Enhancing Stability and Capacity in Planar Zn-Ion Micro-Batteries via 3D Porous Ni Anode Integration.

The development of planar on-chip micro-batteries with high-capacity electrodes and environmentally friendly and stable architectures is critical for powering the next generation of miniaturized system-on-chip smart devices. However, realizing highly stable micro-batteries remains a major challenge due to complex fabrication processes, electrode degradation during cycling, and the uncontrolled growth of dendrites in metal-based anodes within the confined spaces between electrodes. To address these issues, this study presents an approach that incorporates a 3D porous nickel (Ni) scaffold at the metal anode, offering improved micro-anode stability compared to conventional planar zinc and 3D porous zinc (Zn) scaffolds.

Associations between dietary index for gut microbiota with COPD prevalence and all-cause mortality: insights from the 1999-2018 NHANES data.

Objective: Gut microbiota dysbiosis plays a vital role the pathogenesis of chronic obstructive pulmonary disease (COPD). This study aimed to: (1) examine the cross-sectional association between dietary index for gut microbiota (DI-GM), a novel biomarker reflecting gut microbiota composition and function, and COPD prevalence; and (2) assess the prognostic significance of DI-GM score for all-cause mortality in COPD patients.

Methods: We analyzed data from the 1999-2018 National Health and Nutrition Examination Survey.

Morphological changes after corneal stromal lenticule excimer laser shaping.

The present study aimed to investigate the feasibility and design of producing a parallel/concave lenticule using an excimer laser on a convex corneal matrix lenticule . Optical coherence tomography was used to measure the thickness of the corneal stromal lenticules. Lenticules were cut using an excimer laser.

200 W 1 mJ picosecond laser amplification in a Yb:YAG disk and single-crystal fiber cascade amplifier.

A hundred-watt millijoule-level disk and single-crystal fiber cascade amplifier were demonstrated. We innovatively adopted a disk regeneration amplifier as the front end of the single-crystal fiber amplifier. After single-pass amplification by the single-crystal fiber amplifier, a hundred-watt millijoule picosecond laser output is obtained with an average power of 210.

Enhancing oxygen adsorption via the synergistic catalysis of graphitic nitrogen carbon and antiperovskite ZnCNi in Zinc- Air batteries.

The key to the commercial available of Zinc Air batteries (ZABs) is to design and exploit the low-cost and high efficiency bifunctional oxygen electrocatalysts. Here, it is reported that a bifunctional electrocatalyst consisting of nitrogen-rich carbon nanotubes encapsulating antiperovskite ZnCNi nanoparticles grafted onto the surface of carbon nanofibers (ZnCNi-NCCF) for rechargeable ZABs. The electrocatalytic activity of ZnCNi-NCCF is promoted by the synergistic catalysis of graphitic nitrogen-doped carbon and antiperovskite ZnCNi.

Highly Conserved Genetic Factors Regulating Gene Expression.

The New Delhi metallo--lactamase (NDM; EC 3.5.2.

Numerical Study of Wear Characteristics of Vertical Shaft Planetary Mixer Blades.

The wear failure of vertical shaft planetary mixer blades under complex working conditions directly affects the quality and productivity of concrete. Given that it is time-consuming and labor-intensive to obtain the wear characteristics of mixer blades by experimental methods, this study used numerical simulation to analyze the effects of different factors on the wear characteristics of mixer blades based on the Hertz-Mindlin with JKR cohesive contact model and the Archard wear model. The results of this study show that under the influence of different factors, the blade is subjected to tangential cumulative contact energy and contact force is significantly larger than that in the normal direction, the wear of the blade is judged to be the form of abrasive wear accompanied by impacts, and the wear on the outer middle and lower edge regions of the blade is the most serious.

3D Porous Zinc Scaffold Anodes for Enhanced Stability and Performance in Zinc-Ion Energy Storage Systems.

Irregular Zn plating and stripping behaviors, along with the growth and detachment of Zn dendrites, pose a critical challenge to the rechargeability of zinc (Zn)-ion energy storage systems. In this study, a dynamic hydrogen bubble template (DHBT) method is introduced to construct an 3D porous Zn scaffold on a Zn foil anode, which acts as a stable host to address morphological inhomogeneities during cycling. The pore walls provide abundant nucleation sites, effectively confining Zn growth within the scaffold and preventing vertical penetration into the separator.

