[Attribution Analysis of Vegetation Variation in the Karst Region of Southwest China Considering Time Lag and Accumulation Effects].

Assessing the effects of climate change and human activities on vegetation changes in the karst region of southwest China is of great significance for the sustainable development of karst ecosystems. Based on the GIMMS NDVI and SPOT NDVI fusion data， combined with precipitation and temperature meteorological station data from 1982 to 2019， the effects of climate change and human activities on vegetation changes before and after the ecological restoration projects （ERPs） were investigated by using trend analysis， partial correlation analysis， and modified residual analysis. The results showed that： ① Temporally， the trend of NDVI had shifted from a slow decrease （>0.

Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos.

Histone crotonylation, a conserved post-translational histone modification, plays a crucial role in transcriptional regulation. However, its function in early embryonic development remains largely unexplored. Here, we perform genome-wide mapping of histone crotonylation in mouse and human early embryos.

Melatonin and spermidine protect early mouse embryos from ethylparaben toxicity by restoring histone modifications and subcellular structures.

Ethylparaben (EtP), a widely used preservative in food and cosmetics, has raised increasing concerns in the field of reproductive toxicology due to its potential adverse effects on human health. In this study, we show that EtP exposure induces developmental arrest at the 2-cell stage in mouse embryos. This arrest coincides with elevated reactive oxygen species levels, mitochondrial dysfunction, DNA damage, and apoptosis.

Ecological functions of plant-beneficial microbiomes and their application prospects in sustainable agriculture.

Soil microbial communities form dynamic interaction networks with plants, which influence growth, development, stress tolerance, and ecological adaptability of plants. In recent years, the roles of beneficial micro-biomes, including plant growth-promoting rhizobacteria (PGPR), arbuscular mycorrhizal fungi (AMF), and plant-associated bacteriophages, in agricultural ecosystems have received increasing attention. Beneficial microorganisms can facilitate soil nutrient release, secrete plant hormones, and regulate signaling pathways, thereby establishing symbiotic relationships with plant for healthy host growth.

Shifts in soil prokaryotic community structure due to clear-cutting secondary Acacia mangium forests and replacing with Eucalyptus urophylla.

In recent years, many secondary forests have been converted into artificial tree plantations in China to improve forest quality or increase timber production, which may influence soil microorganisms and nutrient cycling. By sequencing and analyzing microbial 16S rRNA genes in the soils of secondary Acacia mangium forests and 5-year-old and 10-year-old Eucalyptus urophylla plantations that were converted from clear-cutting secondary A. mangium forests in South China, we aimed to evaluate the effects of the forest management of clear-cutting and replacing secondary forests on soil prokaryotic communities.

Mechanistic insights and future perspectives of drought stress management in staple crops.

Due to extended periods of below-normal rainfall and rising temperatures, drought is a significant global issue for agricultural productivity. Hydrological, agricultural, and meteorological droughts all pose different problems with regard to the availability of water for important crops, which in turn impacts plant development and yield. Depending on the crop species and stage of maturity, drought stress degrades plant metabolism and physiological processes, resulting in decreased growth and yield losses that can range from 30% to 90%.

Seminal plasma S100A8/A9 as a potential biomarker of genital tract inflammation.

Infections and inflammatory reactions in the male genital tract are the leading causes of male infertility with a prevalence of 6%-10%, primarily affecting testicular and epididymal function and ultimately compromising sperm quality. However, most infertile patients with genital infection/inflammation are asymptomatic and easily overlooked. Traditional indicators, including white blood cells, elastase, and other components in semen, can reflect inflammation of the genital tract, but there is still a lack of a uniform standard method of detection.

Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice.

Epigenetic modifiers that accumulate in oocytes, play a crucial role in steering the developmental program of cleavage embryos and initiating life. However, the identification of key maternal epigenetic regulators remains elusive. In the findings, the essential role of maternal Ep400, a chaperone for H3.

Reforestation of changes the relative abundances of important prokaryotic families in soil.

Over the past decades, many forests have been converted to monoculture plantations, which might affect the soil microbial communities that are responsible for governing the soil biogeochemical processes. Understanding how reforestation efforts alter soil prokaryotic microbial communities will therefore inform forest management. In this study, the prokaryotic communities were comparatively investigated in a secondary Chinese fir forest (original) and a reforested Chinese fir plantation (reforested from a secondary Chinese fir forest) in Southern China.

Intravenous immunoglobulin for treatment of hospitalized COVID-19 patients: an evidence mapping and meta-analysis.

Background: The clinical efficacy and safety of intravenous immunoglobulin (IVIg) treatment for COVID-19 remain controversial. This study aimed to map the current status and gaps of available evidence, and conduct a meta-analysis to further investigate the benefit of IVIg in COVID-19 patients.

Methods: Electronic databases were searched for systematic reviews/meta-analyses (SR/MAs), primary studies with control groups, reporting on the use of IVIg in patients with COVID-19.

Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model.

Hyperproteinemia is a metabolic disorder characterized by abnormally elevated plasma protein concentrations (PPC) in humans and animals. Here, a genetic silkworm model with high PPC was employed to investigate the effect of elevated PPC on female reproduction. Transcriptomic analysis revealed that high PPC induces downregulation of the ovarian development-related genes and disrupts ovarian sugar metabolism.

Comparison analysis of full-spectrum metabolomics revealed on the variation of potential metabolites of unscented, scented, and Lour. scented black teas.

Introduction: In recent years, scented black tea has attracted much attention due to its pleasant floral aroma and mellow flavor, but little research has been carried out on its flavor metabolic profile.

