Cuproptosis is involved in small intestinal toxicity in the paraffins during pregnancy.

Short-chain chlorinated paraffins (SCCPs) is generally regarded as an emerging persistent organic pollutant. So far, small intestine injury in the progeny of adult mice exposed to SCCPs during pregnancy has not yet been the subject of any research. To investigate potential intestinal injury in the progeny of adult mice exposed to SCCPs during pregnancy.

Socioeconomic gradients in cancer survivorship mortality pathways and interventions.

This commentary examines socioeconomic disparities in mortality among cancer survivors, drawing insights from a cohort study demonstrating that unhealthy lifestyles mediate 13.5%-28.7% of socioeconomic status (SES)-related mortality differences.

VeA is involved in anti-tumor activity by regulating adenylosuccinate lyase to mediate the synthesis of Acadesine in endophytic .

Acadesine (AICAR) is a promising candidate for new drugs in Phase III clinical trials. The purpose of this study is to analyse the steps in the biosynthesis pathway of AICAR. Our previous study found that overexpression of , a gene encoding a global regulator, significantly increased AICAR production of endophytic HB1-J1 and the anti-tumor activity of its extracts.

Naphthalimide-based luminogens with bright aggregative-state emission: High-contrast blue-shift mechanofluorochromism and application in ink-free secure information storage.

In recent decades, with the advancement of the field of organic luminescent materials, mechanofluorochromic materials with aggregation-induced emission (AIE) properties have become a pioneering research hotspot due to their excellent photophysical properties and wide range of applications. Herein, a series of carbazole-naphthalamide (CN-R) type derivatives containing different benzene ring substituents and their isomers were designed and synthesized. The fluorescence of the donor-acceptor type derivatives could be modulated through the introduction of diverse benzene ring substituents.

Ecological Risk Assessment and Source Identification of Potential Toxic Elements in Farmland Soil of Nanyang Basin, China.

This study investigated spatial distribution features and ecological risks of eight potential toxic elements (Cr, Ni, Cu, Zn, Pb, As, Cd, and Hg) in surface soil samples (0-20 cm) collected from farmland in the Nanyang Basin, China. This research also aimed to analyze the sources of these elements. Its findings revealed that the mean contents of Cr, Ni, Cu, Zn, Pb, As, Cd, and Hg were 54.

Protein Ubiquitination Modification in Pulmonary Fibrosis.

Pulmonary fibrosis (PF) is a chronic, progressive fibrotic interstitial lung disease characterized by a high incidence and mortality rate, which encompasses features, such as diffuse alveolar inflammation, invasive fibroblast activation, and uncontrolled extracellular matrix (ECM) deposition. Beyond the local pathological processes, PF can be better understood in light of interorgan communication networks that are involved in its progression. Notably, pulmonary inflammation can affect cardiovascular, renal, hepatic, and neural functions, highlighting the importance of understanding these systemic interactions.

Healthy lifestyle factors outweigh influence of APOE genetic risk on extending cognitively healthy life expectancy among Chinese older adults: evidence from a nationwide cohort study.

Introduction: Understanding the interplay between genetic factors and lifestyle choices in cognitive health is crucial for enhancing late-life quality. This study examines the effects of Apolipoprotein E (APOE) genotypes and healthy lifestyles on life expectancy with and without cognitive impairment (CI) in Chinese older adults.

Methods: Data from 6488 participants aged at least 65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) were analyzed using continuous-time three-state Markov models.

The effect of China's Integrated Medical and Social Care Policy on functional dependency and care deficits in older adults: a nationwide quasi-experimental study.

Background: With population ageing, the development and implementation of pragmatic care strategies for older people with functional dependencies have become critical issues. In alliance with WHO's Integrated Care for Older People framework, China implemented the Integrated Medical and Social Care Policy (IMSCP) in several cities in 2016. This study aims to evaluate whether and to what extent the IMSCP has achieved its primary objectives of reducing functional dependency and addressing care needs in Chinese older adults aged 65 years and older.

Background Values of Soil Heavy Metals in the Huang-Huai-Hai Plain in Henan Province, China.

Due to the continuous lack of specific background values (BVs) for soil heavy metals in the Huang-Huai-Hai Plain in Henan province (HPHP), many researchers have used soil heavy BVs specific to Henan Province (HP) or Fluvisols of China (FC) as reference criteria to assess soil heavy metal pollution. However, spatial differences in the soil heavy metal BVs between HPHP, HP, and FC, as well as within the HPHP, remain uncertain, affecting the reliability of evaluation results. A total of 897 surface soil samples were collected from the HPHP, with 336 and 561 samples collected from the southern and northern parts of the Shaying River, respectively.

Caring for the "Osteo-Cardiovascular Faller": Associations between Multimorbidity and Fall Transitions among Middle-Aged and Older Chinese.

It is still uncertain how multimorbidity patterns affect transitions between fall states among middle-aged and older Chinese. Data were obtained from China Health and Retirement Longitudinal Study (CHARLS) 2011-2018. We utilized latent class analysis to categorize baseline multimorbidity patterns, Markov multi-state model to explore the impact of multimorbidity characterized by condition counts and multimorbidity patterns on subsequent fall transitions, and Cox proportional hazard models to assess hazard ratios of each transition.

