (Beijing cohort, n = 54). The patients were classified as having incomplete response (IR) or non-IR disease at the final follow-up.

Clinical outcome and influencing factors of differentiated thyroid cancer patients with radioiodine-refractory lung metastasis.

Purpose: A subset of patients with differentiated thyroid cancer and lung metastases (DTC-LM) may progress to radioiodine-refractory (RAIR) disease, which is associated with a poor prognosis. This study aimed to investigate the clinical outcomes and potential risk factors associated with RAIR disease in DTC-LM patients.

Methods: 177 DTC-LM patients who underwent radioiodine (RAI) therapy at our center were retrospectively analyzed.

Strain-Induced Intrinsic Constraint Boosts Slow-Thermalization and Fast-Transfer of Carriers in FAPbI Quantum Dot Solar Cells.

Formamidinium lead iodide quantum dots (FAPbI QDs) are extensively utilized in photovoltaic applications due to their superior optoelectronic characteristics. Nonetheless, the weak ionic bonds within their soft lattice structure lead to structural deformation, which causes a disordered charge distribution of FAPbI QDs. Stress engineering not only can mitigate the inherent soft lattice by reinforcing ion bonds but also can promote electron localization, thus enhancing charge carrier transfer.

Beam quality improvement for small-channel coherent beam combining with laser beams arranged along non-uniform Fermat spiral.

We propose a non-uniform Fermat spiral (NFS) array for small-channel coherent beam combining. Owing to the non-uniform array density and the changing distances between two consecutive channels, the combined beam quality is naturally improved by the NFS array. All the factors affecting the combined beam quality were analyzed in detail, comparing with the hexagon array and the uniform Fermat spiral (UFS) array.

Case Report: Gastric intramural hematoma with acute upper gastrointestinal bleeding in a child.

Gastric hematoma is an exceptionally rare condition in pediatric patients. It is characterized by the accumulation of blood within the gastric wall, resulting in the formation of a mass. Coagulopathy is the most common cause of gastric hematoma, although other etiologies include gastric ulcer, amyloidosis, pancreatitis, and splanchnic vascular aneurysms.

Nrf2 deficiency enhances oxidative stress and promotes susceptibility to tinnitus in mice.

Tinnitus is a prevalent and distressing medical symptom, and no effective pharmacological treatment currently exists. Despite significant advances, tinnitus remains a scientific enigma. To explore the molecular underpinnings of tinnitus, we developed a noise-induced tinnitus model in mice and utilized metabolomics to identify key differences in metabolic pathways.

1,25-D3 Protects Diabetic Brain Injury Through GLP-1R/PI3K/Akt Pathway by Experimental and Molecular Docking Studies.

Diabetes can cause an increase in intracellular glucose, leading to neuronal damage and microvascular dysfunction. Neuroprotective agents 1,25-dihydroxyvitamin D3 (1,25-D3) can reduce neurological complications. The main purpose of this study is to evaluate the levels of inflammatory factors and vascular protective factors in streptozotocin (STZ)-induced diabetic rats and determine whether 1,25-D3 can protect the rat brains from hyperglycemia through the glucagon-like peptide-1 (GLP-1)R/PI3K/AKT signal pathway.

Self-powered, touchless, interface-friendly cellulose fabric-based sensor via electrostatic flocking strategy.

As digital transformation accelerates globally, safeguarding personal data privacy has become increasingly important. Nonetheless, residual fingerprints from password entry pose a subtle yet significant risk for privacy leaks due to their persistence. Herein, by engineering micro-feathered triboelectric surfaces, incorporating fabric electrodes, and employing electrostatic flocking technologies.

Bioinspired Tunable Helical Fiber-Shaped Strain Sensor with Sensing Controllability for the Rehabilitation of Hemiplegic Patients.

Fiber-based strain sensors, as wearable integrated devices, have shown substantial promise in health monitoring. However, current sensors suffer from limited tunability in sensing performance, constraining their adaptability to diverse human motions. Drawing inspiration from the structure of the spiranthes sinensis, this study introduces a unique textile wrapping technique to coil flexible silver (Ag) yarn around the surface of multifilament elastic polyurethane (PU), thereby constructing a helical structure fiber-based strain sensor.

Electrostatic Harmonization for Superior Charge Extraction at Interface for Stable High-Efficiency FAPbI Quantum Dots Solar Cells.

