Flexible Microneedle Platform for Synergistic Chemo/Photothermal Ferroptosis Therapy via P-Glycoprotein Inhibition in Breast Cancer.

Combining photothermal therapy (PTT) with chemotherapy shows promise for cancer treatment, but its efficacy is limited by heat shock protein (HSP)-induced thermoresistance and P-glycoprotein (P-gp)-mediated drug efflux. To overcome these challenges, we developed a tumor microenvironment-responsive microneedle platform for synergistic chemotherapy, PTT, and ferroptosis in breast cancer. The system employs Fe-coordinated dihydromyricetin (DMY) nanocarriers encapsulating doxorubicin (DMFD NPs) integrated into a flexible polyvinylpyrrolidone (PVP) microneedle patch.

Copper peroxide-triggered reactive nitrogen effectively enhanced synergistic chemodynamic-immunotherapy.

Overcoming the limitations of chemodynamic therapy (CDT), constrained by the transient nature and limited bioavailability of reactive oxygen species (ROS), this study proposes a synergistic strategy integrating CDT with immunotherapy. We engineered a multifunctional nanocarrier, HMSN-Met@HA-CuO₂, leveraging CuO to amplify intracellular ROS generation and induce cuproptosis. Concurrently, metformin (Met) releases nitric oxide (NO), which scavenges ROS to generate more stable reactive nitrogen species (RNS).

Metal-polyphenol nanoparticles-loaded carboxymethyl cellulose-based microneedle for promoting the healing of diabetic wounds.

Inflammation and infection are significant barriers to the healing of diabetic wounds. Infectious wounds are often associated with the formation of bacterial biofilms, which impede the penetration of conventional drugs. In this study, we developed a novel metal-polyphenol composite nanoparticle (EGCG-Cu NPs) by combining epigallocatechin gallate (EGCG) with Cu and incorporated these nanoparticles into microneedles (MNs) made from polyvinylpyrrolidone (PVP) and sodium carboxymethyl cellulose (CMCNa).

Glucose oxidase-embedded mesoporous polydopamine nanoparticles produce CO for synergistic tumor starvation, chemodynamic, and photothermal therapy.

Starvation therapy, developed by exploiting glucose oxidase (Gox) to convert glucose into gluconic acid and hydrogen peroxide (H₂O₂), represents a promising approach to treating tumors that heavily rely on the glycolysis pathway to meet their high energy demands. However, the efficacy of Gox monotherapy is hindered by the hypoxic tumor microenvironment and activation of energy compensation mechanisms. In this study, we present a novel multimodal therapeutic nanoplatform that synergistically integrates starvation therapy with photothermal therapy (PTT) and chemodynamic therapy (CDT) to overcome these limitations.

Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy.

Cancer remains a significant global health challenge due to its high mortality rates and the limitations of conventional therapies, which are often associated with severe side effects and limited efficacy. Calcium (Ca) overload therapy has emerged as a promising strategy for inducing tumor cell apoptosis. However, existing methods that rely on direct Ca delivery often face limited efficacy due to tumor adaptation mechanisms.

A sustained HS-releasing nanocellulose-based hydrogel with anti-inflammatory and antibacterial properties for promoting infected wound healing.

Infected wounds present unique challenges during healing, often characterized by prolonged inflammation and delayed tissue recovery. To address these issues, we developed a composite hydrogel (CAEG), which integrated a hydrogen sulfide (HS) donor (GYY4137), carboxylated nanocellulose (CNF-C) and ε-polylysine (ε-PL). This hydrogel was designed to enhance wound healing by mitigating inflammation and preventing infections.

Light-triggered release of nitric oxide from chitosan-based cationic hydrogels for promoting infected wounds healing.

Infected wounds are highly susceptible to bacterial contamination, which not only delays the healing process but also leads to a range of complications. NO is one of the most widely used gas molecules in wound treatment strategies due to its potent antibacterial and healing-promoting properties. However, excessive NO in infected wounds can damage cellular components and exacerbate inflammation.

Curdlan/xanthan gum-based composite hydrogel with near-infrared irradiation responsive properties for infected wounds healing.

Open wounds are prone to bacterial contamination and delayed healing due to environmental exposure, necessitating the development of advanced wound dressings. Hydrogels are ideal candidates for wound care for maintaining a moist environment which benefits for the cell migration and tissue regeneration. However, conventional polysaccharide hydrogels lack intrinsic antibacterial properties, prompting the incorporation of antibacterial agents.

Protocatechuic acid grafted chitosan/oxidized glucomannan hydrogel with antimicrobial and anti-inflammatory effects for enhancing wound repair.

Oxidative stress, inflammation, and bacterial infection are critical barriers to wound healing. In this work, a composite wound dressing was designed to promote wound healing and reduce complications. A hydrogel with antibacterial, anti-inflammatory, and antioxidant properties was prepared by crosslinking chitosan (CS) and oxidized konjac glucomannan with Mg.

Hyaluronic acid-based ε-polylysine/polyurethane asymmetric sponge for enhanced wound healing.

Asymmetric sponge dressings with a hydrophobic surface and a hydrophilic inner layer can prevent bacterial infiltration and ensure efficient absorption of wound exudate. In this work, ε-polylysine/aliphatic polyurethane sponge (EPU) was prepared by prepolymer foaming process, and oxidized hyaluronic acid (OHA) was cross-linked with ε-polylysine (EPL) in EPU through schiff-base reaction to obtain EHPU. Octaisobutyl polyhedral oligomeric silsesquioxane (Oi-POSS) was uniformly sprayed onto the surface of EHPU as the hydrophobic layer, resulting in asymmetric sponge dressings denoted as P-EHPU.

Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy.

