CoO/ graphite activated sodium percarbonate: Enhanced interfacial adsorption facilitates efficient oxidative degradation of organic pollutants.

Herein, graphite-supported cobalt oxide material (CoO/Gr) was synthesized via supramolecular self-assembly. The as-prepared nanocomposite exhibits nanowires-like morphology featuring CoO nanoparticles uniformly dispersed in graphite matrix. This material can effectively activate sodium percarbonate (SPC), leading to the efficient removal of Acid Orange 7 (AO7) from simulated wastewater.

Effect of pre-weaning glycyl-glutamine feeding on diarrhea rate, hindgut fermentation, antioxidant stress capability, and fecal microbiota in calves.

Glycyl-glutamine (Gly-Gln, GQ) is formed by the dehydration-condensation reaction of glycine and glutamine. Different studies have shown a positive effect of GQ on gut health and growth performance in early neonatal animals. We evaluated oral GQ effects in Holstein calves on growth (body weight, average dairy gain), fecal score, diarrhea rate, serum biomarkers (antioxidants/inflammation/biochemistry/amino acids), and hindgut parameters (fermentation and microbiota).

Development of a clinical prediction model for sensitivity to combination therapy of Bcl-2 inhibitors and hypomethylating agents in elderly/unfit patients with acute myeloid leukemia.

Objective: This study aims to develop a clinical prediction model for sensitivity to Bcl-2 inhibitors combined with hypomethylating agents (HMAs) in elderly/unfit patients with acute myeloid leukemia (AML).

Methods: Clinical data, including French-American-British (FAB) classification, chromosomal karyotype, and second-generation sequencing results, were retrospectively collected from consecutive elderly/unfit patients with AML treated with Bcl-2 inhibitors in combination with HMAs between September 2019 and March 2024. Treatment efficacy was assessed in all patients.

Dairy intake, plasma metabolome, and risk of type 2 diabetes in a population-based cohort.

Background: Whether dairy intake is related to type 2 diabetes (T2D) remains unclear, as does potential metabolic mechanisms for this association.

Objectives: We aimed to examine the association between high dairy intake and risk of T2D and identify plasma metabolites reflecting dairy intake.

Methods: This prospective cohort study included 26,461 Swedish individuals recruited between 1991 and 1996 and followed up until 31 December, 2020, with available data on dairy intake at baseline and linked registers.

Improved genetic algorithm based on bi-level co-evolution for coverage path planning in irregular region.

Irregular region coverage path planning has been widely applied in robot search tasks and has attracted a lot of attention. This study proposes an improved genetic algorithm based on bi-level co-evolution for coverage path planning (IGA-CPP) in irregular region. The processes of the method are region decomposition, sub-region selection and coverage path generation.

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species.

The lateral septum (LS) is a midline, subcortical structure that is a critical regulator of social behaviors. Mouse studies have identified molecularly distinct neuronal populations within the LS, which control specific facets of social behavior. Despite its known molecular heterogeneity in the mouse and critical role in regulating social behavior, comprehensive molecular profiling of the human LS has not been performed.

METTL14-mediated mA modification of DDIT4 promotes its mRNA stability in aging-related idiopathic pulmonary fibrosis.

Although N-methyladenosine (mA) may be related to the pathogenesis of fibrotic process, the mechanism of mA modification in aging-related idiopathic pulmonary fibrosis (IPF) remains unclear. Three-milliliter venous blood was collected from IPF patients and healthy controls. MeRIP-seq and RNA-seq were utilized to investigate differential mA modification.

Differences in risk factor profiles for peripheral artery disease compared to coronary, cerebral and carotid artery.

The aim of this study was to evaluate the greatest drivers for development of lower extremity peripheral artery disease (PAD) in relation to coronary, precerebral, or cerebral artery disease This prospective study (Malmö Diet and Cancer study) included 26,681 participants. The diagnosis of incident PAD, coronary artery disease (CoAD), atherothrombotic ischemic stroke (IS) free from atrial fibrillation or flutter, and carotid artery disease (CaAD) was validated. A modified Lunn-McNeil competing risk analysis was performed to compare the Hazard Ratio (HR) strength of PAD in relation to CoAD, IS, or CaAD.

Nanoscale visualization of crack tips inside molten corium-concrete interaction debris using 3D-FIB-SEM with multiphase positional misalignment correction.

Characterizing molten corium-concrete interaction (MCCI) fuel debris in Fukushima reactors is essential to develop efficient methods for its removal. To enhance the accuracy of microscopic observation and focused ion beam microsampling of MCCI fuel debris, we developed a 3D focused ion beam scanning electron microscopy technique with a multiphase positional misalignment correction method. This system automatically aligns voxel positions, corrects contrast and removes artifacts from a series of over 500 scanning electron microscopy images.

Theoretical Analysis of Contact Angle and Contact Angle Hysteresis of Wenzel Drops on Superhydrophobic Surfaces.

Although understanding the wetting behavior of solid surfaces is crucial for numerous engineering applications, the mechanisms driving the motion of Wenzel drops on rough surfaces remain incompletely clarified. In this study, the contact angle and contact angle hysteresis of Wenzel drops on superhydrophobic surfaces are investigated from a thermodynamic perspective. The free energy of the system is theoretically analyzed, thereby determining the equilibrium contact angle.

Ultra-processed food consumption, plasma metabolite profile, and risk of all-cause and cause-specific mortality in a population-based cohort.