Acupuncture modulates ovarian senescence through metabolic reprogramming: A multi-omics investigation in chemotherapy - induced POF model.

Premature ovarian failure (POF) is a common female endocrine disorder in women, and there is currently no effective pharmacological treatment available. Acupuncture, an important component of traditional Chinese medicine, has demonstrated clinical efficacy in improving ovarian function in patients with POF; however, its underlying mechanisms remain unclear. This study systematically investigated the therapeutic mechanisms of acupuncture in cyclophosphamide (CTX)-induced POF through combined analysis of proteomic and metabolomic data.

Role of Tropomodulins in brain physiology and pathology.

Actin dynamics are crucial for the morphogenesis and function of neurons in the brain. Tropomodulins (Tmods) belong to a family of actin-binding proteins that cap the pointed-end of actin filaments. There are four Tmod isoforms, and three of which, Tmod1, Tmod2 and Tmod3, are expressed in the brain, with Tmod2 exhibiting neuronal specific expression.

Antioxidant, Hypoglycemic, and Hypolipidemic Effects of Puerarin In Vivo.

Puerarin (PUE) exhibits various pharmacological effects. This study evaluated its antioxidant, hypoglycemic, and hypolipidemic effects in vivo using models of aging, diabetes, and hyperlipidemia. D-galactose-induced aging, streptozotocin (STZ)-induced diabetic, and high-fat diet-induced hyperlipidemic mouse models were established.

Dietary Tea Polyphenols Alleviate Acute-Heat-Stress-Induced Death of Hybrid Crucian Carp HCC2: Involvement of Modified Lipid Metabolisms in Liver.

Background: Global warming poses significant challenges to aquaculture, as elevated water temperatures adversely affect fish health and survival. This study investigated the effects and potential mechanisms of dietary tea polyphenols (TPs) on acute heat stress and survival in hybrid crucian carp HCC2.

Methods: The fish in the control (CON) group and heat stress group (HS group, three replicates, each containing 20 fish, = 60 per group) were fed diets with 0 mg/kg TPs, and the three experimental groups (HSLTP, HSMTP, and HSHTP, = 20 × 3 replicates) were fed the diets with 100, 200, or 400 mg/kg TPs for 60 days.

Novel anti-pyroptosis drug loaded on metal-organic framework for intervertebral disc degeneration therapy.

Intervertebral disc degeneration (IVDD) is the main cause of low back pain, pyroptosis is a major contributor to various diseases, including IVDD; however, there is currently no effective drugs targeting pyroptosis for therapy. In this study, we established pyroptosis model in nucleus pulposus cells (NPCs) and searched pyroptosis inhibitors in FDA Medicine Library. High throughput screening study revealed that Pirfenidone (PFD) was the most effective pyroptosis inhibitor among 1500+ FDA drugs, which was confirmed by further experiments.

Impact of Oil Temperature and Splashing Frequency on Chili Oil Flavor: Volatilomics and Lipidomics.

In this study, headspace gas chromatography-ion mobility spectrometry, headspace gas chromatography-mass spectrometry, and lipidomics were used to explore the effects of three oil temperatures (210 °C, 180 °C, 150 °C) with single- and traditional triple-oil-splashing processes (210 °C → 180 °C → 150 °C) on the formation of key chili oil aromas. A total of 31 key aroma compounds were identified, with 2,4-nonadienal, α-pinene, α-phellandrene, and β-ocimene being found in all treatment groups. Lipidomics suggested that oleic acid, linoleic acid, and α-linolenic acid were highly positively correlated with key chili oil key aroma compounds, such as (E)-2-heptenal, 2-methylbutyraldehyde, limonene, (E, E)-2,4-heptadienal, 2,4-nonadienal, and 2,4-decadienal.

Sevoflurane Inhibits the Proliferation of Neural Precursor Cells and Neural Migration of Mice by Inducing Iron Metabolism Disorders.

Background: Sevoflurane (Sev) is a volatile anesthetic and inhibits the proliferation of neural precursor cells (NPCs) and neuronal migration in the embryonic brain, thereby affecting offspring's cortical development and cognitive function.

Methods: Pregnant mice were treated with 2.5% Sev.

