Case report: surgery combined with a SOX adjuvant chemotherapy regimen for patients with gastric adenocarcinoma and hepatocellular carcinoma.

Advances in early tumor detection have led to an increase in the reported incidence of multiple primary cancers. However, the concurrent occurrence of gastric adenocarcinoma and hepatocellular carcinoma remains rare. We present the case of a 68-year-old male patient with chronic hepatitis B who was diagnosed with stage Ib liver cancer (T1bN0M0).

Laparoscopic management of transverse testicular ectopia with spermatic cord fusion: a case report.

Background: Transverse testicular ectopia (TTE) is a rare congenital anomaly where both testes descend through the same inguinal canal and are located on the same side. Cases with fused spermatic cords are particularly rare and present unique surgical challenges.

Case Description: We report the case of an 8-month-old male infant with bilateral cryptorchidism and an empty scrotum since birth.

Nursing vigilance in preventing catheter fragment migration: a dual case report of peripheral venous catheter fractures in pediatric practice.

Background: Indwelling venous catheters, including peripheral intravenous catheters (PIVCs), are vital in pediatric care for delivering medications and fluids. However, catheter fractures, though rare (incidence 0%-2.1%), pose serious risks such as pulmonary embolism or cardiac arrhythmias if fragments migrate.

The complex role and molecular mechanism of family with sequence similarity genes in cancer: a comprehensive review.

The family with sequence similarity (FAM) is a family of genes with unknown functions and similar sequences. However, recent studies have reported that many FAM members play important roles in the onset and progression of cancer. Specifically, the expression of this type of gene is abnormal in tissues and cells of different types of cancer and is related to the prognosis of cancer patients.

Exploring the mechanism of cinobufagin on gastric cancer based on proteomics, molecular dynamics, in vitro and in vivo experiment.

Cinobufagin as one of the primary bioactive components of Chansu, which is a widely used traditional remedy in China, has been employed in the treatment of various malignant tumors, including gastric cancer. However, its antitumor effects on gastric cancer and the underlying mechanisms have not yet been fully elucidated. This study aims to comprehensively investigate the effects of cinobufagin on AGS gastric cancer cells both in vitro and in vivo, and to further explore its mechanism of action.

ESCO2 promotes the proliferation of hepatocellular carcinoma through the PI3K/AKT/ mTOR signaling pathway.

Establishment of sister chromatid cohesion N-Acetyltransferase 2 () is a gene implicated in the establishment of sister chromatid cohesion (SCC) and cell proliferation. We aimed to explore how affects the proliferation of hepatocellular carcinoma (HCC). We analyzed ESCO2 expression levels and their association with clinical prognosis using the TCGA, HCCDB, and ICGC databases.

Corrigendum: partial quadrate lobectomy improves early outcomes of laparoscopic Kasai surgery in type III biliary atresia.

[This corrects the article DOI: 10.3389/fped.2025.

Right-sided descending colon with necrotizing enterocolitis: a rare case report.

Background: Anatomical variations of the colon are commonly reported, with the majority involving the right colon. However, anomalies affecting the left colon, particularly the descending colon, are rarely described in the literature.

Methods: We reviewed the clinical records of right-sided descending colon with necrotizing enterocolitis involvement at our hospital, detailing the patients' onset, imaging studies, complications, and treatment.

Synergistic chemotherapy and immunomodulatory effects of Quercetin in cancer: a review.

Cancer is a significant public health problem worldwide, and its morbidity and mortality are challenging to improve, which is an important obstacle to prolonging life expectancy. Cytotoxic drugs have been used in anti-cancer therapy since the 1940s. They play an important role in tumor therapy.

Partial quadrate lobectomy improves early outcomes of laparoscopic Kasai surgery in type III biliary atresia.

Objective: To evaluate the early efficacy and safety of partial quadrate lobectomy during laparoscopic Kasai surgery for type III biliary atresia.

Methods: This retrospective study included 25 children diagnosed with type III biliary atresia, who underwent laparoscopic Kasai surgery between February 2018 and July 2022. Patients were divided into two groups: one with partial quadrate lobectomy and the other without.

WMC-RTDETR: a lightweight tea disease detection model.

Tea pest and disease detection is crucial in tea plantation management, however, challenges such as multi-target occlusion and complex background impact detection accuracy and efficiency. To address these issues, this paper proposes an improved lightweight model, WMC-RTDETR, based on the RT-DETR model. The model significantly enhances the ability to capture multi-scale features by introducing wavelet transform convolution, improving the feature extraction accuracy in complex backgrounds, and increasing detection efficiency while reducing the number of model parameters.

Quercetin Inhibits Gastric Cancer Progression via FAM198B/MAPK Pathway Modulation.

Background: The family with the sequence similarity 198 member B (FAM198B) has been found to contribute to the progression of gastric cancer (GC). However, the role and molecular mechanism of FAM198B in GC remains poorly understood. This work found a link between FAM198B and quercetin, and the regulatory effect of FAM198B on the MAPK pathway of GC.

Targeting PCNA/PARP1 axis inhibits the malignant progression of hepatocellular carcinoma.

Introduction: Proliferating cell nuclear antigen (PCNA) is associated with the proliferation and recurrence of various cancers, and its high expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients. However, the mechanistic role of PCNA in HCC progression remains poorly understood. This study aimed to investigate how PCNA regulates DNA damage repair and cell cycle progression in HCC, with a focus on its interaction with poly (ADP-ribose) polymerase 1 (PARP1) and therapeutic implications.