Background & Aims: Epidemiological evidence on ultra-processed food (UPF) and cause-specific mortality remains limited and mixed. Molecular mechanisms underlying UPF intake and mortality remain unexplored. This study aimed to evaluate the associations between UPF consumption, metabolic signatures, and all-cause, premature, and cause-specific mortality.

Adulthood weight changes, body mass index in youth, genetic susceptibility and risk of atrial fibrillation: a population-based cohort study.

Background: Epidemiological evidence on weight change and atrial fibrillation (AF) remains limited and inconsistent. Previous studies on body mass index (BMI) in youth and AF rarely considered subsequent BMI. This study aimed to assess the associations of AF with weight change and BMI in youth, as well as modified effect by genetic susceptibility of AF.

Single-cell landscape revealed immune characteristics associated with disease phases in brucellosis patients.

A comprehensive immune landscape for infection is crucial for developing new treatments for brucellosis. Here, we utilized single-cell RNA sequencing (scRNA-seq) of 290,369 cells from 35 individuals, including 29 brucellosis patients from acute ( = 10), sub-acute ( = 9), and chronic ( = 10) phases as well as six healthy donors. Enzyme-linked immunosorbent assays were applied for validation within this cohort.

Interplay of Food-Derived Bioactive Peptides with Gut Microbiota: Implications for Health and Disease Management.

Bioactive peptides (BPs) are protein fragments with beneficial effects on metabolism, physiology, and diseases. This review focuses on proteolytic BPs, which are produced by the action of gut microbiota on proteins in food and have demonstrated to influence the composition of gut microbes. And gut microbiota are candidate targets of BPs to alleviate oxidative stress, enhance immunity, and control diseases, including diabetes, hypertension, obesity, cancer, and immune and neurodegenerative diseases.

Distinct electrochemical and metabolic responses of anode respiring bacteria to sulfamethoxazole in microbial fuel cells coupled with constructed wetlands.

The influence of sulfamethoxazole (SMX) on the electrochemical activity, bacterial community, and metabolic state of anode respiring microbes was investigated in constructed-wetland-coupled microbial fuel cells (CW-MFCs). Results suggested that SMX shortened the acclimatisation period and enhanced the maximal power density of the CW-MFC at 0.1 mg/L.

Noninvasive models for the prediction of liver fibrosis in patients with chronic hepatitis B.

Objective: To evaluate the diagnostic accuracy of aspartate aminotransferase(AST)/ alanine transaminase (ALT), AST to platelet ratio index (APRI), fibrosis-4 score (FIB-4) and gamma-glutamyl transpeptidase to platelet count ratio (GPR) for hepatic fibrosis in patients with chronic hepatitis B (CHB).

Methods: A total of 1210 CHB patients who underwent liver biopsy were divided into two groups: patients with no significant fibrosis (control group) and patients with significant fibrosis, and routine laboratory tests were retrospectively included. Logistic regression models were used for the prediction, and the area under the receiver operating characteristic (AUROC) was used to assess the diagnostic accuracy.

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species.

The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in neurodevelopmental disorders including schizophrenia and autism spectrum disorder. Mouse studies have identified neuronal populations within the LS that express a variety of molecular markers, including vasopressin receptor, oxytocin receptor, and corticotropin releasing hormone receptor, which control specific facets of social behavior. Despite its critical role in regulating social behavior and notable gene expression patterns, comprehensive molecular profiling of the human LS has not been performed.

Depressive symptoms, parenting attitude, and violent discipline among caregivers of left-behind children in rural China: a cross-sectional study.

Background: The situation of mental health and discipline behaviors of left-behind children's caregivers were not optimistic in rural China. Caregivers' depression might increase the risk of using violent discipline. However, the specific ways in which depressive symptoms impact violent discipline have rarely been explored in rural areas.

Simultaneous immobilization of V and Cr availability, speciation in contaminated soil and accumulation in ryegrass by using Fe-modified pyrolysis char.

In this study, municipal waste pyrolytic char (PEWC) was prepared by pyrolysis from municipal solid waste extracted in landfills, and Fe-based modified pyrolytic char (Fe-PEWC) was prepared by modification. Focusing on the evaluation of the stabilization capacity of Fe-PEWC for vanadium (V) and chromium (Cr) in soils, the effects of PEWC addition on soil properties, bioavailability and morphological distribution of V and Cr, ryegrass growth, and V and Cr accumulation were thoroughly investigated. The results of pot experiment showed that the application of PEWC and Fe-PEWC significantly (P < 0.

Correlation analysis and predicting modeling of pyrolysis gas based on landfill excavated waste pyrolysis characteristics.

The contribution of excavated waste to waste management is multifaceted, including minimization, non-hazardous disposal, access to useable land resources, improved waste management techniques and public environmental awareness, consistent with recent circular economy initiatives. Pyrolysis can be converted into tar, pyrolysis gas and char with recyclable utilization, enriching the application of pyrolysis technology in the field of excavation waste. In this study, the pyrolysis system includes horizontal tube furnace, gas collection device and Micro GC.

A neutrophil extracellular trap-related risk score predicts prognosis and characterizes the tumor microenvironment in multiple myeloma.

Multiple myeloma (MM) is a distinguished hematologic malignancy, with existing studies elucidating its interaction with neutrophil extracellular traps (NETs), which may potentially facilitate tumor growth. However, systematic investigations into the role of NETs in MM remain limited. Utilizing the single-cell dataset GSE223060, we discerned active NET cell subgroups, namely neutrophils, monocytes, and macrophages.