Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: To explore the diagnostic value of integrating blood cell analysis and coagulation function indicators in the staging of neuroblastic tumors, providing a robust basis for clinical decision-making.
Methods: A retrospective analysis was conducted on 137 pediatric neuroblastic tumors cases (2017-2024) at the Children's Hospital Affiliated to Shandong University. Patients were stratified into localized (INSS 1-2, Group 1) and advanced (INSS 3-4, Group 2) stages according to the INSS classification, with mature ganglioneuroma serving as the control group. Univariate and multivariate logistic regression analyses were performed to identify differences in blood cell analysis and coagulation function indicators between groups, complemented by ROC curve analysis to evaluate the efficacy of the models.
Results: The median age of patients with neuroblastic tumor was 23.5 (12-46.75) months (male:female = 1.55:1), which was significantly younger than that of ganglioneuroma patients [72 (53-108) months, < 0.01]. Multinomial logistic regression identified age, RDW-CV, Fib, and Hb as independent predictors of advanced stages. Older age, higher RDW-CV and Fib levels were positively associated with advanced-stage risk compare to localized stages, while higher Hb showed a negative association. Furthermore, a probability prediction model developed using age, TT, Mon#, and Hb successfully differentiated advanced neuroblastic tumors from ganglioneuroma. The overall accuracy of this prediction model was 78.10%, with specific accuracies of 68.40%, 82.40%, and 80.00% for the localized neuroblastic tumors, advanced neuroblastic tumors, and ganglioneuroma groups, respectively. ROC curves showed AUCs of 0.867 (localized vs. advanced) and 0.941 (advanced vs. ganglioneuroma), indicating high diagnostic efficacy.
Conclusion: The combined analysis of age, RDW-CV, Hb, Mon#, Fib, and TT can effectively assist in the preliminary assessment of whether children with neuroblastic tumors are in an advanced phase or suffering from ganglioneuroma. This method enhances the accuracy and efficiency of clinical diagnosis and serves as a crucial reference for developing disease diagnosis and treatment plans.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331486 | PMC |
| http://dx.doi.org/10.3389/fonc.2025.1575863 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Surprise Diagnosis of a Lumbar Mass: Cytological Diagnosis of Retroperitoneal Ganglioneuroma in a Rare Presentation.
Diagn Cytopathol
August 2025
Department of Pathology and Lab Medicine, All Institute of Medical Sciences, Raebareli, Uttar Pradesh, India.
Ganglioneuromas (GNs) are the rare benign tumors belonging to the spectrum of the neuroblastic tumors and can be found anywhere across the distribution of the sympathetic nervous system, including the retroperitoneum. The majority of retroperitoneal GNs are asymptomatic and are diagnosed incidentally. We present a case of a retroperitoneal GN presenting as a palpable lumbar swelling, scoliosis, and inability to walk in a 6-year-old child, diagnosed on fine needle aspiration cytology (FNAC) and confirmed on histopathology.
View Article and Find Full Text PDFRare Presentation of Cervical Ganglioneuroma: A Case Report.
Cureus
July 2025
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mohammed VI, Faculty of Medicine and Pharmacy, Abdelmalek Essaadi University, Tangier, MAR.
Ganglioneuromas are rare, benign neoplasms of autonomic origin that represent the most differentiated end of the spectrum of peripheral neuroblastic tumors. Most commonly found in the posterior mediastinum and retroperitoneum, cervical involvement is distinctly uncommon. These tumors usually remain asymptomatic until they exert pressure on surrounding structures.
View Article and Find Full Text PDFRobot-assisted surgery for pediatric tumors: A single-center study of 114 cases.
Surgery
August 2025
Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children'
Purpose: Although robot-assisted surgery has been widely adopted for adult malignancies, its application in pediatric oncology remains contentious because of limited evidence. This study aims to assess the safety, feasibility, and surgical indications of robot-assisted surgery in pediatric oncology.
Method: A retrospective analysis was conducted on pediatric patients who underwent robot-assisted surgery at the Department of Surgical Oncology, Beijing Children's Hospital, between June 2021 and January 2024.
[An update on the pathology of peripheral neuroblastic tumors].
Ann Pathol
August 2025
Department of Biopathology CHRU-ICL, CHRU de Nancy, Vandœuvre-lès-Nancy, France; Inserm, U1256, NGERE, University of Lorraine, Vandœuvre-lès-Nancy, France. Electronic address:
Peripheral neuroblastic tumors correspond to a generic term for a heterogeneous spectrum of tumors: neuroblastomas, ganglioneuroblastomas (mixed and nodular), and ganglioneuromas. In current practice, the term neuroblastoma is often used because it represents the most frequent and most aggressive tumor component. It is a common tumor in children with heterogeneous morphological, biological and clinical presentations, but with an often unfavorable prognosis.
View Article and Find Full Text PDFPredictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis.
Front Oncol
July 2025
Clinical Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, China.
Objective: To explore the diagnostic value of integrating blood cell analysis and coagulation function indicators in the staging of neuroblastic tumors, providing a robust basis for clinical decision-making.
Methods: A retrospective analysis was conducted on 137 pediatric neuroblastic tumors cases (2017-2024) at the Children's Hospital Affiliated to Shandong University. Patients were stratified into localized (INSS 1-2, Group 1) and advanced (INSS 3-4, Group 2) stages according to the INSS classification, with mature ganglioneuroma serving as the control group.