Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway.

Objective: Oridonin, a tetracyclic diterpenoid derived from Rabdosia rubescens (Donglingcao), exhibits beneficial effects such as lowering blood pressure, antioxidant activity, and immune enhancement. Long-term exposure to silica nanoparticles (SiNPs) is known to induce pulmonary fibrosis, associated with endoplasmic reticulum stress and pyroptosis; however, the interaction between SiNPs and pyroptosis remains unreported. The mechanisms underlying the antifibrotic effects of oridonin require further investigation.

Predictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis.

Objective: To explore the diagnostic value of integrating blood cell analysis and coagulation function indicators in the staging of neuroblastic tumors, providing a robust basis for clinical decision-making.

Methods: A retrospective analysis was conducted on 137 pediatric neuroblastic tumors cases (2017-2024) at the Children's Hospital Affiliated to Shandong University. Patients were stratified into localized (INSS 1-2, Group 1) and advanced (INSS 3-4, Group 2) stages according to the INSS classification, with mature ganglioneuroma serving as the control group.

Revisiting hypertension prevalence and risk factors: prevalence of hypertension and risk of diabetes in China.

Background: Hypertension is a common and serious public health issue, with elevated blood pressure significantly increasing the risk of cardiovascular disease and diabetes. In adults, blood pressure values of 130–139 mm Hg/80–89 mm Hg are associated with an increasing relative risk of cardiovascular complications and mortality. According to the American College of Cardiology (ACC) / American Heart Association (AHA) criteria for the diagnosis of hypertension, this study aimed to describe the prevalence and risk factors for stage 1 (systolic blood pressure 130–139 mm Hg or diastolic blood pressure 80–89 mm Hg) and stage 2 (systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg) hypertension.

Unraveling m6A RNA methylation: From epitranscriptomics to therapeutic frontiers in renal cell carcinoma.

N6-methyladenosine (m6A) RNA methylation has emerged as a crucial regulatory mechanism in cancer biology, influencing processes such as RNA splicing, stability, translation, and degradation. Renal cell carcinoma (RCC), often referred to as a silent cancer, is one of the most common malignancies of the urinary tract and is associated with poor prognosis and inadequate treatment options. m6A modifications play a pivotal role in RCC tumorigenesis, metastasis, progression, immune response modulation, and therapy resistance.

IGFBP3 modulation of tumor pathogenesis and cell signaling pathways (Review).

Insulin-like growth factor binding protein 3 (IGFBP3) is the primary carrier of circulating insulin-like growth factors and is the most extensively studied protein among the six high-affinity insulin-like growth factor binding proteins. Alterations in IGFBP3 at both the transcriptional and post-translational levels may contribute to the occurrence and progression of tumors. The present review focused on the changes in expression levels of IGFBP3 in tumors, as well as the relationship between the activation and inhibition of associated cell signaling pathways, and alterations in cellular biological behavior, aiming to provide a reference for the precise treatment of tumors.

The Effect of Different Temperature Management Strategies in Adult Sepsis Patients: A Meta-Analysis of Randomized Controlled Trials.

This investigation seeks to assess the impact of various temperature management approaches on the rates of death and organ failure among adult patients suffering from sepsis. A comprehensive search of PubMed, Embase, and CENTRAL was performed to identify randomized controlled trials (RCTs) published up to September 2024. These trials examined the impact of temperature management strategies on sepsis patients.

Genome-Wide Identification, Characterization, and Expression Analysis of Family Genes in '' Tea Under Abiotic Stress.

The () family comprises plant-specific transcription factors, which are distinguished by atypical bHLH domains. Over the past two decades, genetic and biochemical studies have established that members of the () family are crucial for regulating the expression of genes involved in brassinosteroid (BR) response in rapeseed. Due to the significance of the gene family, extensive research has been conducted to investigate its functional properties.

A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis.

Objectives: The study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).

Methods: Various databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.

Elevating VAPB-PTPIP51 integration repairs damaged mitochondria-associated endoplasmic reticulum membranes and inhibits lung fibroblasts activation.

Long-term silica exposure to silica dust leads to irreversible pulmonary fibrosis, during which lung fibroblast activation plays an essential role. Mitochondria-associated endoplasmic reticulum membranes (MAMs) is a structural interface for communication between the outer mitochondrial membrane and the endoplasmic reticulum. VAPB-PTPIP51 is a key complex on MAMs.

Construction of a risk prediction model of diquat poisoning based on clinical indicators.

This study aims to explore the clinical characteristics and prognostic factors in patients with diquat (DQ) poisoning and to develop a clinical risk assessment model to improve diagnosis and treatment strategies. Data from 60 patients with DQ poisoning, including basic characteristics, poisoning severity, and inflammatory response indicators, were collected. The plasma concentration of DQ was measured using liquid chromatography-mass spectrometry.

Identification and Expression Analysis of TCP Transcription Factors Under Abiotic Stress in .

The gene family encodes plant transcription factors crucial for regulating growth and development. While genes have been identified in various species, they have not been studied in (Hemsl.).

The Vital Role of the Gene Family in in Response to Drought, Heat, and Light Stress.

The calmodulin-binding transcriptional activator (CAMTA) is a small, conserved gene family in plants that plays a crucial role in regulating growth, development, and responses to various abiotic stress. Given the significance of the gene family, various studies have been dedicated to uncovering its functional characteristics. In this study, genome-wide identification and bioinformatics analysis were conducted to explore s in .

Association between cardiovascular health and serum vitamin D and its interaction with prediabetes and diabetes.

Background: Prediabetes and diabetes are common and serious public health problems, and high blood glucose can lead to serious cardiovascular complications. The purpose of this article was to explore the link between CVH levels and the incidence of prediabetes and diabetes in people over 20 years old, and whether serum vitamin D status could alter this relationship.