Organic-inorganic formamidinium lead triiodide (FAPbI) hybrid perovskite quantum dots (QDs) have garnered considerable attention in the photovoltaic field due to their narrow bandgap, exceptional environmental stability, and prolonged carrier lifetime. Unfortunately, their insulating ligands and surface vacancy defects pose significant obstacles to efficient charge transfer across device interfaces. In this work, an electrostatic harmonization strategy at the interface using a donor-acceptor dipole molecular attachment to achieve enhanced charge separation capabilities on the QD surface is ventured.

Surface Doping to Suppress Iodine Ion Migration for Stable FAPbI Perovskite Quantum Dot Solar Cells.

Formamidine lead iodide (FAPbI) quantum dots (QDs) have attracted great attention as a new generation of photovoltaic material due to their long carrier diffusion length, benign ambient stability, and light-harvesting ability. However, its large surface area with inherent thermodynamic instability and highly defective ionic termination are still major obstacles to fabricating high-performance devices. Herein, a metallic ion dopant is developed to post-treat FAPbI QDs immediately after their fabrication by using a metal-glutamate salt solution.

Prognostic value of pre-ablation stimulated thyroglobulin in children and adolescents with differentiated thyroid cancer.

Aim: To investigate the prognostic value of pre-ablation stimulated thyroglobulin (ps-Tg) in children and adolescents with persistent differentiated thyroid cancer (DTC) following initial radioiodine therapy (RAI).

Materials & Methods: Patients were classified into "no clinical evidence of disease" (NED), "biochemical persistent disease" (BPD), and "structural/functional persistent disease" (S/FPD) groups, based on their therapeutic response to initial RAI. BPD patients were further categorized as incomplete response (IR) or Non-IR; S/FPD patients were categorized as remission or Non-remission.

Green interface optimization strategy based on allium mongolicum regel extract for enhanced alkaline Al-air battery performance.

Aqueous aluminum (Al)-air batteries (AABs) are gaining significant attention due to their excellent theoretical performance. However, the self-corrosion of the aluminum anode reduces anodic efficiency and battery capacity, limiting the broad commercial application of AABs. Herein, we propose the utilizing Allium Mongolicum Regel (AMR) extract as a green electrolyte additive to optimize the Al anode/electrolyte interface in alkaline AABs.

The Long-Term Effect of Cochlear Implantation on Tinnitus: A Systematic Review and Meta-Analysis.

Objective: This systematic review investigates the long-term effect of cochlear implantation (CI) on clinical outcomes in tinnitus patients with sensorineural hearing loss (SNHL).

Database Sources: PubMed, Embase, and the Cochrane Library were searched from inception to 30 April 2024. Manual searches of reference lists supplemented these searches when necessary.

Prognostic factors in children and adolescents with differentiated thyroid cancer treated with total thyroidectomy and radioiodine therapy: a retrospective two-center study from China.

Purpose: This two-center study aimed to explore the main prognostic factors affecting the final disease status in children and adolescents with differentiated thyroid cancer (caDTC) following total thyroidectomy and radioiodine therapy (RAIT).

Materials And Methods: All caDTC patients from two centers in the period from 2004-2022 were retrospectively included. At the last follow-up, the patients' disease status was assessed and classified as an incomplete response (IR) or as an excellent or indeterminate response (EIDR).

Construction Au/FAPbI Schottky Heterojunction towards a High-Speed Electron Transfer Channel for High-Performance Perovskite Quantum Dot Solar Cells.

Formamidinium lead triiodide quantum dot (FAPbI QD) exhibits substantial potential in solar cells due to its suitable band gap, extended carrier lifetime, and superior phase stability. However, despite great attempts toward reconfiguring the surface chemical environment of FAPbI QDs, achieving the optimal efficiency of charge carrier extraction and transfer in cells remains a challenge. To circumvent this problem, we selectively introduced Au/FAPbI Schottky heterojunctions by reducing Au to Au and subsequently anchoring them on the surface of FAPbI QDs, which acts as a light-harvesting layer and establishes high-speed electron transfer channels (Au dot ↔ Au dot).

Velocity field and turbulence structure of the meandering flow produced by alternating deflectors.

Meandering flow can be formed during the advance of natural rivers by the scouring of river banks. However, this phenomenon is not common in artificial cement channels. This study used experimental scouring terrain data for a numerical simulation to study the meandering flow pattern formed between double alternating deflectors in a straight channel.

