Risk assessment of temporary pacing for cardiac arrest after cardiopulmonary bypass-assisted cardiovascular surgery: A case-control study.

Objective: Cardiac arrest happens in 0.7%-5.2% patients after cardiovascular surgery, and cases with asystole or severe bradycardia need timely temporary pacing.

The Bidirectional Association between Psoriatic Disease and Uveitis: An Updated Meta-Analysis.

Background: In the past decade, there has been growing research interest in the association between psoriatic diseases and uveitis due to the potential pathogenetic links. However, observational studies have reported inconsistent results.

Methods: We thoroughly searched PubMed, Embase, and Web of Science for cohort or case-control studies investigating the bidirectional association between psoriatic diseases (psoriasis and psoriatic arthritis) and uveitis.

Three new limonoids with high oxidation from the fruits of .

Agledulines L-N (), three previously undescribed limonoids with the A/D-ring-seco structural characteristics and high degree oxidation, along with the three reported compounds (), were isolated from the fruits of . The structures of were elucidated by NMR data, HRESIMS, ECD spectra, and circular dichroism exciton chirality method. The furan rings in and were oxidized to -hydroxy-butene lactone moiety, and the tautomerism of hemiacetal C-21 contributed to the disappearance of NMR signals in the segments.

Psychological capital and subjective well-being: a multi-mediator analysis among rural older adults.

Background: Amid global demographic changes, understanding factors associated with subjective well-being among rural older adults has gained prominence. This study investigated the pathways linking psychological capital and subjective well-being, focusing on the mediating roles of subjective socioeconomic status, justice perceptions, and marital satisfaction.

Methods: Data from the 2017 China General Social Survey were analyzed using a multi-mediation approach.

Nonmissile Penetrating Brain Injury Caused by Rebar: A Case Report.

The primary treatment for a penetrating brain injury is craniotomy because of the presence of a foreign body. Craniocerebral computed tomography is the main imaging method for this condition, and cranial reconstruction is an important basis for formulating relevant surgical protocols. It is necessary to use antibiotics to prevent infection after surgery.

Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments.

Research into the pathogenesis of inflammatory skin diseases, including dermatitis and psoriasis, has yielded significant advancements in the last decades. The identification of age, gender, and genetic factors contributing to these complex conditions has been pivotal in developing novel pharmacological and technological treatments. This review delves into the molecular underpinnings of psoriasis, examining current therapies and promising investigational agents.

Tea Polyphenol-Derived Carbon Dots Alleviate Abdominal Aortic Aneurysm Progression by Mitigating Oxidative Stress and Ferroptosis.

Abdominal aortic aneurysm (AAA) is a cardiovascular disease with potentially fatal consequences, yet effective therapies to prevent its progression remain unavailable. Oxidative stress is associated with AAA development. Carbon dots have reactive oxygen species-scavenging activity, while green tea extract exhibits robust antioxidant properties.

Ultrasound Pretreatment for Enhancing Fine and Ultrafine Flake Graphite Flotation Beneficiation.

With the severe depletion of coarse flake graphite (a critical raw material) resources, developing and utilizing fine and ultrafine graphite resources have recently attracted attention. Froth flotation is a widely used technique for the initial enrichment of graphite; however, the flotation selectivity decreases significantly along with particle size reduction. Ultrasound pretreatment would be a promising method to improve the flotation of fine particles.

Effects of wearing masks during COVID-19 pandemic on the composition and diversity of skin bacteria and fungi in medical workers.

Background: Although studies have shown that wearing masks can affect the skin microbiome, more detailed and comprehensive research on wearing masks needs to be further explored.

Objective: This study aimed to characterize the influence of mask wearing on the diversity and structural characteristics of the facial skin microbial community of medical staff during the COVID-19 pandemic by means of metagenomic sequencing (mNGS).

Methods: A total of 40 samples were taken by swabbing the cheek in the 2 × 2 cm area before and after wearing the masks.

Happiness and mental health of older adults: multiple mediation analysis.

Introduction: This study aims to explore the influence mechanism of older adult mental health. As the aging population grows, the mental health of older adults becomes a significant public health and social issue, with happiness serving as a key dimension of mental health.

Methods: This study utilizes public data from CGSS to investigate the relationship between happiness and mental health, with Process V4.

Physical activity's impact on rural older adult health: The multiple mediating effects of education, income, and psychological capital.

Introduction: This study aims to explore the influence mechanism of rural older adult health. By examining the mediating roles of education, income, and psychological capital in physical activity's impact on health, this study provides a reference for lifestyle interventions to improve the health level of rural older adults.

Methods: The analysis was conducted on a sample of 1778 rural older adults from CGSS2017, and data were analyzed using PROCESS V4.

d-Inositol Derivatives with Multidrug Resistance Reversal Activities from the Fruits of .

Chisosiamols A-K (-), 11 new d--inositol derivatives, along with a known analogue () were isolated from the fruits of . Their planar structures and relative configurations were elucidated by the comprehensive application of spectroscopic methods, especially from the characteristic coupling constants, and H-H COSY spectra. The absolute configurations of the d--inositol core were determined using the ECD exciton chirality and X-ray diffraction crystallographic analytical methods.

The Relationship Between College Students' Interpersonal Relationship and Mental Health: Multiple Mediating Effect of Safety Awareness and College Planning.

Purpose: The research intends to find the internal influence mechanism of interpersonal relationship on college students' mental health. College students have many mental health problems, which can easily lead to extreme events. It is of great research value to explore the relationship among interpersonal relationship, safety awareness, college planning, and mental health.

Current understanding on the role of CCT3 in cancer research.

