Lipoprotein combine index is associated with non-alcoholic fatty liver disease: a 5-year longitudinal cohort study in non-obese Chinese populations with normal lipids.

Objective: Current evidence concerning the association between lipoprotein combine index (LCI) and Non-alcoholic fatty liver disease (NAFLD) in non-obese people remains limited. This 5-year longitudinal cohort study aimed to explore the connection between LCI and risk of NAFLD in non-obese Chinese individuals with normal lipids.

Methods: This retrospective cohort study from January 2010 to December 2014 consecutively and non-selectively collected 9,838 non-obese participants with normal lipid profiles in a Chinese hospital.

Association between serum albumin to creatinine ratio and non-alcoholic fatty liver disease: a longitudinal cohort study in non-obese Chinese individuals.

Objective: There is limited research on the association between serum albumin to creatinine ratio (sACR) and non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the association between sACR and NAFLD risk in non-obese Chinese individuals.

Methods: This longitudinal cohort study comprised 14,698 non-obese individuals with normal LDL-c levels followed from January 2010 to December 2014.

Dual-signal multiplex assays based on non-tandem enzymes for simultaneous detection of multiple pathogenic bacteria.

Enzymatic assays represent a promising alternative to conventional multiplex optical methods for multi-target detection due to their exceptional specificity and catalytic versatility. Nevertheless, most existing enzymatic systems are limited to single-target detection. In this work, we developed a dual-signal multiplex assay based on non-tandem enzymes for the simultaneous detection of multiple pathogenic bacteria.

Machine learning differentiation of rheumatoid arthritis-Sjögren's syndrome overlap from Sjögren's syndrome with polyarthritis.

Objective: This study aimed to evaluate the utility of machine learning algorithms in differentiating rheumatoid arthritis-Sjögren's syndrome overlap (RA-SS) from Sjögren's syndrome with polyarthritis (SS-PA), and to identify key factors influencing diagnostic differentiation.

Methods: This retrospective analysis included 106 RA-SS and 135 SS-PA patients randomized 7:3 into training and validation sets. Clinical, laboratory, and radiographic data were collected.

Significant reduction in manual annotation costs in ultrasound medical image database construction through step by step artificial intelligence pre-annotation.

This study investigates the feasibility of reducing manual image annotation costs in medical image database construction by utilizing a step by step approach where the Artificial Intelligence model (AI model) trained on a previous batch of data automatically pre-annotates the next batch of image data, taking ultrasound image of thyroid nodule annotation as an example. The study used YOLOv8 as the AI model. During the AI model training, in addition to conventional image augmentation techniques, augmentation methods specifically tailored for ultrasound images were employed to balance the quantity differences between thyroid nodule classes and enhance model training effectiveness.

The Influence of Contextual Social Deprivation on Poor Health Among Urban Male Residents: A Nationally Respresentative Study in China.

This study aimed to examine whether contextual social deprivation is independently associated with health outcomes. A cross-sectional, multistage sampling design was employed to interview participants from six selected cities in China. A standardized questionnaire was used to collect data on individual socioeconomic characteristics and contextual social deprivation.

Impact of diagnosis-intervention packet payment on the consistency of hospitalization expenses across different medical insurance schemes in China.

Background: The Diagnosis-Intervention Packet Payment (DIP) system is regarded as a localized cost-control strategy in China. It aims to improve healthcare efficiency, curb the growth of medical expenses, and optimize the allocation of medical resources among diverse groups.

Objective: This study aims to assess the impact of DIP payment reforms on differential changes in patients' hospitalization expense and to explore the degree of concentration of hospitalization expense for patients with different insurance schemes undergoing treatment for typical diseases, with a view to providing policy recommendations for improving the medical insurance system.

[Preparation and physicochemical properties of nano-silver acupuncture needles].

Objective: To explore the preparation of nano-silver acupuncture needles and evaluate the appearance, structure and properties.

Methods: Stainless steel acupuncture needles were pretreated by polishing with sandpaper and cleaning with ultrapure water and absolute ethanol. As the working electrodes, the needles were placed in an electrolyte solution contained silver nitrate (AgNO), potassium nitrate (KNO), and polyvinylpyrrolidone (PVP); and the silver nanoparticles were deposited at a constant voltage of -0.

A two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers.

Previous observational studies have suggested a potential link between Type 1 Diabetes (T1D) and site-specific cancer risk. However, the nature of this association remains uncertain due to confounding factors, reverse causation, and biases inherent in observational research. To address this gap, we conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between T1D and 22 site-specific cancers.

Research Progress in Copper Homeostasis and Diseases.

As an indispensable trace element in the human body,copper plays an important role in various physiological and biochemical reactions.The dyshomeostasis of copper leads to the disorder of copper metabolism and the occurrence of related diseases.Cuproptosis,a newly proposed regulatory cell death mode,is different from the known apoptosis,pyroptosis,necroptosis,and ferroptosis.

Deciphering molecular crosstalk mechanisms between skeletal muscle atrophy and KRAS-mutant pancreatic cancer: a literature review.

