Spatiotemporal Anomaly Detection in Distributed Acoustic Sensing Using a GraphDiffusion Model.

Distributed acoustic sensing (DAS), which can provide dense spatial and temporal measurements using optical fibers, is quickly becoming critical for large-scale infrastructure monitoring. However, anomaly detection in DAS data is still challenging owing to the spatial correlations between sensing channels and nonlinear temporal dynamics. Recent approaches often disregard the explicit sensor layout and instead handle DAS data as two-dimensional images or flattened sequences, eliminating the spatial topology.

Toxicity of Consecutive Treatments Combining Synthetic and Organic Miticides to Nurse Bees of .

, an ectoparasitic mite of honey bees, is a major contributor to global colony declines. To manage infestations, beekeepers frequently apply both synthetic and organic miticides-sometimes in combination. While much attention has been given to foragers' pesticide exposure, nurse bees are also at risk due to direct miticide contact and prolonged exposure to residuals in hive matrices.

Size matters: Establishing a cut-off for rectal neuroendocrine neoplasm to predict recurrence and standardize surveillance guidelines.

Objectives: This study aimed to identify risk factors for recurrence of rectal neuroendocrine neoplasms, establish a cut-off size for recurrence prediction, and standardize surveillance guidelines.

Methods: This retrospective study analyzed patients diagnosed with rectal neuroendocrine neoplasm at Samsung Medical Center from January 2007 to July 2021. Tumors were classified according to World Health Organization and European Neuroendocrine Tumor Society guidelines.

A comparison of soft tissue outcomes in skeletal Class II malocclusion: Anterior segmental osteotomy vs. non-surgical orthodontic treatment.

Objective: Temporary anchorage devices (TADs) have considerably reduced the need for anterior segmental osteotomy (ASO) in patients with Class I malocclusion. Most previous studies have been published before the widespread use of TADs, thus warranting new guidelines for determining the optimal approach for surgery and orthodontic treatment. This study aimed to establish guidelines on the choice between ASO and non-ASO (NASO) based on soft tissue considerations.

Miniaturized side-firing intracardiac photoacoustic imaging catheter for monitoring radiofrequency ablation.

In this paper, we introduce a miniaturized intracardiac photoacoustic (PA) imaging system based on a phased-array intracardiac echocardiography catheter. This PA imaging system enhances imaging feedback during radiofrequency (RF) ablation for atrial fibrillation (A-fib) by providing ablation-induced lesion mapping. The PA imaging catheter with a 4-mm diameter was designed, featuring flexible tip for bending and navigation through the vessels.

Neuregulin-induced HER3 activation drives migration in head and neck squamous cell carcinoma via HER2 and FAK signaling pathways.

Purpose: To investigate the role of neuregulin (NRG) signaling in promoting head and neck squamous cell carcinoma (HNSCC) migration through HER3-dependent pathways and to assess the therapeutic potential of targeting the NRG/HER3 axis in mitigating perineural invasion.

Methods: NRG-driven migration was studied using DRG co-culture, wound healing assays, and HER3 inhibition (shRNA, AV-203). The biological function and biochemical effects of the HER3/HER2/FAK axis in response to NRG were analyzed via phosphorylation assays, knockdown, western blotting, and cell staining for protein expression.

Annual Therapeutic Drug Monitoring in Patients with Inflammatory Bowel Disease During Infliximab Maintenance Therapy: Balancing Efficacy with Risk of Pharmacokinetic Failure.

Background And Aims: Recent studies indicate that proactive therapeutic drug monitoring (TDM) can improve clinical outcomes in patients with inflammatory bowel disease (IBD) treated with infliximab. Repetitive infliximab trough level (IFX TL) measurements for proactive TDM may increase patient inconvenience and medical costs. Therefore, we aimed to determine the optimal interval for TDM during infliximab maintenance therapy in patients with IBD.

Rapid spread of Amitraz resistance linked to a unique T115N mutation in the octopamine receptor of Varroa mites in Korea.

The Varroa mite, Varroa destructor, is an ectoparasitic pest of Western honey bees and poses a significant threat to apiculture. In Korea, widespread fluvalinate resistance has increased reliance on amitraz as an alternative acaricide. This study identified a novel mutation, T115N, in the β2-adrenergic-like octopamine receptor gene (OctβR) and confirmed its role in amitraz resistance.

