The sequelae of septic hip arthritis in children: a revised classification and case review.

Background: Existing classification systems for sequelae of pediatric septic arthritis of the hip (SAH) are notably complex. This study introduces a simplified radiographic classification-the Xi'an Honghui Hospital Paediatric Orthopaedic Classification (HHPO classification)-designed to enhance accuracy in treatment planning and prognostic evaluation.

Methods: A retrospective analysis was conducted involving 18 pediatric patients with SAH.

Trends and hotspots in epiphyseal injury studies over 2 decades: A bibliometric analysis.

Purpose: This review provides guidance and ideas for researchers through a comprehensive and comparative analysis of the present state, trends, and hotspots in the epiphyseal injury literature in the last 2 decades.

Methods: We searched the Web of Science core database to explore the epiphyseal injury literature from January 1, 2003 to December 31, 2022. (1) Search parameters: #1.

Diluent-Induced Liquid Crystalline Domain Ordering Synergistically Enhances Thermal Conductivity and Electrical Insulation of Polymers.

With the increasing demand for high-performance electrical equipment, particularly in power semiconductors, it is crucial to develop packaging materials with excellent insulation, thermal conductivity, and thermal stability. However, achieving simultaneous enhancement of the thermal conductivity and dielectric strength remains a significant challenge. In this work, a phenyl glycidyl ether diluent was introduced to induce ordered liquid crystalline epoxy films, yielding substantial electro-thermal improvements.

Gelatin/hyaluronic acid-based forming hydrogel promotes wound regeneration by the synergy of ROS-scavenging and pro-healing activity.

The development of advanced hydrogel dressings that integrate biocompatibility, antioxidant activity and dynamic adaptability remains critical for addressing the complex demands of modern wound management. In this study, we designed a multinetwork hydrogel (GHrCT) through synergistic strategies: A robust covalent network is constructed through photocrosslinked gelatin methacryloyl, while a secondary dynamic network formed via hydrogen bonds and electrostatic interactions is established among dopamine-modified hyaluronic acid (HD), tannic acid (TA) and recombinant collagen type III (rhCol III). Through a series of experiments, we systematically characterized key properties of the hydrogel, including its microscopic morphology, swelling behavior, rheological characteristics and mechanical strength.

Cholesterol confers resistance to Apatinib-mediated ferroptosis in gastric cancer.

Background: Gastric cancer is the fifth leading cause of cancer-related deaths worldwide. Apatinib is a third-line treatment for gastric cancer. However, the development of resistance significantly limits its efficacy, and effective and safe strategies to overcome Apatinib resistance remain elusive.

Simultaneous Cholesterol Reduction and cGAS-STING Pathway Amplification: A Novel Enzyme Cascade Strategy against Tumor Resistance.

Drug resistance remains a significant challenge in cancer therapy, and current strategies typically involve the use of P-glycoprotein (P-gp) inhibitors. Unfortunately, the rigid surface of drug-resistant cancer cell membranes and the immunosuppressive tumor microenvironment severely limit the therapeutic efficacy. Here, we report a novel nanoparticle platform named DOX@CM@M, which can efficiently reverse tumor resistance through cholesterol depletion, while robustly enhancing antitumor effects by activating innate immunity.

Elastin dose-controlled mineral deposition by masking collagen-binding sites for calcium ions.

Bone and blood vessel mineralization are representative of physiological and pathological mineralization, respectively. Collagen and elastin play important roles in regulating mineralization. Minerals are more readily deposited on elastin than on collagen.

Development of a clinical prediction model for poor treatment outcomes in the intensive phase in patients with initial treatment of pulmonary tuberculosis.

Background: A prediction model is hereby developed to identify poor treatment outcomes during the intensive phase in patients with initial treatment of pulmonary tuberculosis (TB).

Methods: The data of inpatients with pulmonary TB were collected from a tertiary hospital located in Southeastern China from July 2019 to December 2023. The included patients were divided into the modeling group and the validation group.

CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells.

FOXP3-expressing regulatory T (T) cells play a pivotal role in maintaining immune homeostasis and tolerance, with their activation being crucial for preventing various inflammatory responses. However, the mechanisms governing the epigenetic program in T cells during their dynamic activation remain unclear. In this study, we demonstrate that CXXC-finger protein 1 (CXXC1) interacts with the transcription factor FOXP3 and facilitates the regulation of target genes by modulating H3K4me3 deposition.

Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target.

Prostate cancer (PCa) is the second most common cancer in men worldwide, and understanding its molecular mechanisms is crucial for developing effective treatment strategies. SIRT7, a NAD+-dependent histone deacetylase, has emerged as a key regulator in PCa progression due to its roles in chromatin remodeling, DNA repair, and transcriptional regulation. Analysis of 492 PCa samples from The Cancer Genome Atlas (TCGA) via cBioPortal revealed that high SIRT7 expression is associated with poor prognosis in PCa patients.

Core-Shell Nanoparticles with Sequential Drug Release Depleting Cholesterol for Reverse Tumor Multidrug Resistance.