Laparoscopic appendectomy and cholecystectomy in a 2-year-old with acute suppurative appendicitis and gallbladder torsion: a case report.

Background: Pediatric gallbladder torsion is a rare but potentially life-threatening cause of acute abdomen. The first case was reported in the 19th century, yet the precise pathogenesis remains unclear. Due to its nonspecific symptoms, gallbladder torsion in children is frequently misdiagnosed as more common conditions, such as acute appendicitis, cholecystitis, or gastrointestinal infections.

Multiple data sets to explore the key molecules and mechanism of lymph node metastasis in gastric cancer.

Objective: To explore the key molecules and regulatory mechanisms of lymph node metastasis in gastric cancer.

Methods: The differential genes and key genes of lymph node metastasis in gastric cancer were analyzed by utilizing multiple data sets. The key genes were analyzed by GSEA analysis, transcription factor analysis, nomogram prediction model construction, immune infiltration analysis, GSVA analysis, drug sensitive analysis and single cell data analysis.

Diagnosis of small bowel obstruction due to Shine-Muscat grape ingestion: case report.

Introduction: This case report describes a rare instance of small bowel obstruction (SBO) caused by the ingestion of a whole Shine-Muscat grape in a 7-month-old infant. This case adds to the scientific literature by highlighting the potential risk of common fruits, such as grapes, in causing serious gastrointestinal blockages in pediatric patients, which is an uncommon but important consideration for pediatricians and caregivers.

Main Symptoms And Clinical Findings: A 7-month-old female presented with a 3-day history of vomiting, which progressed to bilious vomiting, accompanied by abdominal distension and dehydration.

Thermal Annealing-Induced Phase Conversion in N-type Triple-Cation Lead-Based Perovskite Field Effect Transistors.

The field of perovskite optoelectronics and electronics has rapidly advanced, driven by excellent material properties and a diverse range of fabrication methods available. Among them, triple-cation perovskites such as CsFAMAPbI offer enhanced stability and superior performance, making them ideal candidates for advanced applications. However, the multicomponent nature of these perovskites introduces complexity, particularly in how their structural, optical, and electrical properties are influenced by thermal annealing─a critical step for achieving high-quality thin films.

The right brachioradial artery with the radial recurrent artery absence: a cadaveric case report.

Purpose: The purpose of this case report is to present an anatomical variation of the radial artery observed in anatomical practice and to discuss its clinical significance.

Methods: During the dissection of the right upper limb of a Chinese adult male, a high-position variation of the right radial artery with the absence of the radial recurrent artery was found.

Results: The variant branch of the right radial artery originates from the brachial artery and arises medially in the upper one-third of the arm.

A necroptosis-regulated model from single-cell analysis that predicts survival and identifies the Pivotal role of MAGEA6 in hepatocellular carcinoma.

Objective: Hepatocellular carcinoma (HCC) ranks as the third leading cause of cancer-related deaths, constituting 75%-85 % of all primary liver cancers. The objective of this study was to develop a necroptosis-related gene signature using single-cell and bulk RNA sequencing to predict HCC patient prognoses.

Methods: A total of 25 key necroptosis regulators were identified from previous literature.

High carrier mobility along the [111] orientation in CuO photoelectrodes.

Solar fuels offer a promising approach to provide sustainable fuels by harnessing sunlight. Following a decade of advancement, CuO photocathodes are capable of delivering a performance comparable to that of photoelectrodes with established photovoltaic materials. However, considerable bulk charge carrier recombination that is poorly understood still limits further advances in performance.

A network of transcriptomic signatures identifies novel comorbidity mechanisms between schizophrenia and somatic disorders.

The clinical burden of mental illness, in particular schizophrenia and bipolar disorder, are driven by frequent chronic courses and increased mortality, as well as the risk for comorbid conditions such as cardiovascular disease and type 2 diabetes. Evidence suggests an overlap of molecular pathways between psychotic disorders and somatic comorbidities. In this study, we developed a computational framework to perform comorbidity modeling via an improved integrative unsupervised machine learning approach based on multi-rank non-negative matrix factorization (mrNMF).

Alpha-fetoprotein upregulates hepatocellular carcinoma cell-intrinsic PD-1 expression through the LATS2/YAP/TEAD1 pathway.

Background: Hepatocellular carcinoma (HCC) cell-intrinsic programmed death 1 (PD-1) promotes tumor progression. However, the mechanisms that regulate its expression are unclear. This study investigated the impact of alpha-fetoprotein (AFP) on HCC cell-intrinsic PD-1 expression.

Fast Near-Infrared Photodetectors Based on Nontoxic and Solution-Processable AgBiS.

Solution-processable near-infrared (NIR) photodetectors are urgently needed for a wide range of next-generation electronics, including sensors, optical communications and bioimaging. However, it is rare to find photodetectors with >300 kHz cut-off frequencies, especially in the NIR region, and many of the emerging inorganic materials explored are comprised of toxic elements, such as lead. Herein, solution-processed AgBiS photodetectors with high cut-off frequencies under both white light (>1 MHz) and NIR (approaching 500 kHz) illumination are developed.