Exploring the threshold relationship between PTH level and P1NP level in patients with osteoporotic fractures: a retrospective cross-sectional study.

Background: PTH plays a crucial role in bone remodelling by regulating bone formation. Pre-collagen type 1 N-terminal peptide (P1NP) is a key biomarker indicative of new bone formation. However, the relationship between PTH levels and P1NP levels in patients with osteoporotic fractures (OPFs) has not been fully elucidated.

Is it advisable for Asians to drink milk, especially those at risk of osteoporosis?

Osteoporosis poses a significant health challenge globally, with particularly high rates anticipated in the Asian region in the forthcoming years. This region has been identified as a potential hotspot for increasing incidences of osteoporosis. Unfortunately, the Asian population has a low consumption of milk and dairy products, which may exacerbate this situation.

Polyvinyl alcohol-induced regulation of lysozyme crystal morphology: From hexagonal to petal-like structures.

Protein crystallization is essential in structural biology and drug development, with crystal morphology directly impacting diffraction quality and analytical accuracy. However, effective strategies for precisely controlling protein crystal morphology remain limited. Herein, we successfully regulated lysozyme crystal morphology using polyvinyl alcohol (PVA) as selective additive, exploiting the side-chain hydroxyl functional groups.

Functional characterization of CYP9J26, a cytochrome P450 associated with insecticide resistance in the arbovirus vector Aedes albopictus.

Aedes albopictus is a primary vector of arboviral diseases such as dengue fever, chikungunya fever, and Zika. The rapid development of insecticide resistance is becoming a major challenge to sustainability of insecticide-based interventions for the control of Ae. albopictus borne arboviral diseases.

The relationship between lung function and cognitive impairment among middle-aged and older adults: The mediating role of depressive symptoms.

Background: To date, the mechanisms underlying the relationship between lung function and cognitive decline remain poorly understood. This study aims to investigate the mediating effect of depression in the longitudinal association between lung function and subsequent cognitive impairment (CI).

Methods: In the China Health and Retirement Longitudinal Study (CHARLS), a total of 7275 participants were included in the final analysis.

RAGATH-Associated DNA Nuclease Assisted DNA Insertion in .

serves as a key microbial chassis for the industrial production of feed and food ingredients. While long DNA fragment insertion technologies have advanced strain engineering capabilities, previous approaches such as utilizing a chromosome-integrated Cas9-RecET system were constrained by a maximum insertion fragment size of 7.5 kb.

Synthesis and Electrochemiluminescence of a Di-Boron Thermally Activated Delayed Fluorescence Emitter.

Recent advances in electrochemiluminescence (ECL) leveraging thermally activated delayed fluorescence (TADF) have highlighted its potential for near-unity exciton harvesting. However, there are still very limited examples of TADF-ECL emitters. We present a rigid diboron-embedded multiple-resonance TADF emitter, which exhibits blue-green emission at 493 nm with a remarkably narrow bandwidth (FWHM = 22 nm) and minimized singlet-triplet energy gap (ΔE = 0.

Implementation of RAGATH RNA-associated DNA Endonucleases as Genome Editing Tool in Escherichia coli.

The preferred method for Escherichia coli genome editing relies on Cas9 from Streptococcus pyogenes (SpCas9) and λ-Red recombinase. Although SpCas9 is currently the most active RNA-guided DNA endonuclease, a significant number of escapers are often observed, making it inefficient across different sites, particularly when inserting large fragments. In this study, we identified two RAGATH RNA-associated DNA endonucleases (RADs) derived from IS607 transposons.

Milk Composition Is Predictive of Low Milk Supply Using Machine Learning Approaches.

The causes of low milk supply are multifactorial, including factors such as gene mutations, endocrine disorders, and infrequent milk removal. These factors affect the functional capacity of the mammary gland and, potentially, the concentrations of milk components. This study aimed to investigate the differences in milk composition between mothers with low and normal milk supply and develop predictive machine learning models for identifying low milk supply.