The combination of chemodynamic therapy (CDT) with photothermal therapy (PTT) is a promising approach to enhance antitumor efficacy of chemotherapeutics. In this paper, we developed novel copper-chelated polydopamine (PDA) nanoparticles (NPs) functionalized with hyaluronic acid (HA) (Cu-PDA-HA NPs) to induce apoptosis and cuproptosis-induced cell death, synergistically combining PTT and CDT. Experimental results revealed that Cu-PDA-HA NPs can respond to excessive glutathione (GSH) and hydrogen peroxide (HO) in the tumor microenvironment (TME), which will enable their specific degradation, thereby leading to efficient accumulation of Cu within tumor cells.

Heterojunction functionalized sodium alginate/carboxylated cellulose nanocrystals film enhancing sterilization performance for wound healing.

In the realm of natural polysaccharides, hydrogen bonding is a prevalent feature, yet its role in enhancing photocatalytic antimicrobial properties has been underexplored. In this paper, heterojunctions formed by graphene oxide (GO) and ZIF-8 were locked in sodium alginate/ carboxylated cellulose nanocrystals via hydrogen bonding networks, designated as SCGZ. The SCGZ films exhibit superior photocatalytic performance compared to either ZIF-8 or heterojunctions.

Zeolitic imidazolate framework-8@polydopamine decorated carboxylated chitosan hydrogel with photocatalytic and photothermal antibacterial activity for infected wound healing.

Open wounds are susceptible to bacterial infections, and antibiotics are commonly used to treat these infections. However, widespread use of antibiotics will easily induce bacterial resistance. Green antibacterial agents serve as excellent alternative for antibiotics in infection therapy.

Disulfiram-loaded CuO nanocarriers for enhanced synergistic chemodynamic chemotherapy.

Disulfiram (DSF) metabolites exhibit antitumor properties when bound to Cu. This combination also promotes the generation of reactive oxygen species (ROS), ultimately leading to tumor cell death. In this study, CuO served as a carrier for DSF, forming a dual-drug delivery system with Cu and DSF encapsulated in polydopamine (PDA).

Dextran-Based Antibacterial Hydrogel Dressings for Accelerating Infected Wound Healing by Reducing Inflammation Levels.

Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected wounds more effectively, aerogel-hydrogel biphase gels based on dextran are developed. The gel introduced in this study exhibits antibacterial and anti-inflammatory properties in the process of wound therapy, contributing to accelerated wound healing.

Polydopamine-Modified Copper Coordination Mesoporous Silica Nanoparticles Loaded with Disulfiram for Synergistic Chemo-Photothermal Therapy.

Disulfiram (DSF) degrades to diethyldithiocarbamate (DTC) in vivo and coordinates with copper ions to form CuET, which has higher antitumor activity. In this study, DSF@CuMSN-PDA nanoparticles were prepared using mesoporous silica with copper ions, DSF as a carrier, and polydopamine (PDA) as a gate system. The nanoparticles selectively released CuET into tumor tissue by taking advantage of the tumor microenvironment, where PDA could be degraded.

In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy.

The Cu complex formed by the coordination of disulfiram (DSF) metabolite diethyldithiocarbamate (DTC), Cu(DTC), can effectively inhibit tumor growth. However, insufficient Cu levels in the tumor microenvironment can impact tumor-suppressive effects of DTC. In this study, we proposed a Cu and DSF tumor microenvironment-targeted delivery system.

pH/glutathione dual-responsive copper sulfide-coated organic mesoporous silica for synergistic chemo-photothermal therapy.

Nanodrug delivery systems (NDSs), such as mesoporous silica, have been widely studied because of their high specific surface area, high loading rate, and easy modification; however, they are not easily metabolized and excreted by the human body and may be potentially harmful. Hence, we aimed to examine the synergistic anti-tumor effects of ex vivo chemo-photothermal therapy to develop a rational and highly biocompatible treatment protocol for tumors. We constructed a biodegradable NDS using organic mesoporous silica with a tetrasulfide bond structure, copper sulfide core, and folic acid-modified surface (CuS@DMONs-FA-DOX-PEG) to target a tumor site, dissociate, and release the drug.

Redox and pH dual sensitive carboxymethyl chitosan functionalized polydopamine nanoparticles loaded with doxorubicin for tumor chemo-photothermal therapy.

The high expression of reduced glutathione (GSH) and low pH in tumor sites have encouraged new ideas for targeted drug release. The tumor microenvironment is a crucial target for studying the anti-tumor efficiency of photothermal therapy because the microenvironment plays a key role in cancer progression, local resistance, immune escaping, and metastasis. Herein, active mesoporous polydopamine nanoparticles loaded with doxorubicin and functionalized with N,N'-bis(acryloyl)cystamine (BAC) and cross-linked carboxymethyl chitosan (CMC) were used to induce simultaneous redox- and pH-sensitive activity to achieve photothermal enhanced synergistic chemotherapy.

A quaternized chitosan and carboxylated cellulose nanofiber-based sponge with a microchannel structure for rapid hemostasis and wound healing.

A hemostatic sponge should perform rapid hemostasis and exhibit antibacterial properties, whilst being non-toxic, breathable, and degradable. This study prepared a hemostatic sponge (CQTC) with microchannels, specifically a microchannel structure based on quaternized chitosan (QCS) and carboxylated cellulose nanofibers (CCNF) obtained by using tannic acid and Cu complex (crosslinking agent). The sponge had low density and high porosity, while being degradable.

In vitro Antitumor Properties of Fucoidan-Coated, Doxorubicin-Loaded, Mesoporous Polydopamine Nanoparticles.

Chemotherapy is a common method for tumor treatment. However, the non-specific distribution of chemotherapeutic drugs causes the death of normal cells. Nanocarriers, particularly mesoporous carriers, can be modified to achieve targeted and controlled drug release.