Publications by authors named "Youyong Tang"
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke.
Acta Pharm Sin B
September 2024
Article Synopsis
- Heat waves are increasing, leading to higher instances of heat stroke, which causes serious liver damage due to unique mechanisms like heat cytotoxicity and inflammation, contributing to higher death rates.
- Research suggests that the dysfunction of liver cells called Kupffer cells, particularly a specific subtype (Clec4F/CD206), may be linked to ferroptosis—a type of cell death—triggered by heat stroke.
- Targeting a stress response protein (HMOX-1) in these Kupffer cells could reduce inflammation and liver injury during heat stroke, presenting new opportunities for treatments.
TRPV1/cPLA2/AA pathway contributes to ferroptosis-mediated acute liver injury in heatstroke.
Int Immunopharmacol
September 2024
With the increasing frequency of global heatwaves, the incidence of heatstroke (HS) is significantly rising. The liver plays a crucial role in metabolism and is an organ highly sensitive to temperature. Acute liver injury (ALI) frequently occurs in patients with HS, yet the exact mechanisms driving ALI in HS are still unknown.
View Article and Find Full Text PDFEffects of NGS-based PGT-a for idiopathic recurrent pregnancy loss and implantation failure: a retrospective cohort study.
Syst Biol Reprod Med
October 2023
Article Synopsis
- * Results showed that iRPL couples using PGT-A had significantly higher implantation rates, clinical pregnancy rates, and live birth rates compared to those who underwent conventional IVF/ICSI, particularly in women of advanced maternal age (AMA ≥35 years).
- * No significant differences were found in clinical outcomes for younger iRPL couples or for either age group of iRIF couples, suggesting PGT-A may be
Background: tRNA derived small RNAs (tRFs) have recently received extensive attention; however, the effects of tRFs in exosome as biomarkers has been less studied. The objective of this study was to validate novel diagnostic exosomal tRFs with sensitivity and specificity for non-small cell lung cancer (NSCLC).
Methods: Exosomes extracted from plasma of NSCLC patients and healthy individuals were identified by transmission electron microscopy (TEM), qNano and western blots.
Serum exosomal miR-377-3p and miR-381-3p as diagnostic biomarkers in colorectal cancer.
Future Oncol
March 2022
This study aimed to identify specific and sensitive exosomal miRNAs in diagnosing patients with colorectal cancer (CRC). Serum exosomes were isolated from 175 CRC patients and 172 healthy donors by ultracentrifugation and identified by transmission electron microscopy, nanoparticle tracking analysis and western blotting. Exosomal miRNA expression was detected by quantitative PCR and the results analyzed by receiver operating characteristic analysis to illuminate the diagnostic accuracy.
View Article and Find Full Text PDFArticle Synopsis
- Exosomes from cancer cells contain tumor-specific molecules, facilitating communication with nearby or distant cells, and are being explored for their potential use in cancer diagnosis, particularly through long non-coding RNAs (lncRNAs).
- The study focused on identifying circulating exosomal lncRNAs—specifically FOXD2-AS1, NRIR, and XLOC_009459—from the serum of patients with colorectal cancer (CRC) compared to healthy individuals using advanced isolation and validation techniques.
- The findings reveal that these lncRNAs are significantly elevated in CRC patients, showing good diagnostic accuracy (AUC values between 0.660 and 0.743) individually, and an improved combined AUC of 0.736 for CRC diagnosis
Tumor-Derived Exosomal miR-620 as a Diagnostic Biomarker in Non-Small-Cell Lung Cancer.
J Oncol
December 2020
Background: Evidence has suggested the functional role of exosomal miRNAs in cancer diagnosis. This study aimed to determine whether the serum exosomal biomarkers can improve the diagnosis of patients with non-small-cell lung cancer (NSCLC).
Materials And Methods: The exosomes were extracted from the serum of NSCLC patients ( = 235) and healthy donors ( = 231) using ultracentrifugation and then were evaluated by using transmission electron microscopy, qNano, and western blotting.
Tumor-Derived Exosomal miRNAs as Diagnostic Biomarkers in Non-Small Cell Lung Cancer.
Front Oncol
October 2020
Background: Delayed diagnosis is the main obstacle to improve prognosis of non-small cell lung cancer (NSCLC). Novel biomarkers for the diagnosis of NSCLC are urgently needed. This study aimed to identify the specific exosomal miRNAs with diagnostic and prognostic potential in NSCLC patients.
View Article and Find Full Text PDFCirculating serum exosomal miR-20b-5p and miR-3187-5p as efficient diagnostic biomarkers for early-stage non-small cell lung cancer.
Exp Biol Med (Maywood)
October 2020
The high mortality of non-small cell lung cancer (NSCLC) is mainly because the cancer has progressed to a more advanced stage before diagnosis. If NSCLC can be diagnosed at early stages, especially stage 0 or I, the overall survival rate will be largely improved by definitive treatment such as lobectomy. We herein validated two novel circulating serum ExmiRs as diagnostic biomarkers for early-stage NSCLC to fulfill the unmet medical need.
View Article and Find Full Text PDFCirculating Exosomal miR-150-5p and miR-99b-5p as Diagnostic Biomarkers for Colorectal Cancer.
Front Oncol
October 2019
Circulating exosomal miRNAs are potential non-invasive biomarkers for colorectal cancer. The present study aimed to validate the novel sensitive and specific exosomal miRNA biomarkers for diagnosing colorectal cancer (CRC). Exosomes isolated from the serum of CRC patients and healthy donors by ultracentrifugation were characterized using TEM, qNano, and immunoblotting.
View Article and Find Full Text PDFTumor-derived exosomal miRNA-320d as a biomarker for metastatic colorectal cancer.
J Clin Lab Anal
November 2019
Background: To identify specific exosomal microRNAs (miRNAs) as serum biomarkers for prediction of metastasis in patients with colorectal cancer (CRC).
Materials And Methods: Serum exosomes were isolated from patients with metastatic CRC (n = 34) and non-metastatic CRC (n = 108) by ultracentrifugation and characterized using transmission electron microscopy, qNano, and Western blot. Differential exosomal miRNAs were screened by sequencing and validated by qPCR in metastatic and non-metastatic CRC patients.