Gold clusters assembled homochiral helical microbowties.

Construction of artificial microscale helical superstructures holds great significance for understanding hierarchical evolution of chiral architectures in nature. However, fabricating microscale helical superstructures from metal clusters remains mysterious and challenging. Here, we achieved hierarchically assembled helical bowties with micrometer scale via electrostatic interaction-driven co-assembly of chiral Au clusters and -1,4-cyclohexanediamine.

Expression of ApoE and Spp1 in the cochlea and auditory cortex of age-related hearing loss mice.

Objective: Screen for differential proteins in the cochlea of mice associated with Age-Related Hearing Loss (ARHL), analyze and validate the expression of specific differential proteins and genes in the cochlea and auditory cortex of ARHL mice, and preliminarily explore their potential mechanisms of action.

Methods: ABR (Auditory Brainstem Response) hearing tests were conducted to select 15-month-old C57BL/6 mice with significantly decreased hearing as the experimental group and 2-month-old mice with normal hearing as the control group. Cochleae were dissected, and unlabeled quantitative proteomics was employed to identify and analyze differentially expressed proteins in the inner ear of the two groups of mice.

PJ34 prevents cisplatin-induced hair cell loss via inhibition of PARP-1-AIF parthanatos.

The poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor PJ34 acts as an anti-inflammatory and neuroprotective agent by modulating parthanatos. This study aimed to explore the protective effects of PJ34 against cisplatin-induced injury in auditory cells and to elucidate its underlying mechanism of action. Flow cytometry and immunofluorescence were employed to detect apoptosis in HEI-OC1 and ovarian cancer cell lines.

High-grade corded and hyalinized endometrioid carcinoma with high microsatellite instability and STK11 mutation: A case report and literature review.

Corded and hyalinized endometrioid carcinoma (CHEC) is a rare morphological variant of EC, characterized by biphasic histological characteristics. CHEC are predominantly low-grade, while high-grade CHEC is exceedingly rare in clinical practice. The present study reports a case of CHEC with a high-grade component in a 38-year-old female patient.

Extracellular Vesicles as Diagnostic Metrics for Cardiovascular Disease: Where We are and How to Achieve in Clinics.

As one of the leading causes of death globally, early diagnosis and prevention of cardiovascular disease have become the focus of clinical and public health. Extracellular vesicles (EVs) are small, double-layered membrane structures actively secreted by cells and are widely present in body fluids such as blood, urine, and saliva. They carry various bioactive molecules, including proteins and nucleic acids, and are known for their remarkable stability and easy accessibility, making them promising candidates for identifying cardiovascular disease.

In-Situ Surface Repair of FAPbBr Quantum Dots toward High-Performance Pure-Green Perovskite Light-Emitting Diodes.

Metal halide perovskite light-emitting diodes (PeLEDs) are ideal for high-resolution displays due to their tunable emission, narrow spectra, and low-cost processing. Colloidal FAPbBr perovskite quantum dots (PeQDs) enhance radiative recombination, making them efficient for pure-green PeLEDs. However, their low stability and surface defects limit their practical application.

Cardiovascular mortality risk in patients with ovarian cancer: a population-based study.

Objectives: Ovarian cancer (OC) can occur at different ages and is affected by a variety of factors. In order to evaluate the risk of cardiovascular mortality in patients with ovarian cancer, we included influencing factors including age, histological type, surgical method, chemotherapy, whether distant metastasis, race and developed a nomogram to evaluate the ability to predict occurrence. At present, we have not found any correlation studies on cardiovascular death events in patients with ovarian cancer.

Fluorescent TPE Macrocycle Relayed Light-Harvesting System for Bright Customized-Color Circularly Polarized Luminescence.

Artificial systems for sequential chirality transmission/amplification and energy relay are perpetual topics that entail learning from nature. However, engineering chiral light-harvesting supramolecular systems remains a challenge. Here, we developed new chiral light-harvesting systems with a sequential Förster resonance energy transfer process where a designed blue-violet-emitting BINOL (1,1'-Bi-2-naphthol) compound, BINOL-di-octadecylamide (BDA), functions as an initiator of chirality and light absorbance, a new green-emitting hexagonal tetraphenylethene-based macrocycle (TPEM) with aggregation-induced emission serves as a conveyor, and Nile red (NiR) or/and a near-infrared dye, tetraphenylethene (TPE)-based benzoselenodiazole (TPESe), are the terminal acceptors.

Author Correction: Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Enhanced DNA Sensing and Chiroptical Performance by Restriction of Double-Bond Rotation of AIE -Tetraphenylethylene Macrocycle Diammoniums.