Background And Objective: Cachexia-induced skeletal muscle atrophy is a critical manifestation in Kirsten rat sarcoma viral oncogene homologue (KRAS)-mutant pancreatic cancer (PC) patients, predominantly characterized by a shift in metabolic equilibrium towards catabolism that accelerates protein degradation in myofibers and leads to muscle atrophy. This metabolic reprogramming not only supports tumor growth but also precipitates energy depletion in skeletal muscle tissues. Exploring these mechanisms reveals potential therapeutic targets in the metabolic and proteolytic pathways associated with KRAS-mutant PC.

Preventive and Therapeutic effects of Metformin in Cancer: A Meta-Analysis of RCT and Cohort Studies.

Background: There is discrepancy of results among various individual and me-ta-analytical studies about the effect of metformin on cancer risk and patients' survival. Therefore, we have conducted a comprehensive, updated meta-analysis to evaluate the preventive and therapeutic effects of metformin for cancer patients, as well as the inci-dence of adverse reactions, among metformin users.

Methods: A total of 18 studies (10 cohort studies and 8 randomized controlled trials) in-volving 1,300,820 participants from Europe, North America, and Asia were included in this meta-analysis.

[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].

As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.

[Fatty acid content in Jiangnan dishes in Hangzhou].

Objective: To analyze the fatty acid content of Jiangnan dishes in Hangzhou.

Methods: Based on the order frequency records from an online platform, two popular Jiangnan cuisine restaurants were selected for monitoring. Fat extraction was performed on three types of dishes: purely vegetarian, mixed vegetarian and non-vegetarian, and purely non-vegetarian, using acid hydrolysis.

FXR-regulated COX6A2 triggers mitochondrial apoptosis of pancreatic β-cell in type 2 diabetes.

Pancreatic β-cell apoptosis plays a crucial role in the development of type 2 diabetes. Cytochrome c oxidase subunit 6A2 (COX6A2) and Farnesoid X Receptor (FXR) have been identified in pancreatic β-cells, however, whether they are involved in β-cell apoptosis is unclear. Here, we sought to investigate the role of FXR-regulated COX6A2 in diabetic β-cell apoptosis.

Mechanism of intestinal flora affecting SLC2A9 transport function to promote the formation of hyperuricemia.

Objective: To investigate the structural characteristics of the intestinal flora in obese-hyperuricemic (HUA-W) patients and the mechanisms by which they promote the formation of hyperuricemia.

Methods: 120 human fecal samples (60 cases in HC, 30 cases in HUA-N, and 30 cases in HUA-W) and 40 cases in the colonic tissues (20 cases in HC, 10 cases in HUA-N, and 10 cases in HUA-W) were collected. The intestinal flora of faeces was detected by 16s rRNA method; and the expression of SLC2A9 on human colon tissues was detected by RT-qPCR method and immunofluorescence method.

Device for automated aseptic sampling: Automated sampling solution for future cell and gene manufacturing.

Cell sampling is a key step performed regularly throughout the cell manufacturing process to gather cell samples for cell growth, progress, and characteristics analysis. While the current method of sampling by pipetting in a biosafety cabinet is commonly used, it is labour-intensive and susceptible to contamination risks. We have developed Device for Automated Aseptic Sampling (DAAS), to enable automated, small volume (0.

Increased COX6A2 Promotes Pancreatic β-Cell Apoptosis and Is Suppressed in Diabetic GK Rats After Roux-en-Y Gastric Bypass.

Cytochrome c oxidase subunit 6A2 (COX6A2) expression is increased in diabetic islets. Increased COX6A2 promotes β-cell apoptosis via modulation of cyclophilin D-mediated cytochrome c release from mitochondria to the cytoplasm. Carbohydrate-responsive element-binding protein epigenetically regulates COX6A2 expression in β-cells.

Acupuncture Provides Short-Term Functional Improvements and Pain Relief for Patients After Knee Replacement Surgery: A Systematic Review and Meta-analysis.

The impact of acupuncture on knee function and pain intensity following knee replacement remains controversial. Therefore, we categorized the postsurgery recovery period into 3 phases: short-term (≤2 weeks), intermediate-term (2 weeks-3 months), and long-term (>3 months), and then assessed the effectiveness of acupuncture in improving function and alleviating pain at different stages following knee replacement. This meta-analysis included randomized controlled trials that compared acupuncture intervention with either no treatment or a sham group after knee replacement.

Regulation of Nrf2/A20/eEF1A2 Axis by Ginsenoside Rb1: A Key Pathway in Alleviating Cerebral Ischemia-Reperfusion Injury.

Background: Cerebral ischemia-reperfusion injury (CIRI) is a prevalent neurological disorder, characterized by the oxidative stress and inflammatory response induced during the ischemia-reperfusion process, leading to significant damage to brain cells. Ginsenoside Rb1, a natural medicinal ingredient, possesses potential neuroprotective effects. This study aims to investigate the mechanism of action of ginsenoside Rb1 in CIRI and its protective effects on brain injury.

CCL2 promotes EGFR-TKIs resistance in non-small cell lung cancer via the AKT-EMT pathway.

Acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) represents a primary cause of treatment failure in non-small cell lung cancer (NSCLC) patients. Chemokine (C-C motif) ligand 2 (CCL2) is recently found to play a pivotal role in determining anti-cancer treatment response. However, the role and mechanism of CCL2 in the development of EGFR-TKIs resistance have not been fully elucidated.