Materials And Methods: Data from six consecutive cycles of the NHANES database from 2007 to 2018 were combined and eligible participants were aged ≥20 years.

Analysis of the UDP-Glucosyltransferase () Gene Family and Its Functional Involvement in Drought and Salt Stress Tolerance in .

Uridine diphosphate glycosyltransferases (UDP-GTs, UGTs), which are regulated by genes, play a crucial role in glycosylation. In vivo, the activity of genes can affect the availability of metabolites and the rate at which they can be eliminated from the body. genes can exert their regulatory effects through mechanisms such as post-transcriptional modification, substrate subtype specificity, and drug interactions.

Genome Identification and Expression Profiling of the Gene Family in under Abiotic Stresses.

PIN-formed (PIN) proteins-specific transcription factors that are widely distributed in plants-play a pivotal role in regulating polar auxin transport, thus influencing plant growth, development, and abiotic stress responses. Although the identification and functional validation of genes have been extensively explored in various plant species, their understanding in woody plants-particularly the endangered species (Hemsl.) Yang-remains limited.

Relation extraction in Chinese using attention-based bidirectional long short-term memory networks.

Relation extraction is an important topic in information extraction, as it is used to create large-scale knowledge graphs for a variety of downstream applications. Its goal is to find and extract semantic links between entity pairs in natural language sentences. Deep learning has substantially advanced neural relation extraction, allowing for the autonomous learning of semantic features.

Photochemical degradation in natural attenuation of characteristics of petroleum hydrocarbons (C-C) in crude oil polluted soil by simulated long term solar irradiation.

Photodegradation process plays an important role in the natural attenuation of petroleum hydrocarbons (PHs) in oil contaminated soil. The photodegradation characteristics of PHs (C-C) in topsoil of crude oil contaminated soil irradiated by simulated sunlight in 280 d without microbial action were investigated. The results showed that photodegradation rate of PHs was increased with increasing the light intensity and decreased with increasing the initial concentration of PHs.

Protease-Activated Receptor-2 and Phospholipid Metabolism Analysis in Hyperuricemia-Induced Renal Injury.

Interstitial inflammation is an important mechanism of pathological damage in renal injury caused by hyperuricemia. Protease-activated receptor-2 (PAR2) is a class of targets that act upstream of the PI3K/AKT/NF-B pathway and is involved in various inflammatory diseases. We induced a hyperuricemia model in rats by adenine and ethambutol gavage in an experiment.

Heme Oxygenase 1/Peroxisome Proliferator-Activated Receptor Gamma Pathway Protects Intimal Hyperplasia and Mitigates Arteriovenous Fistula Dysfunction by Regulating Oxidative Stress and Inflammatory Response.

Purpose: An arteriovenous fistula (AVF) is the preferred vascular access mode for maintenance hemodialysis, and access stenosis and thrombosis are the primary causes of AVF dysfunction. This study is aimed at exploring the molecular mechanisms underlying AVF development and the roles of the heme oxygenase 1/peroxisome proliferator-activated receptor gamma (HO-1/PPAR-) pathway in AVF.

Method: AVF model mice were established, and the vascular tissues from the arteriovenous anastomosis site were sent for mRNA sequencing.

Crosstalk Between Histone and mA Modifications and Emerging Roles of mA RNA Methylation.

RNA, like DNA and proteins, has been discovered to undergo dynamic and reversible chemical alterations, increasing the diversity and functional complexity of the molecule. N-6-methyladenosine (mA) RNA methylation serves as a bridge between transcription and translation and is critical for many diseases' progression. There is a complex interrelationship between mA modifications and other epigenetic modifications.

How to Improve Entrepreneurship Education in "Double High-Level Plan" Higher Vocational Colleges in China.

Entrepreneurship education complements vocational education in helping students develop their career prospects. This empirical study comprehensively analyzed sample data of 13,885 students from 40 "Double High-level Plan" higher vocational colleges in China using robust standard error regression analysis and other methods. The results showed that Entrepreneurship Practice (EP), Entrepreneurship Curriculum (EC), and Integration of Entrepreneurship Education and Professional Education (IEEPE) have a significant positive effect on Entrepreneurship Education Performance (EEP), with EP being the most important factor.

CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice.

CD38 is the main enzyme for nicotinamide adenine dinucleotide (NAD) degradation in mammalian cells. Decreased NAD levels are closely related to metabolic syndromes and aging-related diseases. Our study showed that CD38 deficiency significantly alleviated angiotensin II (Ang II)-induced vascular remodeling in mice, as shown by decreased blood pressures; reduced vascular media thickness, media-to-lumen ratio, and collagen deposition; and restored elastin expression.

Correlation between histone H3K4 trimethylation and DNA methylation and evaluation of the metabolomic features in acute rejection after kidney transplantation.

Objective: To investigate the difference between trimethylation of monocyte histone H3K4 and DNA methylation in acute rejection (AR) after renal transplantation in rats and reveal the epigenetic mechanism of the AR rats based on metabolomics.

Method: Peripheral blood mononuclear cells (PBMCs) were isolated, and CD CD Treg cells were sorted by flow cytometry. The Foxp3 mRNA and protein levels of CD CD Treg cells were detected by real-time RT-PCR and Western blotting, respectively.

Association between Nod-like receptor protein 3 inflammasome and gouty nephropathy.

Crystalized deposits of monosodium urate activate the Nod-like receptor protein 3 (NLRP) inflammasome, resulting in kidney damage. The present study investigated whether the NLRP inflammasome is associated with the progression of hyperuricaemia and gouty nephropathy. Adult male patients were recruited at the Affiliated Baoan Hospital of Shenzhen and divided into three groups of 15 patients each: The control group, the hyperuricaemia group and the gouty nephropathy group.