Genome-wide identification and expression profiles of the superoxide dismutase (SOD) genes in Lentinula edodes.

The superoxide dismutase (SOD) enzymes are a group of key enzymes involved in oxidative stress defense and play a significant role in organismal growth and development. The SOD gene family has been identified in many plants, animals, and some fungi but not in the economically important edible mushroom Lentinula edodes. In this study, members of the SOD gene family of L.

Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein.

Newcastle disease virus (NDV) is a significant enveloped virus within the Paramyxoviridae family, posing a major threat to the global poultry industry. Increasing evidence suggests that cholesterol-25-hydroxylase (CH25H) and its enzymatic product, 25-hydroxycholesterol (25HC), exhibit broad-spectrum antiviral activity properties by modulating lipid metabolism and various signaling pathways. However, the specific role of CH25H in regulating NDV infection and replication remains unclear.

Immunogenicity and protective efficacy of a novel bacterium-like particle-based vaccine displaying canine distemper virus antigens in mice and dogs.

Unlabelled: Canine distemper virus (CDV) poses a severe threat to both domesticated and wild animals, including multiple carnivores. With the continued expansion of its host range, there is an urgent need for the development of a safer and more effective vaccine. In this study, we developed subunit vaccines based on a bacterium-like particle (BLP) delivery platform containing BLPs-F and BLPs-H, which display the CDV F and H glycoprotein antigens, respectively, using the antigen-protein anchor fusions produced by a recombinant baculovirus insect cell expression system.

Protection against genotype VII Newcastle disease virus by a mucosal subunit vaccination based on bacterium-like particles bearing the F or HN antigen.

Genotype VII Newcastle disease viruses (NDV) are still epidemic in many countries in chicken and waterfowl despite intensive vaccination with conventional live and inactivated vaccines. Here, we developed an effective mucosal subunit vaccine based on a bacterium-like particles (BLPs) delivery platform derived from Lactococcus lactis. The NDV protective antigen F or HN fused protein anchor (PA) was expressed by recombinant baculovirus and loaded on the surface of BLPs, resulting in BLPs-F and BLPs-HN, respectively.

Genotypic and Phenotypic Characterization of Some Hypervirulent Clinical Isolates of in a Tertiary Hospital in Hefei, Anhui.

Background: is a highly successful pathogen that can cause various infectious diseases, from relatively mild skin infections to life-threatening severe systemic diseases. The widespread pathogenicity of is mainly due to its ability to produce many virulence factors that help destroy various host cells, causing disease. Our primary goal in this study was to explore the genes of highly virulent strains, to identify genes closely associated with high virulence, and to provide ideas for the treatment of infection by highly virulent clinical strains.

Peptidoglycan-associated lipoprotein contributes to the virulence of Acinetobacter baumannii and serves as a vaccine candidate.

The role of peptidoglycan-associated lipoprotein (Pal) in A. baumannii pathogenesis remains unclear. Here, we illustrated its role by constructing a pal deficient A.

Molecular Epidemiology of in a Tertiary Hospital in Anhui, China: ST59 Remains a Serious Threat.

Purpose: This study aimed to investigate the molecular characteristics, antimicrobial resistance and hemolytic phenotype of isolated from Anhui, China.

Results: From August 2021 to January 2022, 214 isolates were collected from the Anhui Provincial Hospital. This study identified 117 methicillin-resistant and 97 methicillin-sensitive isolates, and the detection rate of methicillin-resistant isolates was 1.

Chicken bone marrow mesenchymal stem cells improve lung and distal organ injury.

Mesenchymal stem cells (MSCs) are associated with pulmonary protection and longevity. We separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs can improve lipopolysaccharide (LPS)-induced lung and distal organ injury; and explored the underlying mechanisms. Ninety-six male ICR (6 weeks old) mice were randomly divided into three groups: Sham, LPS, and LPS + MSC groups.

Complete Genome Sequence of Community-Acquired Methicillin-Resistant Staphylococcus aureus Strain RJ1267, Isolated in Shanghai, China.

Staphylococcal pathogens, especially multidrug-resistant , are responsible for various clinical infections. Multilocus sequence type 630 (ST630) methicillin-resistant has been shown to have augmented pathogenicity in humans. In this announcement, we report the complete genome sequence of community-acquired methicillin-resistant strain RJ1267 of ST630.