Insights into ThB: Stability, Electronic Structure, and Interaction.

The interaction between nonmetal and metal atoms has attracted great interest in the development of organometallic compounds and their promising applications. In this study, we explored the interaction between boron and thorium atoms, based on the stable BTh coordination compound, by employing density functional theory calculations. We elucidated the stability and geometries of the BTh coordination compound and revealed the electron transfer from the metal atom Th to B, which is evidenced by the natural bond orbital calculations.

Inhibition of HSP20 Ameliorates Steatotic Liver Disease by Stimulating ERK2-Dependent Autophagy.

HSP20 emerges as a novel regulator of autophagy in the heart. Nonetheless, the detailed function of HSP20 in the liver and its effect on autophagy remain unknown. Here, we observed that HSP20 expression is increased in liver tissues from mice and patients with metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease.

Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury.

Efficient clearance and degradation of apoptotic cardiomyocytes by macrophages (collectively termed efferocytosis) is critical for inflammation resolution and restoration of cardiac function after myocardial ischemia/reperfusion (I/R). Here, we define secreted and transmembrane protein 1a (Sectm1a), a cardiac macrophage-enriched gene, as a modulator of macrophage efferocytosis in I/R-injured hearts. Upon myocardial I/R, Sectm1a-KO mice exhibited impaired macrophage efferocytosis, leading to massive accumulation of apoptotic cardiomyocytes, cardiac inflammation, fibrosis, and consequently, exaggerated cardiac dysfunction.

Preparation and performance study of waterproof and breathable layer of alginate/aramid-based fabrics and flame-retardant multilayer combination.

Alginate fibers have excellent flame-retardant properties and make up for other material defects by blending. To investigate the influence of the blending ratio of alginate fibers on the flame-retardant properties of waterproof and breathable layers for firefighting suits, this paper utilizes the needle-punching and hot-pressing nonwoven reinforcement processes to prepare waterproof and breathable layers based on alginate/aramid base cloths and conducts a series of performance tests on them. The results show that the char residue content of alginate blended base cloth is significantly improved relative to pure aramid, and the addition of alginate fibers to the base cloth of the waterproof and breathable layer improves its flame retardancy and thermal stability.

Electrochemical oxidative cyclization of -allylamides for the synthesis of CF-containing benzoxazines and oxazolines.

The introduction of trifluoromethyl (-CF) groups into compounds is a common synthetic strategy in organic chemistry. Commonly used methods for introducing trifluoromethyl groups are limited by harsh reaction conditions, low regioselectivity, or the need for excess reagents. In this study, a facile electrochemical oxidative and radical cascade cyclization of -(2-vinylphenyl)amides for the synthesis of CF-containing benzoxazines and oxazolines was obtained.

Long-term prognostic analysis of children and adolescents with differentiated thyroid carcinoma based on therapeutic response to initial radioiodine therapy.

Background: The clinical features and prognosis of children and adolescents with differentiated thyroid carcinoma (caDTC) are different from that of adults. Postoperative radioiodine therapy (RIT) was recommended for some intermediate and high risk caDTC patients. The objective of this study was to evaluate the long-term prognosis of pediatric caDTC patients with different responses to initial RIT and to explore the related influencing factors.

An improved model for target detection and pose estimation of a teleoperation power manipulator.

Introduction: A hot cell is generally deployed with a teleoperation power manipulator to complete tests, operations, and maintenance. The position and pose of the manipulator are mostly acquired through radiation-resistant video cameras arranged in the hot cell. In this paper, deep learning-based target detection technology is used to establish an experimental platform to test the methods for target detection and pose estimation of teleoperation power manipulators using two cameras.

Exploration of the etiology of single small subcortical infarctions using high-resolution vessel wall MRI.

Objective: We aimed to explore imaging indicators for diagnosing the etiology of single small subcortical infarctions (SSI) using high-resolution vessel wall imaging (HR-VWI).

Methods: Patients with acute isolated subcortical cerebral infarction were prospectively enrolled and classified as having large artery atherosclerosis (LAA), stroke of undetermined etiology (SUD), or small artery disease (SAD). The infarct information, the cerebral small vessel disease (CSVD) score, morphological characteristics of the lenticulostriate arteries (LSAs), and plaque characteristics were compared between the three groups.