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Intra-cardiac echocardiography (ICE) is a crucial imaging modality used in electrophysiology (EP) and structural heart disease (SHD) interventions, providing real-time, high-resolution views from within the heart. Despite its advantages, effective manipulation of the ICE catheter requires significant expertise, which can lead to inconsistent outcomes, especially among less experienced operators. To address this challenge, we propose an AI-driven view guidance system that operates in a continuous closed-loop with human-in-the-loop feedback, designed to assist users in navigating ICE imaging without requiring specialized knowledge. Specifically, our method models the relative position and orientation vectors between arbitrary views and clinically defined ICE views in a spatial coordinate system. It guides users on how to manipulate the ICE catheter to transition from the current view to the desired view over time. By operating in a closed-loop configuration, the system continuously predicts and updates the necessary catheter manipulations, ensuring seamless integration into existing clinical workflows. The effectiveness of the proposed system is demonstrated through a simulation-based performance evaluation using real clinical data, achieving an 89% success rate with 6,532 test cases. Additionally, a semi-simulation experiment with human-in-the-loop testing validated the feasibility of continuous yet discrete guidance. These results underscore the potential of the proposed method to enhance the accuracy and efficiency of ICE imaging procedures.
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http://dx.doi.org/10.1109/TBME.2025.3533485 | DOI Listing |
Cell
September 2025
Centre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, UK; Fleming Initiative, Imperial College London, London W2 1NY, UK; Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. Electronic address:
Artificial intelligence (AI) models have been proposed for hypothesis generation, but testing their ability to drive high-impact research is challenging since an AI-generated hypothesis can take decades to validate. Here, we challenge the ability of a recently developed large language model (LLM)-based platform, AI co-scientist, to generate high-level hypotheses by posing a question that took years to resolve experimentally but remained unpublished: how could capsid-forming phage-inducible chromosomal islands (cf-PICIs) spread across bacterial species? Remarkably, the AI co-scientist's top-ranked hypothesis matched our experimentally confirmed mechanism: cf-PICIs hijack diverse phage tails to expand their host range. We critically assess its five highest-ranked hypotheses, showing that some opened new research avenues in our laboratories.
View Article and Find Full Text PDFAdv Mater
September 2025
Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.
Nanomedicine has shown remarkable promise in advancing tumor imaging and therapy through its ability to achieve targeted delivery, precision imaging, and therapeutic efficacy. However, translating these preclinical successes into clinical practice remains fraught with challenges, including inconsistent tumor targeting, off-target organ accumulation, and a lack of comprehensive understanding of in vivo behavior of nanomedicines. In this perspective, the current state of nanomedicine research is critically analyzed, emphasizing the translational bottlenecks and offering a forward-looking view on potential solutions.
View Article and Find Full Text PDFSci Rep
August 2025
College of Physical Education, Baicheng Normal University, Baicheng, Jilin, 137000, China.
This paper presents a novel system for optimizing Tai Chi movement training using computer vision and deep learning technologies. We developed a comprehensive framework incorporating multi-view pose estimation, temporal feature extraction, and real-time movement assessment to address the challenges of traditional Tai Chi instruction. The system employs spatial-temporal graph convolutional networks enhanced with attention mechanisms for accurate movement evaluation, combined with personalized feedback generation through augmented reality and multi-modal interfaces.
View Article and Find Full Text PDFMayo Clin Proc Digit Health
September 2025
PGxAI Inc., Palo Alto, CA.
Pharmacogenomics is entering a transformative phase as high-throughput "omics" techniques become increasingly integrated with state-of-the-art artificial intelligence (AI) methods. Although early successes in single-gene pharmacogenetics reported clear clinical benefits, many drug response phenotypes are governed by intricate networks of genomic variants, epigenetic modifications, and metabolic pathways. Multi-omics approaches address this complexity by capturing genomic, transcriptomic, proteomic, and metabolomic data layers, offering a comprehensive view of patient-specific biology.
View Article and Find Full Text PDFPET Clin
August 2025
Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, Canada.
This article reviews recent advancements in PET/computed tomography imaging, emphasizing the transformative impact of total-body and long-axial field-of-view scanners, which offer increased sensitivity, larger coverage, and faster, lower-dose imaging. It highlights the growing role of artificial intelligence (AI) in enhancing image reconstruction, resolution, and multi-tracer applications, enabling rapid processing and improved quantification. AI-driven techniques, such as super-resolution, positron range correction, and motion compensation, are improving lesion detectability and image quality.
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