FTIR microscopic study on biomolecular alterations in placental tissues of intrahepatic cholestasis of pregnancy.

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder that typically leads to severe pregnancy outcomes. Although genetic, endocrine, and environmental factors are involved in the etiology of ICP, the role of metabolic disorders remains unclear. Here we report an examination of the biomolecular alterations in placental tissues of women with ICP and healthy pregnant women at a molecular level.

Insecticide resistance in the field populations of the Asian tiger mosquito in Beijing: resistance status and associated detoxification genes.

Background: (Skuse) is an invasive and widespread mosquito species that can transmit dengue, chikungunya, yellow fever, and Zika viruses. Its control heavily relies on the use of insecticides. However, the efficacy of the insecticide-based intervention is threatened by the increasing development of resistance to available insecticides.

A dual-drive strategy for enhanced protein crystallization with sodium alginate/hyaluronic acid film: Protein adsorption and supersaturation regulation.

Protein crystallization is essential for determining the three-dimensional structures of biomacromolecules and advancing biopharmaceutical development, yet it remains a major challenge in structural biology due to common issues like slow nucleation rates and inconsistent crystal quality. Herein, a dual-drive crystallization (DDC) strategy, relying on a composite film of sodium alginate (SA) and hyaluronic acid (HA), is reported to synergistically regulate both protein adsorption and solution supersaturation. Driven by the electrostatic interactions of SA and the water absorption properties of HA, the SA/HA film achieves enhanced crystallization efficiency and controlled crystal quality mainly.

[Essential oil of Acori Tatarinowii Rhizoma inhibits pyroptosis of microglia by regulating NLRP3 inflammasomes].

This study aims to investigate the effect of essential oil of Acori Tatarinowii Rhizoma on microglial pyroptosis and decipher the underlying mechanism. BV-2 cells were treated with 1 μg·mL~(-1) lipopolysaccharide(LPS) and 10 μmol·L~(-1) nigericin sodium salt for the modeling of pyroptosis. The cells were treated with different doses of essential oil of Acori Tatarinowii Rhizoma, and then the cell viability and apoptosis were examined by the CCK-8 assay and flow cytometry, respectively.

Shen Qi Wan regulates OPN/CD44/PI3K pathway to improve airway inflammation in COPD: Network pharmacology, bioinformatics, and experimental validation.

Background: Chronic obstructive pulmonary disease (COPD) is one of the most common respiratory diseases with undefined pathogenesis and unsatisfactory therapeutic options. Shenqi Wan (SQW), a traditional Chinese medicinal compound, has demonstrated certain preventive and therapeutic effects on COPD. However, the underlying molecular mechanisms remain incompletely understood.

Effects of exercise on sleep quality in general population: Meta-analysis and systematic review.

Purpose: Sleep is the foundation of human physiological health and psychological health, as well as one of the basic needs for human survival. Sleep quality problems are prevalent in the population, and poor sleep quality is often closely related to the occurrence of many diseases, which seriously affects the quality of life and may even result in a shortened lifespan, so that improving sleep health has become a real problem that needs to be solved urgently. Exercise, as an important non-pharmacological tool, has been widely used for sleep quality enhancement, while the efficacy of exercise on subjective and objective sleep with respect to individual sleep quality remains controversial.

The volatile oil of Acorus tatarinowii Schott ameliorates Alzheimer's disease through improving insulin resistance via activating the PI3K/AKT pathway.

Background: Alzheimer's disease (AD) presently stands as the most prevalent neurodegenerative disease. Existing research underscores the pivotal role of insulin signaling in the progression of AD. Acorus tatarinowii Schott (SCP), a traditional Chinese herbal, is employed for AD treatment in China.

Biogeochemical process governing cadmium availability in sediments of typical coastal wetlands driven by drying-wetting alternation.