Multidrug resistance (MDR) facilitates tumor recurrence and metastasis, which has become a main cause of chemotherapy failure in clinical. However, the current therapeutic effects against MDR remain unsatisfactory, mainly hampered by the rigid structure of drug-resistant cell membranes and the uncontrolled drug release. In this study, based on a sequential drug release strategy, we engineered a core-shell nanoparticle (DOX-M@CaP@ATV@HA) depleting cholesterol for reverse tumor MDR.

Molting of laying hens can activate AMPK- lipophagy - lipid metabolism pathway and improve intestinal digestion and absorption.

Poultry molting is a natural phenomenon, and process that improves the physiological function of laying hens. In this study, artificial intervention was used to induced molting (IM) in aged hens and improve their egg- laying performance. Jejunal lipophagy and lipid metabolism data were analyzed to elucidate the regulatory mechanisms by which the intestine affects egg production performance, particularly through the lens of digestion and absorption processes.

Programmable Macrophage Vesicle Based Bionic Self-Adjuvanting Vaccine for Immunization against Monkeypox Virus.

The emergence of monkeypox has become a global health threat after the COVID-19 pandemic. Due to the lack of available specifically treatment against MPV, developing an available vaccine is thus the most prospective and urgent strategy. Herein, a programmable macrophage vesicle based bionic self-adjuvanting vaccine (AM@AEvs-PB) is first developed for defending against monkeypox virus (MPV).

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis.

Mesoderm induction is a crucial step for vascular cell specification, vascular development and vasculogenesis. However, the cellular and molecular mechanisms underlying mesoderm induction remain elusive. In the present study, a chemically-defined differentiation protocol was used to induce mesoderm formation and generate functional vascular cells including smooth muscle cells (SMCs) and endothelial cells (ECs) from human induced pluripotent stem cells (hiPSCs).

Research Progress of Metal-Organic Frameworks as Drug Delivery Systems.

Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in the biomedical field based on the advantages of internal porosity, customizable porosity, and facile surface modification. This review examines the utilization of MOFs in drug delivery systems, focusing on the research progress from the aspects of coloading drug systems, intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, and multifunctional living carriers.

TRPV1/cPLA2/AA pathway contributes to ferroptosis-mediated acute liver injury in heatstroke.

With the increasing frequency of global heatwaves, the incidence of heatstroke (HS) is significantly rising. The liver plays a crucial role in metabolism and is an organ highly sensitive to temperature. Acute liver injury (ALI) frequently occurs in patients with HS, yet the exact mechanisms driving ALI in HS are still unknown.

Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia.

Aims: Long non-coding RNA (LncRNA) small nucleolar RNA host gene 18 (SNHG18) has been widely implicated in cancers. However, little is known about its functional involvement in vascular diseases. Herein, we attempted to explore a role for SNHG18 in modulating vascular smooth muscle cell (VSMC) contractile phenotype and injury-induced neointima formation.

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy.

The etiology of diabetic nephropathy (DN) is complex, and the incidence is increasing year by year. The patient's kidney showed oxidative stress damage, increasing active oxygen species (ROS) content, and vasoconstriction. Due to poor drug solubility and low renal accumulation, the current treatment regimens have not effectively alleviated glomerulopathy and other kidney damage caused by DN.

Research hotspots for pediatric fractures from 2017 to 2022: A bibliometric and visual analysis via Citespace.

Objective: This review provides guidance and ideas for researchers through a comprehensive and comparative analysis of the present state, trends, and hotspots in the pediatric fracture literature over the past 6 years.

Methods: We used Citespace 6.1.

RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective.

Musashi1 and Musashi2 are RNA-binding proteins originally found in drosophila, in which they play a crucial developmental role. These proteins are pivotal in the maintenance and differentiation of stem cells in other organisms. Research has confirmed that the Musashi proteins are highly involved in cell signal-transduction pathways such as Notch and TGF-β.

Dual-targeted nanoparticles with removing ROS inside and outside mitochondria for acute kidney injury treatment.

Mitochondrial oxidative stress and inflammation are the main pathological features of acute kidney injury (AKI). However, systemic toxicity of anti-inflammatory drugs and low bioavailability of antioxidants limit the treatment of AKI. Here, the lipid micelle nanosystem modified with l-serine was designed to improve treatment of AKI.

4-Methyl-2-(2-methyl-anilino)benzoic acid.

The title compound, CHNO, was obtained by the reaction of 2-chloro-4-methyl-benzoic acid and -toluidine using 2-eth-oxy-ethanol as solvent. Crystals of the title compounds were obtained from crystallization in acetone. The mol-ecule in the crystal is twisted with a dihedral angle between the aromatic rings of 50.

The relationship between sublingual immunotherapy for allergic rhinitis and the risk of symptoms in patients with COVID-19 infection.

To evaluated the risk ratio of Allergic rhinitis (AR) people on the symptoms after COVID-19 infection, and explored the relationship between AR and the symptoms after COVID-19 infection. An observational study was performed of people from outpatient department of the Hospital of Chengdu University of Chinese Medicine. Participants completed an electronic survey and between January 10 to January 20, 2023.