Exploring the dual effects of pet ownership on mental health outcomes in Chinese patients with chronic diseases: A population-based study.

Background: Mental health is more vulnerable among chronic disease patients. However, the relationship between pet ownership and their psychological well-being remains uncertain in China.

Methods: Using multi-stage stratified sampling, 8986 patients with chronic disease were surveyed from July to September 2024.

SpaSEG: unsupervised deep learning for multi-task analysis of spatially resolved transcriptomics.

Spatially resolved transcriptomics (SRT) for characterizing spatial cellular heterogeneities in tissue environments requires systematic analytical approaches to elucidate gene expression variations within their physiological context. Here, we introduce SpaSEG, an unsupervised deep learning model utilizing convolutional neural networks for multiple SRT analysis tasks. Extensive evaluations across diverse SRT datasets generated by various platforms demonstrate SpaSEG's superior robustness and efficiency compared to existing methods.

The effect of follow-up on the blood pressure control: a longitudinal study in rural areas of China.

Background: High health risk and low management compliance pose significant challenges in controlling hypertensive patients' blood pressure. Therefore, this study aims to investigate the impact of follow-up services on blood pressure control at the primary level.

Methods: A total of 871 hypertensive patients consecutively enrolled from 2016 to 2021 were randomly selected from Qianjiang County, Hubei Province and Changsha County, Hunan Province of China.

Revealing Performance-Limiting Buried Interfaces in Layered Dion-Jacobson Lead-Iodide Perovskites.

Dion-Jacobson (DJ) two-dimensional (2D) perovskites have emerged as promising photovoltaic materials due to their superior structural and chemical stability compared to three-dimensional (3D) perovskites. However, their optoelectronic performance remains limited by imperfections at interfaces and a fundamental understanding of these interfacial properties is missing. Herein, we present interfacial structure-property relationships in DJ perovskites by directly probing buried interfaces using combined spectroscopic and microscopic characterization techniques.

Degradation Pathway Tailoring through Nanocrystal Interface Engineering for Photostable Perovskite Solar Cells.

While organic-inorganic hybrid perovskites (ABX) hold immense photovoltaic potential, operational instability originating from defect-mediated ion migration and light-induced degradation remains a critical bottleneck. Here, we adopt CsPbICl nanocrystals (CPIC-NCs) and CsPbCl nanocrystals (CPC-NCs) to modify the interface of the perovskite light-absorbing layer. Beyond conventional defect-healing roles (Cs/halide filling of the A/X-site vacancies), this modification can fundamentally alter the degradation pathways of perovskite films under light exposure.

Effects of circPICALM-miR-132-PHKB regulated by METTL3 on proliferation of porcine skeletal muscle satellite cells.

Circular RNA (circRNA) is ubiquitously expressed in highly differentiated eukaryotes, playing an extremely vital regulatory role in muscle growth and development. In this study, we identified circPICALM, a novel circRNA which consists of exons 5 to 9 of the PICALM gene, exhibiting differential expression in the longissimus dorsi muscle (LD) of adult (QA) and newborn (QN) Queshan Black pigs. CircPICALM is resistant to RNase R, mainly located in the cytoplasm with potential coding capacities.

The longitudinal relationship between night-time sleep duration, midday napping, and frailty among middle-aged and older people in China: a prospective analysis.

Background: Frailty is an important issue presented by ageing. Night-time sleep and midday napping are important modifiable factors influencing health, but their impacts on frailty remain unclear.

Methods: We used five waves of data from the China Health and Retirement Longitudinal Study (2011-20), with 15 333 participants in the baseline sample.

Effect of H2O and CO2 on CO oxidation over Pt/SSZ-13 with active sites regulated by Lewis acidity.

Strategies for controlling the size of metal species using zeolites and their catalytic behavior in industrially relevant processes have attracted widespread attention, but the effect of H2O and CO2 on the catalytic performance of zeolite-based metal catalysts remains obscure. This study investigated the influence of H2O and CO2 on CO oxidation over zeolite-based metal catalysts, along with the precise control of active sites through the regulation of Lewis acidity. It was found that the presence of H2O enhanced CO oxidation and alleviated the inhibitory effect of CO2.

Hydrothermal pretreatment for enhanced thermochemical or biochemical conversion of pharmaceutical biowastes into fuels, fertilizers, and carbon materials.

Pharmaceutical biowastes, rich in organic matter and high in moisture, are typical light industry byproducts with waste and renewable attributes. Thermochemical and biochemical conversion technologies transform these residues into value-added bioproducts, including biofuels, biofertilizers, and bio-carbon materials. Hydrothermal pretreatment effectively removes toxic substances and enhances feedstock for these processes.

Phase transition induced hydrogen activation for enhanced furfural reductive amination over a CoCu bimetallic catalyst.

The synthesis of primary amines from renewable biomass and its derivatives through reductive amination has garnered significant attention. How to construct efficient non-noble-metal catalysts that enable low-temperature catalysis still remains challenging. Herein, we report a Cu-doped Co@CoO heterostructure catalyst that features structural Co-CoCuO bifunctional sites, which enable room temperature reductive amination of various aldehydes with 1.

Impact of primary care and public health integration of chronic conditions in China: a protocol for a prospective multicentre cohort study.

Introduction: The prevalence of chronic conditions is increasing. Given that the majority of chronic patients are managed by primary healthcare providers, there is a need to integrate primary care with public health to address the prevailing situation and enhance patient outcomes. The purpose of this study is to establish, implement and evaluate an integrated primary care and public health model in China for patients with chronic conditions.

