Preoperative nutritional status as a predictor of postoperative overall survival in abdominal tumor surgery: a systematic review and meta-analysis.

Background: Abdominal tumors, including those in the stomach, colon, pancreas, and gallbladder, significantly impact global morbidity and mortality. Surgical resection is the primary treatment, but postoperative outcomes and long-term survival are often affected by factors such as preoperative nutritional status. Malnutrition is common in these patients, making its management crucial for improving outcomes.

The key enzyme PYCR1 in proline metabolism: a dual driver of cancer progression and fibrotic remodeling.

Pyrroline-5-Carboxylate Reductase 1 (PYCR1), a member of the PYCR family, is a key enzyme in the proline biosynthesis pathway. Notably, PYCR1 was originally identified via genetic disease research, linking its mutations to the occurrence of cutis laxa. PYCR1 contributes to the pathogenesis of malignancies and fibrotic diseases via mechanisms involving metabolic reprogramming, Extracellular Matrix (ECM) remodelling, and redox homeostasis maintenance.

Epidemiological study of trauma in children aged 0 to 14: Analysis based on data from 4450 children in a Level I trauma center in northwestern China.

Research on the epidemiological characteristics of pediatric trauma in specific regions is limited, making it necessary to conduct corresponding investigations. This study aims to understand the epidemiological characteristics of trauma patients aged 0 to 14 years, providing a reference for the prevention and enhancement of pediatric trauma care. The study analyzed the basic information of 4450 trauma patients aged 0 to 14 years who received treatment at a Level 1 trauma center in Northwest China from June 1, 2022, to May 31, 2024.

LA-peptide Hydrogel-Regulation of macrophage and fibroblast fates and their crosstalk via attenuating TGF-β to promote scarless wound healing.

The homeostasis of the wound microenvironment is fundamental for scarless wound healing, while the excessive accumulation of transforming growth factor-beta (TGF-β) in the wound microenvironment always leads to hypertrophic scars (HS) formation by regulating cell fates and crosstalk among various types of cells, such as macrophages and fibroblasts. This study reports that an injectable, self-assembling LA-peptide hydrogel has the potential to facilitate scarless cutaneous wound healing through dynamically adsorbing TGF-β within the wound environment. We found that the released LA peptides led to the suppression of both the PI3K/Akt and TGF-β/Smad2/3 pathways in macrophages and fibroblasts.

Impact of Public Health and Social Measures on Cosmetic Treatments in the COVID-19 Pandemic: A Retrospective Multi-Center Study Combined With a Questionnaire-Based Cross-Sectional Study.

Background: Public health and social measures (PHSMs) are considered the most effective approaches for controlling epidemic diseases. This study aimed to explore variations in the time-dependent characteristics of and public preferences for cosmetic treatments during and after the implementation of PHSMs during the COVID-19 pandemic.

Method: Medical records from six medical institutions were extracted retrospectively.

Optical two-dimensional coherent spectroscopy of cold atoms.

We report an experimental demonstration of optical two-dimensional coherent spectroscopy (2DCS) in cold atoms. The experiment integrates a collinear 2DCS setup with a magneto-optical trap (MOT), in which cold rubidium (Rb) atoms are prepared at a temperature of approximately 200 µK and a number density of 10 cm. With a sequence of femtosecond laser pulses, we first obtain one-dimensional second- and fourth-order nonlinear signals and then acquire both one-quantum and zero-quantum 2D spectra of cold Rb atoms.

Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.

The pluripotency and differentiation states of embryonic stem cells (ESCs) are regulated by a set of core transcription factors, primarily Sox2, Oct4, and Nanog. Although their transcriptional regulation has been studied extensively, the contribution of posttranslational modifications in Sox2, Oct4, and Nanog are poorly understood. Here, using a CRISPR-Cas9 knockout library screen in murine ESCs, we identify the E3 ubiquitin ligase Stub1 as a negative regulator of pluripotency.

TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.

Autophagy represents a fundamental mechanism for maintaining cell survival and tissue homeostasis in response to physiological and pathological stress. Autophagy initiation converges on the FIP200-ATG13-ULK1 complex wherein the serine/threonine kinase ULK1 plays a central role. Here, we reveal that the E3 ubiquitin ligase TRIM27 functions as a negative regulatory component of the FIP200-ATG13-ULK1 complex.