Fluctuations in water levels within coastal wetlands can significantly affect cadmium (Cd) cycling and behavior in sediments. Understanding the effects of drying-wetting cycles on Cd availability and binding mechanisms is crucial. However, information regarding this subject remains limited.

The RING-Type E3 Ligase BOI Interacts with EXO70E2 and Mediates Its Ubiquitination in .

The exocyst is a hetero-octameric complex that exhibits significant functional diversity in regulating biological processes and defense responses. In plants, the EXO70 proteins are important components of the exocyst complex and are involved in membrane trafficking, biotic and abiotic interactions, as well as cell wall formation. A previous study has indicated that a member of the EXO subfamily, EXO70E2, interacts with RIN4 to mediate plant immunity.

Human milk lactoferrin and lysozyme concentrations vary in response to a dietary intervention.

It is known that human milk (HM) antimicrobial protein composition varies during lactation. However, the impact of maternal diet on these antimicrobial proteins, particularly lactoferrin and lysozyme remains unknown. In addition, it is unclear whether daily, circadian, and between breast variations exist for lactoferrin and lysozyme concentrations.

Fragmented Polymetric Carbon Nitride with Rich Defects for Boosting Electrochemical Synthesis of Hydrogen Peroxide in Alkaline and Neutral Media.

Electrocatalytic oxygen reduction reaction via 2e pathway is a safe and friendly route for hydrogen peroxide (HO) synthesis. In order to achieve efficient synthesis of HO, it is essential to accurately control the active sites. Here, fragmented polymetric carbon nitride with rich defects (DCN) is designed for HO electrosynthesis.

Integrated Quality of Service for Offline and Online Services in Edge Networks via Task Offloading and Service Caching.

Edge servers frequently manage their own offline digital twin (DT) services, in addition to caching online digital twin services. However, current research often overlooks the impact of offline caching services on memory and computation resources, which can hinder the efficiency of online service task processing on edge servers. In this study, we concentrated on service caching and task offloading within a collaborative edge computing system by emphasizing the integrated quality of service (QoS) for both online and offline edge services.

Strong Electronic Interaction in High-Entropy Oxide Enhances Oxygen Evolution Reaction.

High-entropy oxides are a new type of material with significant application potential. However, the lack of a universal HEO preparation method severely limits the property study and application of HEOs. Herein, we report a universal approach of spray pyrolysis for the preparation of various HEOs and study the electrocatalytic performance of HEOs toward the oxygen evolution reaction.

Shenqi Pill Mitigates Renal Interstitial Fibrosis Through Weakening Notch1/Jag1 Pathway.

Introduction: Shenqi pill (SQP) can be used to treat various kidney related diseases, but its exact mechanism of action remains unclear. We intended to analyze the role and mechanism of SQP on renal interstitial fibrosis (RIF).

Methods: After performing unilateral ureteral obstruction (UUO) surgery following the Institutional Animal Care and Use Committee guidelines, all rats were assigned into the sham group, UUO group, UUO + SQP 1.

Efficient Biosynthesis of Salidroside via Artificial enhanced UDP-Glucose System Using Cheap Sucrose as Substrate.

Salidroside, a valuable phenylethanoid glycoside, is obtained from plants belonging to the genus, known for its diverse biological properties. At present, salidroside is still far from large-scale industrial production due to its lower titer and higher process cost. In this study, we have for the first time increased salidroside production by enhancing UDP-glucose supply .

U-shaped relationship found between fibrinogen-to-albumin ratio and systemic inflammation response index in osteoporotic fracture patients.

The relationship between the Systemic Inflammatory Response Index (SIRI) and the Fibrinogen-to-albumin ratio (FAR) has not been extensively investigated. The objective of this study was to determine the independent relationship between FAR and SIRI in people with osteoporotic fractures (OPF). A cross-sectional study was conducted using retrospective data from 3431 hospitalized OPF patients.