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin-Dependent Monooxygenase in Lasalocid A Biosynthesis.

Polyether polyketides are a structurally diverse group of natural products known for their antimicrobial and antiproliferative activities. Lasalocid A is a canonical natural polyether produced by the soil bacterium Streptomyces lasalocidi. In lasalocid A biosynthesis, a polyene polyketide intermediate is converted into a bisepoxide by the flavin-dependent monooxygenase enzyme Lsd18.

Ultrastructural changes of corneal stromal lenticule after laser shaping.

With the aim to improve the application of stromal lenticules derived from small-incision lenticule extraction (SMILE) surgery in treating refractive and corneal diseases, a technique was developed in the present study to reshape these lenticules by modifying their thickness distribution. For this, the ultrastructural changes in SMILE-derived corneal stromal lenticules following excimer laser reshaping were examined. SMILE was performed on 40 myopia using the VisuMax femtosecond laser system.

Enhancing antimicrobial activity through structural modification of Rip-thanatin with amino acid substitution.

Rip-thanatin (RipT), a natural antimicrobial peptide derived from Riptortus pedestrisc, is comprised of 18 amino acid residues. Herein, a series of Rip-thanatin derivatives were synthesized using cationic and amphiphilic design strategies of antimicrobial peptides (AMPs) by employing an amino acid replacement method. The results revealed that the cationic amino acid, arginine, exhibited superior antibacterial activity compared to lysine residues.

Artificial intelligence-driven quantitative analysis of CT morphological differences between chronic thromboembolic pulmonary hypertension and chronic thromboembolic disease.

Background: The morphological differences in the pulmonary vascular tree between chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic disease (CTED) are not yet fully understood. This study aimed to use artificial intelligence (AI) segmentation technology to identify morphological markers that can be used to differentiate CTEPH from CTED using computed tomography pulmonary angiography (CTPA).

Methods: We conducted a retrospective cohort study with consecutive patients diagnosed with CTEPH, CTED, and control subjects at the China-Japan Friendship Hospital from January 2019 to October 2023.

Improve the visualization effect of fingerprint immunolabeling based on biotin-avidin system.

Immunolabeling based on fluorescence is a new technique that has been recently applied in the field of forensic science. In this paper, a new immunofluorescence method based on signal amplification was applied to develop fingermarks and improve the quality of pattern recognition with clear ridge details and high contrast. The high affinity between biotin and avidin and the one-to-many binding mode can connect several fluorescent groups together to achieve a signal amplification effect.

Purification, structural characterization, and in vitro immunomodulatory activity of a low-molecular-weight polysaccharide from cultivated Chinese cordyceps.

Cultivated Chinese cordyceps, an optimal substitute for the endangered wild resource, has recently been produced on a large scale. This work sought to explore the structural features and immunomodulatory activity of a novel low-molecular-weight polysaccharide (CSP1a, 15.7 kDa) isolated from cultivated Chinese cordyceps.

Preparation and Hypoglycemic Effect of Magnolia Officinalis Polysaccharide Oral Liquid.

In this paper, an oral liquid containing Magnolia officinalis polysaccharide was formulated and its hypoglycemic effects were investigated. An orthogonal test was conducted based on single-factor experiments to optimize the formulation guided by sensory evaluations. Its stability and safety were also assessed.

Deep learning models for MRI-based clinical decision support in cervical spine degenerative diseases.

Purpose: The purpose of our study is to develop a deep learning (DL) model based on MRI and analyze its consistency with the treatment recommendations for degenerative cervical spine disorders provided by the spine surgeons at our hospital.

Methods: In this study, MRI of patients who were hospitalized for cervical spine degenerative disorders at our hospital from July 2023 to July 2024 were primarily collected. The dataset was divided into a training set, a validation set, and an external validation set.

A microfluidic chip incorporating magnetic sorting and invasive separation for isolation, culture and telomerase analysis of circulating tumor cells.

Circulating tumor cells (CTCs) are a crucial indicator of cancer metastasis, and are vital for early diagnosis, disease monitoring, and treatment response evaluation. However, their extremely low concentration and the complexities of isolation techniques pose a significant challenge in capturing and analyzing CTCs. In this study, we developed a novel microfluidic system that integrates magnetic capture and invasive screening onto a single microfluidic chip.