Lotus seedpods biochar decorated molybdenum disulfide for portable, flexible, outdoor and inexpensive sensing of hyperin.

Biomass waste, a good candidate for advanced carbon materials for sustainable electrodes, is receiving more and more attention for high value-added materials because of its promising contribution to economic growth and sustainable development. We proposed a green co-hydrothermal approach to prepare lotus seedpods biochar (BC) decorated molybdenum disulfide (MoS) from waste lotus seedpods and precursors of MoS and a portable, flexible, outdoor and inexpensive sensing platform for hyperin on the integrated flexible three-electrode using U-disk potentiostat with smartphone was successfully developed. Structure and properties of MoS-BC were characterized, it was proved that BC improves microstructure and morphology, electronic conductivity, electrode stability and electrocatalytic properties of MoS.

Collective Resonance of D States in Rubidium Atoms Probed by Optical Two-Dimensional Coherent Spectroscopy.

Collective resonance of interacting particles has important implications in many-body quantum systems and their applications. Strong interactions can lead to a blockade that prohibits the excitation of a collective resonance of two or more nearby atoms. However, a collective resonance can be excited with the presence of weak interaction and has been observed for atoms in the first excited state (P state).

Interaction-free bidirectional multi-channel all-optical switching in a multi-level coupling atom-cavity system.

We propose a scheme of interaction-free bidirectional multi-channel all-optical switching in a multi-level coupling system consisting of four-level atoms confined in a cavity and coupled by a free-space control laser. A signal laser field is coupled into the cavity and excites two separate transitions of atoms simultaneously under the collective strong coupling condition. The transmission and reflection of signal fields form bidirectional output channels.

Green synthesis of kudzu vine biochar decorated graphene-like MoSe with the oxidase-like activity as intelligent nanozyme sensing platform for hesperetin.

It is an urgent need to exploit a potentially green, cost efficient and eco-friendly strategy for the utilization of waste kudzu vine. We developed a one-step green preparation of kudzu vine biochar (BC) decorated graphene-like molybdenum selenide (MoSe) with the oxidase-like activity as intelligent nanozyme sensing platform for voltametric detection of hesperetin (HP) in orange peel using the in-situ hydrothermal synthesis method. The structure and properties of MoSe-BC was characterized, and found that BC significantly improved electrochemical cycle stability, electronic conductivity, electrochemical active area, and electrocatalytic activity of MoSe.

A portable wireless intelligent electrochemical sensor based on layer-by-layer sandwiched nanohybrid for terbutaline in meat products.

The aim of this study is to develop a portable wireless intelligent nanosensor (PWIN) for rapid cost-effective on-site determination of terbutaline (TRA) residue in meat products outdoors in comparison with traditional nanosensor and high-performance liquid chromatography (HPLC). The layer-by-layer sandwiched nanohybrid fabricated by platinum-palladium nanoparticles, carboxylated graphene and graphene-like molybdenum disulfide displayed a wide linear range of 0.55-14.

A highly-sensitive and selective antibody-like sensor based on molecularly imprinted poly(L-arginine) on COOH-MWCNTs for electrochemical recognition and detection of deoxynivalenol.

A new strategy to mimic antibody for electrochemical recognition and detection of deoxynivalenol (DON) using a highly-sensitive and selective antibody-like sensor based on molecularly imprinted poly(l-arginine) (P-Arg-MIP) on carboxylic acid functionalized carbon nanotubes (COOH-MWCNTs) was proposed. l-arginine as functional monomer was screened to prepare imprinted electrode via its electro-polymerization in the presence of DON onto the surface of COOH-MWCNTs electrode coupled with theoretical calculation. Surface morphology, structural characteristics, and electrochemical properties of P-Arg-MIP/COOH-MWCNTs were characterized by SEM, EDS, FTIR, and CV, respectively.

Portable wireless intelligent sensing of ultra-trace phytoregulator α-naphthalene acetic acid using self-assembled phosphorene/TiC-MXene nanohybrid with high ambient stability on laser induced porous graphene as nanozyme flexible electrode.