Chaperonin containing TCP1 Subunit 3 (CCT3) is an important member of the chaperone protein family, providing a favorable environment for the correct folding of proteins in cell division, proliferation, and apoptosis pathways, which is involved in a variety of biological processes as well as the development and invasion of many malignant tumors. Many malignancies have been extensively examined with CCT3. It is presently used as a possible target for the treatment of many malignancies since it is not only a novel biomarker for the screening and diagnosis of different tumors, but it is also closely associated with tumor progression, prognosis, and survival.

A/D-rings-seco limonoids from the fruits of Aglaia edulis and their bioactivities.

Agledulines A-K, eleven previously undescribed limonoids, including eight biogenic A/D-rings-seco limonoid analogs (agledulines A-H), one D-ring-seco limonoid (agleduline I) and two A-ring-seco limonoids with a rare Δ moiety (agledulines J-K), together with twelve reported limonoids, were isolated from the fruits of Aglaia edulis. Their structures were determined by NMR data, HRESIMS, X-ray diffraction, ECD spectra and the CD exciton chirality method. Observably, the absolute configurations of agleduline A, agleduline C and nymania 2 were unambiguously elucidated by single-crystal X-ray diffraction analyses.

Limonoids with Diverse Oxidation Patterns of C-12 Indicating a Complete Ring C- Biogenetic Pathway from .

Munrolins A-Q (-), 17 new ring C- limonoids with diverse oxidative patterns of C-12, together with nine known analogues (-), were isolated from the CHCl extract of . The planar structures were elucidated by a combination of 1D and 2D NMR and HR-MS analyses, while the absolute configurations were confirmed by ECD calculations and single-crystal X-ray diffraction. Munrolins A () and B () were first identified as ring C- limonoids with a 12,13-ether bridge moiety.

Aglatestine A, a Rearranged Limonoid with a 3/6/6 Tricarbocyclic Framework from the Fruits of .

Aglatestine A (), an unprecedented 3/6/6 tricarbocyclic limonoid framework along with four biogenic A/D- limonoid analogues with rare β-substituents at C-6 (), was discovered from the fruits of . The structures of along with their absolute configurations were clarified using methods of HRMS(ESI), NMR, electronic circular dichroism, X-ray diffraction crystallography, and quantum chemical calculations. The plausible biogenetic speculation suggested that an electrophilic cyclization between C-1 carbocation from acetolysis and electron-rich C-5 from enolization of C═O of may play a key role.

Topography-Dependent Effective Contact Line in Droplet Depinning.

The mobility of a fakir state droplet on a structured surface is fundamentally determined by the effective length of a microscopic contact line. However, it is largely unknown how the surface topography determines the effective contact line length. Based on the direct measurement of droplet adhesion force and the visualization of contact line, this work shows that effective contact line length is topography dependent as opposed to prior notion.

The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants.

Cohesin, a multisubunit protein complex, is required for holding sister chromatids together during mitosis and meiosis. The recruitment of cohesin by the sister chromatid cohesion 2/4 (SCC2/4) complex has been extensively studied in Saccharomyces cerevisiae mitosis, but its role in mitosis and meiosis remains poorly understood in multicellular organisms, because complete loss-of-function of either gene causes embryonic lethality. Here, we identified a weak allele of Atscc2 (Atscc2-5) that has only minor defects in vegetative development but exhibits a significant reduction in fertility.

The in-plane crashworthiness of multi-layer regularly arranged circular honeycombs.

The in-plane crashworthiness of multi-layer regularly arranged circular honeycombs are investigated numerically at  = 1-250 m/s, with aim to disclose the influences of / ratio and crushing velocity, . A novel evaluation methodology of crashworthiness and a new mechanical term, most appropriate strain, are put forward, which results in some new evaluation parameters. The theoretical analysis shows the most appropriate strain is a significant parameter for measuring the crashworthiness.

Magnetic Resonance Imaging-Guided Drug Delivery to Breast Cancer Stem-Like Cells.

The feasibility of detecting breast cancer stem-like cells (BCSCs) with magnetic resonance imaging using extradomain-B of fibronectin (EDB-FN)-specific peptide (APT )-conjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (APT -TCL-SPIONs) is previously demonstrated. Here, doxorubicin (Dox)-loaded APT -TCL-SPIONs (Dox@APT -TCL-SPIONs) are generated and their theranostic ability in a BCSC xenograft mouse model is assessed. The Dox@APT -TCL-SPIONs enable more efficient delivery of Dox to tumors than nontargeted Dox@TCL-SPIONs.

Spontaneous Spreading of a Droplet: The Role of Solid Continuity and Advancing Contact Angle.

Spontaneous spreading of a droplet on a solid surface is poorly understood from a macroscopic level down to a molecular level. Here, we investigate the effect of surface topography and wettability on spontaneous spreading of a water droplet. Spreading force is measured for a suspended droplet that minimizes interference of kinetic energy in the spontaneous spreading during its contact with solid surfaces of discontinuous (pillar) and continuous (pore) patterns with various shapes and dimensions.

Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells.

Choline kinase-α (Chk-α) and autophagy have gained much attention, as they relate to the drug-resistance of breast cancer. Here, we explored the potential connection between Chk-α and autophagy in the mechanisms driving to tamoxifen (TAM) resistance, in estrogen receptor positive (ER+) breast cancer cells (BCCs). Human BCC lines (MCF-7 and TAM-resistant MCF-7 (MCF-7/TAM) cells) were used.

Targeted Therapy for Breast Cancer Stem Cells by Liposomal Delivery of siRNA against Fibronectin EDB.

Targeted therapy for breast cancer stem cell (BCSC): A novel liposomal system (APTEDB -LS-siRNA(EDB) ) that enables simultaneous targeting and knockdown of extra domain B of fibronectin (EDB-FN) shows potent therapeutic efficacy in the BCSC-derived tumors in vivo.