Molecular Epidemiology of in a Tertiary Hospital in Anhui, China: ST59 Remains a Serious Threat.

Infect Drug Resist

Department of Oncology, The First Affiliated Hospital, University of Science and Technology of China, Hefei, People's Republic of China.

Published: February 2023


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Article Abstract

Purpose: This study aimed to investigate the molecular characteristics, antimicrobial resistance and hemolytic phenotype of isolated from Anhui, China.

Results: From August 2021 to January 2022, 214 isolates were collected from the Anhui Provincial Hospital. This study identified 117 methicillin-resistant and 97 methicillin-sensitive isolates, and the detection rate of methicillin-resistant isolates was 1.8-fold higher than the average isolates reported in China (53.9% vs 30.5%). isolates share identity at five or more of the seven MLST-based housekeeping loci, referred to as the clonal complex (CC). Forty ST types were found in 214 clinical isolates, with the most extensive distribution of ST59 and ST6697 typing numbers and higher CC5 detection rates than any other clonal group. (The ST typing is the result of the MLST typing website query.) To detect the virulence of ST types of , hemolysis experiments were performed on 214 clinical isolates, and it was concluded that ST59 had a relatively robust hemolytic capacity.

Conclusion: Anhui isolates have unique molecular and antibiotic resistance profiles. The antibiotic resistance profile may be related to the random use of antibiotics.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9940498PMC
http://dx.doi.org/10.2147/IDR.S395220DOI Listing

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