Population Pharmacokinetic Model for the Use of Intravenous or Subcutaneous Infliximab in Patients with Inflammatory Bowel Disease: Real-World Data from a Prospective Cohort Study.

Background/aims: Infliximab treatment failure in patients with inflammatory bowel disease may result from sub-optimal infliximab trough level. An understanding of pharmacokinetics (PKs) is important to maintain an optimal trough level. PK studies of the switch to subcutaneous (SC) infliximab from intravenous (IV) infliximab using real-world data are lacking.

Clinical utility of complete blood count indices in pediatric MOG antibody-associated disease.

Objective: The purpose of this study was to analyze the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in pediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Methods: Retrospective review of medical record was performed to analyze association among complete blood count (CBC) indices and clinical characteristics of pediatric MOGAD patients.

Results: 61 patients were included in the analysis.

IFN-γ-Induced intestinal epithelial cell-type-specific programmed cell death: PANoptosis and its modulation in Crohn's disease.

Background: Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) and is considered a Th1-mediated disease, supported by the over-expression of interferon-gamma (IFN-γ) in the intestinal lamina propria. IFN-γ has a pleiotropic effect on the intestinal epithelial cells (IECs), suggesting that IFN-γ-induced responses may differ between epithelial cell types.

Methods: We established human small intestinal organoids (enteroids) derived from non-IBD controls and CD patients.

Endoscopic Features of Gastrointestinal Amyloidosis: A Proposed Endoscopic Classification.

Background/aims: Gastrointestinal amyloidosis (GIA) is a common condition that presents with a variety of endoscopic features. However, the classification of these endoscopic features of GIA and its clinical implications have not been investigated.

Methods: The endoscopic findings of 127 patients with GIA were reviewed and classified by three experienced endoscopists.

Enteroscopic Balloon Dilation in Small Bowel Stricturing Crohn's Disease: Long-Term Outcomes and Risk Factors for Surgery in a Single-Center Prospective Observational Study.

Background And Aims: The long-term outcomes of enteroscopic balloon dilation for small bowel strictures in patients with Crohn's disease are not well understood. Although Crohn's strictures can be classified into web-like, ulcerated, and spindle-shaped strictures based on endoscopic findings, the outcomes of enteroscopic balloon dilation according to the shape of Crohn's strictures have not been analyzed. The primary outcome was to evaluate the cumulative surgery-free rate, and the secondary outcome was to evaluate the risk factor for subsequent surgery after enteroscopic balloon dilation.

Data transformation of unstructured electroencephalography reports by natural language processing: improving data usability for large-scale epilepsy studies.

Introduction: Electroencephalography (EEG) is a popular technique that provides neurologists with electrographic insights and clinical interpretations. However, these insights are predominantly presented in unstructured textual formats, which complicates data extraction and analysis. In this study, we introduce a hierarchical algorithm aimed at transforming unstructured EEG reports from pediatric patients diagnosed with epilepsy into structured data using natural language processing (NLP) techniques.

Predicting orthognathic surgery results as postoperative lateral cephalograms using graph neural networks and diffusion models.

Orthognathic surgery, or corrective jaw surgery, is performed to correct severe dentofacial deformities and is increasingly sought for cosmetic purposes. Accurate prediction of surgical outcomes is essential for selecting the optimal treatment plan and ensuring patient satisfaction. Here, we present GPOSC-Net, a generative prediction model for orthognathic surgery that synthesizes post-operative lateral cephalograms from pre-operative data.

AI-Driven View Guidance System in Intra-Cardiac Echocardiography Imaging.

Intra-cardiac echocardiography (ICE) is a crucial imaging modality used in electrophysiology (EP) and structural heart disease (SHD) interventions, providing real-time, high-resolution views from within the heart. Despite its advantages, effective manipulation of the ICE catheter requires significant expertise, which can lead to inconsistent outcomes, especially among less experienced operators. To address this challenge, we propose an AI-driven view guidance system that operates in a continuous closed-loop with human-in-the-loop feedback, designed to assist users in navigating ICE imaging without requiring specialized knowledge.

Enhanced broadband quantum efficiency in LWIR T2SL detectors with guided-mode resonance structure.