Methods: In this study, the flavor metabolic profiles of unscented, scented, and Lour. scented black teas were investigated using full-spectrum metabolomics analysis method, the first time that the flavor profiles of scented black tea were characterized in detail.

Comprehensive analysis of prognostic value and immunotherapy prospect of brain cytoplasmic RNA1 in hepatocellular carcinoma.

Background: The expression of brain cytoplasmic RNA1 () is linked to the clinicopathology and prognosis of several types of cancers, among which hepatocellular carcinoma (HCC) is one of the most frequent types of cancer worldwide.

Aim: To explore the prognostic value and immunotherapeutic potential of in HCC by bioinformatics and meta-analysis.

Methods: Information was obtained from the Cancer Genome Atlas database.

Impact of fermented Broussonetia papyrifera on laying performance, egg quality, lipid metabolism, and follicular development of laying hens.

Hybrid Broussonetia papyrifera (BP) has been widely planted and commonly used as ruminant forage source after fermentation in China. Very less information is available to know the impact of fermented BP on laying hens, thus, we have investigated effects of dietary supplementation of Lactobacillus plantarum-fermented B. papyrifera (LfBP) on laying performance, egg quality, serum biochemical parameters, lipid metabolism, and follicular development of laying hens.

Dynamic changes and correlation between symptoms and quality of life in patients with breast cancer during chemotherapy.

Background: Standardized chemotherapy for breast cancer can improve the survival of patients, but during the process, it is accompanied by a variety of symptoms.

Objective: To explore the dynamic changes of symptoms and quality of life in breast cancer patients at different time points during chemotherapy, and to explore the correlation with quality of life.

Method: A prospective study method was used to collect 120 breast cancer patients undergoing chemotherapy as the research objects.

Sub-satisfactory recanalization of severe middle cerebral artery stenoses can significantly improve hemodynamics.

Purpose: To investigate the effect of sub-satisfactory stent recanalization on hemodynamic stresses for severe stenoses of the middle cerebral artery (MCA) M 1 segment.

Materials And Methods: Patients with severe stenoses of the MCA M1 segment treated with endovascular stent angioplasty were retrospectively enrolled. Three-dimensional digital subtraction angiography before and after stenting was performed; the computational fluid dynamics (CFD) analysis of hemodynamic stresses at the stenosis and normal segments proximal and distal to the stenoses was analyzed.

Mechanism of hyperproteinemia-induced blood cell homeostasis imbalance in an animal model.

Hyperproteinemia is a metabolic disorder associated with increased plasma protein concentration (PPC) and is often clinically complicated by malignant diseases or severe infections. At present, however, research on the molecular mechanism underlying high PPC (HPPC) is scant. Here, an animal model of primary hyperproteinemia was constructed in an invertebrate ( ) to investigate the effects of HPPC on circulating blood cells.

Differentiation of histopathological growth patterns of colorectal liver metastases by MRI features.

Background: It is necessary to develop an accurate non-invasive method to determine the histopathological growth pattern (HGP) of colorectal liver metastasis (CRLM) before surgery. The present study aimed to identify various HGPs of CRLM by magnetic resonance imaging (MRI) features.

Methods: This retrospective study included 53 chemo-naïve patients with CRLM between December 2013 and September 2019.

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model.

BACKGROUND The aim of the present study was to investigate the potential anticonvulsant effect of methylene blue (MB) in a kainic acid (KA)-induced status epilepticus (SE) model. The effects of MB on levels of oxidative stress and glutamate (Glu) also were explored. MATERIAL AND METHODS Sixty C57BL/6 mice were randomly divided into 5 equal-sized groups: (1) controls; (2) KA; (3) MB 0.

Case Report: Double Micro-Guidewire Technique for Emergent Rescue of Proximal Stent Collapse During Recanalization of Nonacute Occlusion of Vertebral Artery.

Cerebral arteries are usually tortuous, and in the treatment of cerebrovascular diseases with stenting, a stent deployed may be collapsed at one end, leading to reduced blood flow and subsequent stent occlusion. Immediate rescuing measures should be implemented to prevent severe ischemic events. In this case report, we present a case with V4 segment occlusion of the right vertebral artery treated with endovascular stent angioplasty.

Chromium accumulation in soil, water and forage samples in automobile emission area.

Environmental contamination caused by various pollutants due to automobile emissions is an alarming issue. One important type of the pollutants are heavy metals, including chromium (Cr) added by the exhaust of toxic smoke of vehicles. These pollutants are added to forage crops cultivated near roadsides, soil and irrigation water.

Factors affecting in-stent restenosis after angioplasty with the Enterprise stent for intracranial atherosclerotic diseases.

This study investigated factors affecting the safety and in-stent restenosis after intracranial stent angioplasty using the Enterprise stent for symptomatic intracranial atherosclerotic stenosis. Between January 2017 and March 2019, patients with intracranial atherosclerotic stenosis treated with Enterprise stent angioplasty were enrolled, including 400 patients in the modeling group and 89 patients in the validation group. The clinical factors affecting in-stent restenosis after Enterprise stent angioplasty in the modeling group were analyzed, and a logistic regression model of these factors was established and validated in the validation group.

Efficiency of different types of biochars to mitigate Cd stress and growth of sunflower (; L.) in wastewater irrigated agricultural soil.

Cadmium contamination in croplands is recognized one of the major threat, seriously affecting soil health and sustainable agriculture around the globe. Cd mobility in wastewater irrigated soils can be curtailed through eco-friendly and cost effective organic soil amendments (biochars) that eventually minimizes its translocation from soil to plant. This study explored the possible effects of various types of plants straw biochar as soil amendments on cadmium (Cd) phytoavailability in wastewater degraded soil and its subsequent accumulation in sunflower tissues.