The aggregation-induced emission (AIE) mechanism of restriction of double-bond rotation (RDBR) was utilized to design an excellent solid emitter and sensor for the first time. Thus, -tetraphenylethylene (TPE) macrocycle diammoniums were synthesized and bound to a DNA chain by its two ammonium arms. The formed TPE dicycle at the position restricted the rotation of the double bond in both the ground and excited states, resulting in AIE enhancement, chiroptical performance enhancement, and sensing enhancement.

Chiral recognition and enantiomer excess determination based on emission wavelength change of AIEgen rotor.

Chiral recognition, such as enantioselective interactions of enzyme with chiral agents, is one of the most important issues in the natural world. But artificial chiral receptors are much less efficient than natural ones. For tackling the chiral recognition and enantiomer excess (ee) analysis, up until now all the fluorescent receptors have been developed based on fluorescence intensity changes.

New Acylhydrazone Photoswitches with Quantitative Conversion and High Quantum Yield but without Hydrogen Bond Stabilizing ( Z)-Isomer.

Hydrazones are recently attracting increasing interest because of their facile synthesis and high addressability, fatigue resistance, and modifiability as molecular switches. However, this new class of switches generally suffers from low conversion from E- to Z-configuration. Here, novel benzoylhydrazones were synthesized by condensation of 2-methoxynaphthaldhyde and benzoylhydrazine.

Selective Fluorescence Turn-On Sensing of Phosphate Anion in Water by Tetraphenylethylene Dimethylformamidine.

A tetraphenylethylene (TPE) derivative bearing two dimethylformamidine units was synthesized. The dihydrogen chloride salt of this TPE derivative was soluble in water and showed almost no emission. By addition of phosphate anions, the dihydrogen chloride salt could be transformed into the monohydrogen chloride salt, which was barely soluble and emitted strong fluorescence through aggregation-induced emission (AIE), while many other anions could not bring about a fluorescence enhancement.

Macrocycles and cages based on tetraphenylethylene with aggregation-induced emission effect.

Organic molecules with an aggregation-induced emission (AIE) effect have recently been attracting more and more attention due to their colossal potential in solid emitters and chemo/biosensors. The number and variety of AIEgen compounds are expanding very rapidly to obtain better application performance and a wider area of application. Among AIEgen systems, tetraphenylethylene (TPE) and its derivatives are the class that have received the most extensive study and the most rapid development because of their facile synthesis.

GnT-V promotes chemosensitivity to gemcitabine in bladder cancer cells through β1,6 GlcNAc branch modification of human equilibrative nucleoside transporter 1.

Human equilibrative nucleoside transporter 1 (hENT1) transports nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-tumor drugs. Gemcitabine is a frontline agent of chemotherapy for bladder cancer despite its limited efficacy due to chemoresistance, there is an acute need to decipher mechanisms underlying chemosensitivity to gemcitabinein in bladder cancer cells. Here we report a novel role for N-acetylglucosaminyltransferase V (GnT-V) in gemcitabine chemosensitivity.

Evidence for Aggregation-Induced Emission from Free Rotation Restriction of Double Bond at Excited State.

This paper reports that cis-TPE dicycles emit strong fluorescence, while the gem dicycles show almost no emission in solution, demonstrating that the free rotation restriction of the double bond at the excited state is the key factor for AIE effects.

Supramolecular Polymers Based on Non-Coplanar AAA-DDD Hydrogen-Bonded Complexes.

Non-coplanar triple-hydrogen-bond arrays are connected as telechelic groups to alkyl chains and their properties as AA/BB type supramolecular polymers are examined. Viscosity studies at three temperatures are used to study the ring-chain equilibrium and determine the critical concentrations where polymer chains are formed. It is observed that neither the temperature range studied nor the alkyl chain length of one component significantly affect the polymerization properties in this system.

Porous Hydrogen-Bonded Organic Frameworks.

Ordered porous solid-state architectures constructed via non-covalent supramolecular self-assembly have attracted increasing interest due to their unique advantages and potential applications. Porous metal-coordination organic frameworks (MOFs) are generated by the assembly of metal coordination centers and organic linkers. Compared to MOFs, porous hydrogen-bonded organic frameworks (HOFs) are readily purified and recovered via simple recrystallization.

An AAA-DDD triply hydrogen-bonded complex easily accessible for supramolecular polymers.

For a complementary hydrogen-bonded complex, when every hydrogen-bond acceptor is on one side and every hydrogen-bond donor is on the other, all secondary interactions are attractive and the complex is highly stable. AAA-DDD (A=acceptor, D=donor) is considered to be the most stable among triply hydrogen-bonded sequences. The easily synthesized and further derivatized AAA-DDD system is very desirable for hydrogen-bonded functional materials.