Type-II superlattice (T2SL) detectors are emerging as key technologies for next-generation long-wavelength infrared (LWIR) applications, particularly in the 8-14 µm range, offering advantages in space exploration, medical imaging, and defense. A major challenge in improving quantum efficiency (QE) lies in achieving sufficient light absorption without increasing the active layer (AL) thickness, which can elevate dark current and complicate manufacturing. Traditional methods, such as thickening the absorber, are limited by the short carrier lifetime in T2SLs, necessitating alternative solutions.

A study on the compressive strength of three-dimensional direct printing aligner material for specific designing of clear aligners.

Background: The demand for orthodontic treatment using clear aligners has been gradually increasing because of their superior esthetics compared with conventional fixed orthodontic therapy. This study aimed to evaluate and compare the compressive strength of three-dimensional direct printing aligners (3DPA) with that of conventional thermo-forming aligners (TFA) to determine their clinical applicability. In the experimental group, the 3DPA material TC-85 (TC-85 full) was used to create angular protrusions called rectangular pressure areas (RPA).

Enhancing Clinical Applications by Evaluation of Sensitivity and Specificity in Whole Exome Sequencing.

The cost-effectiveness of whole exome sequencing (WES) remains controversial due to variant call variability, necessitating sensitivity and specificity evaluation. WES was performed by three companies (AA, BB, and CC) using reference standards composed of DNA from hydatidiform mole and individual blood at various ratios. Sensitivity was assessed by the detection rate of null-homozygote (N-H) alleles at expected variant allelic fractions, while false positive (FP) errors were counted for unexpected alleles.

3,6-Anhydro-L-galactose suppresses mouse lymphocyte proliferation by attenuating JAK-STAT growth factor signal transduction and G-S cell cycle progression.

Recombinant GH16B β-agarase-catalyzed liquefaction of 5-7 %(w/v) melted agarose at 50 °C completely hydrolyzed agarose into neoagarohexaose (NA6) and neoagarotetraose (NA4). Subsequent saccharification by recombinant GH50A β-agarase or recombinant GH50A β-agarase/recombinant GH117A α-neoagarobiose hydrolase at 35 °C converted NA6/NA4 into neoagarobiose (NA2) or 3,6-anhydro-L-galactose (L-AHG)/D-galactose, respectively. Purification of NA6/NA4 and NA2 was achieved by Sephadex G-15 column chromatography, while L-AHG was purified by Sephadex G-10, achieving ≥ 98 % purity.

Soft tissue paradigm based Treatment planning in skeletal class III.

Objectives: This study aimed to propose guidelines for the indications of non-extraction, extraction camouflage treatment, and orthognathic surgery by comparing the degree of soft tissue improvement effects. This comparison focused on changes in CKHA, a soft tissue indicator corresponding to the major hard tissue indicator, ANB.

Materials And Methods: Sixty-six patients, 25 males and 41 females, aged between 18 and 50 years and diagnosed with skeletal Class III malocclusion (ANB < 0°), were enrolled in the study.

Comparison between spectral-domain optical coherence tomography-based and partial coherence interferometry-based biometry.

We compared axial length (AL) measurements using spectral-domain optical coherence tomography (SD-OCT)-based and partial coherence interferometry (PCI)-based biometry in eyes with various chorioretinal diseases. Medical records were retrospectively analyzed in 123 eyes from 73 patients who underwent AL measurements using SD-OCT and PCI. AL values were highly consistent by both measurements (ICC = 0.

Subcutaneous Infliximab Concentration Thresholds for Mucosal and Transmural Healing in Patients With Crohn's Disease.

Background: Predose trough concentrations (C) of intravenous infliximab (IV-IFX) during maintenance therapy are associated with therapeutic outcomes in patients with Crohn's disease (CD). A subcutaneous formulation of infliximab (SC-IFX) has shown high C values due to its favourable pharmacokinetics.

Aims: To evaluate the association of C of SC-IFX with therapeutic outcomes and the threshold of SC-IFX C for achieving mucosal healing (MH) and transmural healing (TH) in patients with CD.

Development and Assessment of a Novel Ulcerative Colitis-Specific Quality of Life Questionnaire: A Prospective, Multi-Institutional Study.

Purpose: Interest in the quality of life (QoL) of patients with inflammatory bowel disease (IBD) has recently increased. Although measurement tools have been devised for IBD in general, there is no specific tool for measuring the QoL of patients with ulcerative colitis (UC). Therefore, we developed a QoL questionnaire specifically for patients with UC.