Differential chromatin accessibility and Gene Expression Associated with Backfat Deposition in pigs.

Background: Backfat serves as a vital fat reservoir in pigs, and its excessive accumulation will adversely impact pig growth performance, farming efficiency, and pork quality. The aim of this research is to integrate assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and RNA sequencing (RNA-seq) to explore the molecular mechanisms underlying porcine backfat deposition.

Results: ATAC-seq analysis identified 568 genes originating from 698 regions exhibiting differential accessibility, which were significantly enriched in pathways pertinent to adipocyte differentiation and lipid metabolism.

Pathophysiological dynamics in the contact, coagulation, and complement systems during sepsis: Potential targets for nafamostat mesilate.

Sepsis is a life-threatening syndrome resulting from a dysregulated host response to infection. It is the primary cause of death in the intensive care unit, posing a substantial challenge to human health and medical resource allocation. The pathogenesis and pathophysiology of sepsis are complex.

INDELpred: Improving the prediction and interpretation of indel pathogenicity within the clinical genome.

Small insertions and deletions (indels) are critical yet challenging genetic variations with significant clinical implications. However, the identification of pathogenic indels from neutral variants in clinical contexts remains an understudied problem. Here, we developed INDELpred, a machine-learning-based predictive model for discerning pathogenic from benign indels.

Nutritional status and nutritional intervention of older inpatients in China.

Background: Malnutrition is a critical issue among older inpatients, yet limited large-scale research related to this issue has been conducted in China. This study aimed to examine the nutritional status and support of older inpatients in China, assess the associations between disease categories and malnutrition on admission, and explore effective nutritional intervention.

Methods: A total of 24,139 older participants from the China Nutrition Fundamental Data 2020 Project were included.

Proteomic analysis of boar sperm with differential ability of liquid preservation at 17 °C.

Understanding the liquid preservation ability of boar sperm is pivotal for efficient management and breeding of livestock. Although sperm proteins play an important role in semen quality and freezability, how the levels of protein change in boar sperm with different liquid preservation abilities at 17 °C remains unclear. In this study, two groups of boar sperm with extreme difference in liquid preservation ability, namely the good preservation ability (GPA) and the poor preservation ability (PPA) groups, were selected by evaluating sperm motility parameters on the 7th day of liquid preservation at 17 °C.

Seminal plasma metabolomics analysis of differences in liquid preservation ability of boar sperm.

The preservation of semen is pivotal in animal reproduction to ensure successful fertilization and genetic improvement of livestock and poultry. However, investigating the underlying causes of differences in sperm liquid preservation ability and identifying relevant biomarkers remains a challenge. This study utilized liquid chromatography-mass spectrometry (LC-MS) to analyze the metabolite composition of seminal plasma (SP) from two groups with extreme differences in sperm liquid preservation ability.

Genome-Wide Analysis of MAMSTR Transcription Factor-Binding Sites via ChIP-Seq in Porcine Skeletal Muscle Fibroblasts.

Myocyte enhancer factor-2-activating motif and SAP domain-containing transcriptional regulator () regulates its downstream through binding in its promoter regions. However, its molecular mechanism, particularly the DNA-binding sites, and coregulatory genes are quite unexplored. Therefore, to identify the genome-wide binding sites of the transcription factors and their coregulatory genes, chromatin immunoprecipitation sequencing was carried out.

Effects of diet and gender on the pharmacokinetics of oral lenvatinib: A clinical trial in healthy Chinese participants.

Objective: Lenvatinib is a tyrosine kinase inhibitor that helps prevent angiogenesis. In this study, we investigated the potential influencing factors on lenvatinib pharmacokinetics to provide a reference for clinical application.

Materials And Methods: All healthy participants received a single dose of 4 mg lenvatinib mesylate capsules with a high-fat meal or fasted conditions.

Expression Profile and Regulatory Properties of m6A-Modified circRNAs in the Longissimus Dorsi of Queshan Black and Large White Pigs.

It is well known that N6-methyladenosine (m6A) is the most abundant modification in linear RNA molecules, but many circRNA molecules have now been found to have a wide range of m6A modification sites as well. However, there are few relevant studies and information on the expression profile and functional regulatory properties of m6A-modified circRNAs (m6A-circRNAs) in longissimus dorsi. In this study, a total of 12 putative m6A-circRNAs were identified and characterized in the longissimus dorsi of Queshan Black and Large White pigs-8 of them were significantly more expressed in the longissimus dorsi of Queshan Black than in Large White pigs, while the other 4 were the opposite.

Effect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics.

As one of the important traits in pig production, meat quality has important research significance and value. Intramuscular fat (IMF) content is one of the most important factors affecting pork quality. Many experimental studies have shown that IMF content is closely related to the flavor, tenderness, and juiciness of pork.

Transcriptome-wide analysis of RNA mA methylation regulation of muscle development in Queshan Black pigs.

Background: N-methyladenosine (mA) refers to the methylation modification of N position of RNA adenine, a dynamic reversible RNA epigenetic modification that plays an important regulatory role in a variety of life processes. In this study, we used MeRIP-Seq and RNA-Seq of the longissimus dorsi (LD) muscle of adult (QA) and newborn (QN) Queshan Black pigs to screen key genes with mA modification involved in muscle growth by bioinformatics analysis.

Results: A total of 23,445 and 25,465 mA peaks were found in the whole genomes of QA and QN, respectively.