Relationship between carotid-femoral pulse wave velocity and decreased left ventricular diastolic function in patient with coronary heart disease: a cross-sectional study.

Background: Arterial compliance is an independent predictor of diastolic dysfunction. Invasive catheterization can accurately reflect diastolic function. However, studies on the invasive assessment of diastolic function are currently limited.

A comparative study of bone density in elderly people measured with AI and QCT.

Background: Osteoporosis, a systemic skeletal disorder characterized by deteriorated bone microarchitecture and low bone mass, poses substantial fracture risks to aging populations globally. Early detection of reduced bone mineral density (BMD) through opportunistic screening is critical for preventing fragility fractures. Although dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis, many patients have not undergone screening with this technique.

Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation.

Background: Liver fibrosis is a progressive pathological process primarily driven by the transdifferentiation of hepatic stellate cells (HSCs) into myofibroblast-like cells which secrete excessive extracellular matrix (ECM). Although microRNAs (miRNAs) have emerged as key regulators of fibrogenesis, the therapeutic potential and mechanistic specificity of miR-214-3p (miR-214) in liver fibrosis remain insufficiently defined.

Methods: An adeno-associated virus (AAV)-based system was used to achieve either whole-liver or HSC-specific overexpression of miR-214 (via GFAP promoter) in a mouse model of alcohol-associated liver fibrosis induced by Lieber-DeCarli ethanol diet combined with low-dose CCl₄ injection.

Pangenome analysis reveals yield- and fiber-related diversity and interspecific gene flow in Gossypium barbadense L.

Gossypium barbadense is renowned for its superior fiber quality, particularly its extra-long fibers, although its fiber yield is lower compared to G. hirsutum. Here, to further reveal fiber-related genomic variants of G.

Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning.

Background: Recent studies have suggested a potential association between gastric cancer (GC) and myocardial infarction (MI), with shared pathogenic factors. This study aimed to identify these common factors and potential pharmacologic targets.

Methods: Data from the IEU Open GWAS project were used.

A non-linear association of low-density lipoprotein cholesterol with all-cause and cardiovascular mortality among patients with hypertension.

Background: Although a few studies have examined the correlation between low-density lipoprotein cholesterol (LDL-C) and mortality, no study has explored these associations in hypertensive populations. This study aims to investigate the relationship between low-density lipoprotein cholesterol and cardiovascular and all-cause mortality in adults with hypertension.

Methods: Hypertensive participants aged ≥18 years from the National Health and Nutrition Examination Survey 1999-2018 with blood lipid testing data and complete follow-up data until 31 December 2019 were enrolled in the analysis.

Predictive value of percutaneous peripheral arterial compliance T in left ventricular diastolic function with coronary artery disease.

Background: Diastolic dysfunction emerges early in patients with cardiac insufficiency and is prevalent, underscoring the importance of its early identification and intervention in the prevention of heart failure. The study leverages the convenience and accuracy of measuring peripheral arterial sclerosis to facilitate the early detection of diastolic dysfunction, which is instrumental in mitigating and delaying the onset and progression of heart failure, holding significant clinical relevance.

Methods: This research enrolled 556 patients suspected of experiencing Acute Coronary Syndrome (ACS) and stratified them into Groups A, B, C, and D according to the severity of coronary artery stenosis.

Two new compounds from biotransformation of glycyrrhetinic acid.

Glycyrrhetinic acid may undergo biotransformation to obtain derivatives with stronger pharmacological activity and fewer side effects. This study used 19 fungi to biotransform glycyrrhetinic acid and yielded two compounds namely bicyclo(14.15.

If They Won't Know, I Won't Wait: Anticipated Social Consequences Drive Children's Performance on Self-Control Tasks.

This research evaluated the hypothesis that the act of offering an incentive produces anticipated social benefits that are distinct from the benefits associated with the incentive itself. Across three preregistered studies, 3- to 5-year-old children in China (total = 210) were given an opportunity to wait for an additional sticker (Studies 1 and 3) or an edible treat (Study 2). Rewards were dispensed via a timer-controlled box that allowed the experimenter's apparent ability to learn how long children waited to be manipulated experimentally.

Analysis of the efficacy of abdominal massage on functional constipation: A meta-analysis.

Background: Constipation is a digestive disorder with a high global prevalence, with approximately 20-25% of the population suffering from constipation, and the majority of constipated patients experience functional constipation (FC). Although abdominal massage is an effective intervention, there is a lack of analysis of the efficacy of abdominal massage in the treatment of functional constipation. Objective: To evaluate the clinical efficacy of abdominal massage in the treatment of functional constipation.

Correction: Marginal zinc deficiency alters the heart proteome of rats.

Correction for 'Marginal zinc deficiency alters the heart proteome of rats' by Yongzhi Sun , , 2023, https://doi.org/10.1039/d2fo03815c.

Marginal zinc deficiency alters the heart proteome of rats.

Zinc deficiency is closely related to cardiovascular diseases (CVDs), but the effects of marginal zinc deficiency (MZD) after birth on the heart are unknown. In this study, 4-week-old male rats were fed a low zinc diet (10 mg kg, 1/3 recommended nutrient intake, RNI) for 8 weeks. Echocardiography and histopathology were performed to assess the functional and morphological alterations of the heart.

Biological Synergy and Antimicrobial Mechanism of Hydroxypropyltrimethyl Ammonium Chloride Chitosan with Benzalkonium Chloride.

Preservatives in eye drops have always been the focus of people's attention. Benzalkonium chloride (BAC) is one of the most frequently used bacteriostatic agents in eye drops, which has broad-spectrum and efficient bactericidal ability. However, the inappropriate dosage of BAC may lead to high cytotoxicity.

The role of DKK1 in Alzheimer's disease: A potential intervention point of brain damage prevention?

Dickkopf-1 (DKK1), a secretory glycoprotein discovered for 'inducing generation of head', is an endogenous inhibitor of the canonical Wnt/β-catenin signaling pathway. It was found to be involved in many pathophysiological processes in vivo. Abnormal expression of DKK1 will alter expressions of related proteins and genes not only in canonical Wnt/β-catenin signaling pathway but also in other signaling pathways.

CuSe Modification onto Monoclinic BiVO for Enhanced Photocatalytic Activity Under Visible Light.

The rapid recombination of electron-hole pairs in BiVO has limited its performance as a photocatalysis. In this paper, BiVO is combined with CuSe semiconductor to slow down the recombination process, and thus improve its photocatalytic activity. This is enabled by careful band structure design.

User-centric quality of experience optimized resource allocation algorithm in VLC network with multi-color LED.

Visible light communication (VLC) can provide indoor illumination while achieving high network throughput. In order to mitigate the performance degradation caused by inter-cell interference (ICI) and support multiple users, this paper utilizes the white LED synthesized by multi-color light sources as indoor illumination and signal transmissions. Compared with ordinary LEDs, multi-color LEDs not only has excellent color rendering index, but also realize multi-channel parallel transmission, which greatly improves the transmission speed of VLC.

Short period PM2.5 prediction based on multivariate linear regression model.

A multivariate linear regression model was proposed to achieve short period prediction of PM2.5 (fine particles with an aerodynamic diameter of 2.5 μm or less).