The harm of pesticide residues to human health via environmental pollution in agriculture has recently become a significant livelihood issue. Herein, a new strategy for smart ultra-trace analysis of phytoregulator α-naphthalene acetic acid (NAA) residues in farmland environments and agro-products via machine learning (ML) using a nanozyme flexible electrode fabricated by two-dimensional phosphorene (BP) nanohybrid with graphene-like titanium carbide MXene (TiC-MXene) on the flexible substrate surface of laser-induced porous graphene (LIPG) is proposed. Highly ambient-stable BP nanohybrid with TiC-MXene is prepared by ultrasonic-assisted liquid-phase exfoliation in organic solvent containing grinding black phosphorus, cuprous chloride and, TiC-MXene that is obtained by selectively etching Al layers of TiAlC.

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.

Despite landmark therapy of chronic myelogenous leukemia (CML) with tyrosine kinase inhibitors (TKIs), drug resistance remains problematic. Cancer pathogenesis involves epigenetic dysregulation and in particular, histone lysine demethylases (KDMs) have been implicated in TKI resistance. We sought to identify KDMs with altered expression in CML and define their contribution to imatinib resistance.

Multiwalled Carbon Nanotube-N-Doped Graphene/Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfonate) Nanohybrid for Electrochemical Application in Intelligent Sensors and Supercapacitors.

In this study, we reported the preparation of a conducting polymeric/inorganic nanohybrid consisting of multiwalled carbon nanotubes (MWCNT), N-doped graphene (NGr), and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and its electrochemical application in intelligent sensors and supercapacitors. The multilayer thin film of the PEDOT:PSS-supported MWCNT-NGr nanohybrid was prepared by a facile layer-by-layer assembly strategy. The obtained conducting polymeric/inorganic nanohybrid modified electrode displayed superior electron transfer ability and a high specific surface area, which was used for electrochemical applications in intelligent sensors and supercapacitors.

Convergence and divergence focusing phenomena at the focal plane of ultrashort pulses.

Using the Richards-Wolf diffraction integral theory and the tightly focused ultrashort pulse vector model, the focusing phenomena at the focal plane of subcycle and few-cycle radially polarized ultrashort pulses are studied. The dynamic focusing is revealed at the focal plane. First, the subcycle or few-cycle ultrashort pulses shrink towards the focus.

Long range dipole-dipole interaction in low-density atomic vapors probed by double-quantum two-dimensional coherent spectroscopy.

Optical double-quantum two-dimensional coherent spectroscopy (2DCS) was implemented to probe interatomic dipole-dipole interactions in both potassium and rubidium atomic vapors. The dipole-dipole interaction was detected at densities of 4.81×10 cm and 8.

In-situ reduction of Ag on black phosphorene and its NH-MWCNT nanohybrid with high stability and dispersibility as nanozyme sensor for three ATP metabolites.

The environmental stability, water-processibility and life-span of black phosphorene (BP) severely limit the application of its electronic devices in aqueous system containing oxygen. We reported the controllable preparation of in-situ reduction and deposition of silver nanoparticles on the BP surface and its amino-functionalized multi-walled carbon nanotubes (NH-MWCNT) nanocomposite. With the addition of both NH-MWCNT and Ag, the BP-based nanocomposite was prepared by ultrasonic-assisted liquid-phase exfoliation and was dispersed in carboxymethyl cellulose sodium (CMC) aqueous solution.

Collision induced magnetic resonance in Cesium atoms.

The radiofrequency-optical double magnetic resonance in cesium atoms filled in a vapor cell is investigated experimentally. One resonant signal involving spin-exchange collisions is observed in the M type magnetic resonance spectrum. We solve Liouville equations describing the dynamics of the system and analyze the role of the spin-exchange collisions in the atomic population distributions under resonant conditions.

iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.

Reactive oxygen species (ROS) have emerged as important signaling molecules that play crucial roles in carcinogenesis and cytotoxic responses. Nrf2 is the master regulator of ROS balance. Thus, uncovering mechanisms of Nrf2 regulation is important for the development of alternative treatment strategies for cancers.

Epigenetic silencing of ASPP1 confers 5-FU resistance in clear cell renal cell carcinoma by preventing p53 activation.

Inactivation of p53 has been shown to correlate with drug resistance in tumors. However, in clear cell renal cell carcinoma (ccRCC), p53 is rarely mutated, yet the tumors remain highly insensitive to the conventional chemotherapeutic drugs. The underlying mechanisms responsible for the non-genetic p53 inactivation remain obscure.