Associations Between Brominated Flame Retardant Exposure and Depression in Adults: A Cross-Sectional Study.

Background: Brominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the link between exposure to mixtures of BFRs and depression in the general population.

Methods: To analyze the association between exposure to BFRs and depression in the population, nationally representative data from the National Health and Nutrition Examination Survey (NHANES; 2005-2016) were used.

Oral microbiota as a biomarker for predicting the risk of malignancy in indeterminate pulmonary nodules: a prospective multicenter study.

Background: Determining the benign or malignant status of indeterminate pulmonary nodules (IPN) with intermediate malignancy risk is a significant clinical challenge. Oral microbiota-lung cancer (LC) interactions have qualified oral microbiota as a promising non-invasive predictive biomarker in IPN.

Materials And Methods: Prospectively collected saliva, throat swabs, and tongue coating samples from 1040 IPN patients and 70 healthy controls across three hospitals.

Associations between housing quality and sarcopenia among older adults: evidence from China and India.

Objectives: Housing is an important social determinant of health. However, limited studies have focused on the relationship between housing quality and sarcopenia, especially in low- and middle-income countries. This study aims to examine the association between housing quality and sarcopenia in older adults in China and India.

Health Risk Assessment for Potential Toxic Elements in the Soil and Rice of Typical Paddy Fields in Henan Province.

The accumulation of potential toxic elements in agricultural soil and rice is of particular concern in China. However, studies on the risk assessment of these elements in regional soil-rice systems remain limited. The aim of this study is to evaluate the pollution status and potential health risk of potential toxic elements in typical paddy soil and rice in Henan Province.

Global burden of metabolic dysfunction-associated steatotic liver disease attributable to high fasting plasma glucose in 204 countries and territories from 1990 to 2021.

Metabolic dysfunction-associated steatotic liver disease (MASLD) brings heavy clinical and economic burdens to patients worldwide. High fasting plasma glucose (HFPG) was proven to be an important modifiable risk factor. However, the global burden distribution of HFPG-attributable MASLD has not been fully studied.

Health literacy and falls among community-dwelling older people in China: is there a sex difference?

Background: Health literacy is one of the important determinants of healthy aging, yet few studies have focused on the association between health literacy and falls.

Aims: This study aims to explore the relationship between health literacy and falls, with a focus on sex differences among older people in China.

Methods: This cross-sectional study enrolled 2,144 older people aged ≥ 60 years from Shandong Province, China in 2021.

Understanding regulating effects of protein-anionic octenyl succinic anhydride-modified starch interactions on the structural, rheological, digestibility and release properties of starch.

Background: Proteins and anionic octenyl succinic anhydride (OSA)-modified starch (OSA-starch) are common ingredients in food systems. The interactions between OSA-starch and protein are found to alter the structural and functional properties of the protein-OSA-starch complexes. In this regard, the close understanding of the relationship among the molecular interactions between whey protein isolate (WPI) and OSA-high amylose corn starch (HAS), structure changes and rheological, digestibility and release properties of WPI-OSA-HAS was investigated.

Effects of OSA-starch-fatty acid interactions on the structural, digestibility and release characteristics of high amylose corn starch.

This study investigated the effects of octenyl succinic anhydride (OSA)-starch-fatty acid (FA) interactions on the structural, digestibility and release characteristics of high amylose corn starch (HAS). FTIR and XRD analysis showed that the hydrophobic interaction between HAS and FA promoted the covalent binding between OSA and HAS. With the increasing of the FA chain length, the complex index, degree of substitution, R and relative crystallinity of OSA-HAS-FA increased first and then decreased, whereas the first-order rate coefficient and percentage of digested in infinite time showed an opposite trend.

The bi-directional relationships between diversified leisure activity participation and cognitive function in older adults in China: separating between-person effects from within-person effects.

Objective: To examine the bi-directorial association between diversified leisure activity participation and cognitive function over a 7-year period.

Methods: Data analyzed was from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a large-scale longitudinal national study. The baseline survey was conducted in 2011 with follow-up every three years.

Bi-directional association between outdoor or social activities and cognitive function: do the PM exposure catalyze the detrimental inactivity-poor cognition cycle?

Background: Previous research has shown that lack of leisure activities, either outdoor or social activities, impedes cognitive function. However, the interrelationship between poor cognition and deficient activities is understudied. In addition, whether exposure to air pollution, such as PM, can accelerate the detrimental 'inactivity-poor cognition' cycle, is worthy of investigation.

Development of a ferroptosis-based molecular markers for predicting RFS in prostate cancer patients.

The goal of this study was to develop a ferroptosis-based molecular signature that can predict recurrence-free survival (RFS) in patients with prostate cancer (PCa). In this study, we obtained ferroptosis-related genes (FRGs) in FerrDb database and clinical transcriptome data in TCGA database and GEO database. Consensus cluster analysis was used to identify three molecular markers of ferroptosis in PCa with differential expression of 40 FRGs, including PD-L1 expression levels.