Identification of the ZmATG18 subfamily genes in maize and the role of ZmATG18a in drought stress.

Background: Autophagy represents an ancient cytoprotective program that sustains cell viability under metabolic or environmental stresses via targeted recycling of cellular components. However, the contribution of ATG18s in maize is ambiguous.

Results: This work aims to identify and characterize the maize ZmATG18 subfamily genes at the whole-genome level and a total of eight ZmATG18 subfamily genes were identified.

Analysis of bleeding after ultrasound-guided core needle biopsy of infected cervical lymph nodes.

Purpose: This study aimed to determine the incidence of bleeding after core needle biopsy (CNB) of infected cervical lymph nodes and analyze the factors associated with bleeding after CNB, and preventive measures of bleeding.

Methods: We retrospectively analyzed the records of 643 patients with infectious cervical lymphatic ganglionic diseases who underwent CNB at our hospital from December 2015 to February 2022. The number of patients with bleeding after CNB, extent of bleeding, and type of disease were recorded and statistically analyzed.

Palladium-Catalyzed Decarbonylative Borylation of Benzylic Acids for the Synthesis of Benzylboronates.

A palladium-catalyzed decarbonylative borylation of benzylic carboxylic acids by selective C-O cleavage is reported. A variety of benzylic acids bearing different functional groups are well tolerated by this method. The reaction accomplishes the synthesis of valuable pinacol benzylboronates from common benzylic acids by net decarbonylation.

Epigenetic Activation of CCDC183-AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis.

Bone metastasis (BM) is a major contributor to poor prognosis of prostate cancer (PCa); however, the underlying mechanisms of PCa BM remain poorly understood. A better understanding of these processes may provide critical insights for developing effective preventive and therapeutic strategies for PCa BM. In this study, significant upregulation of CCDC183-AS1 in PCa BM is identified, which is associated with disease progression.

Preparation and characterization of double-coated slow-release urea fertilizer encapsulated with polymethylmethacrylate and sulfonated cellulose derivatives modified sodium alginate hydrogel.

The utilization of cellulose in preparation of slow-release fertilizer (SRF) is still challenging due to its inherent drawbacks such as low solubility and fragility. Herein, based on the preparation of sulfonation cellulose (SC) and sequential synthesis of corresponding SC based hydrogel (SC-SAH) by crosslinking the above-formed SC derivative with sodium alginate (SA), a novel double-coated SRF with urea granules as core was developed by utilizing polymethylmethacrylate (PMMA) as internal coating and the SC-SAH as external coating (SC-SAH/PMMA@Urea-SRF). The optimization on the preparation conditions of the hydrogels and SRFs together with the comprehensive characterizations demonstrate that SC-SAH possesses a higher swelling capacity and hydrophilicity.

Spin-state-regulated dual-metal orbital engineering in heterostructured nanosheets for d-band center-optimized electrocatalytic water splitting.

A dual-metal orbital engineering strategy is developed to synergistically optimize active site reactivity and bulk-phase stability through precise d-band center modulation and enhanced charge transfer kinetics. Specifically, a flower-like NiMn selenide nanoarchitecture, modified with silver nanoparticles and sulfur-doped carbon quantum dots (Ag/NiSe/MnSe/S-CQDs), is fabricated via controlled spin state regulation. The asymmetric configuration between NiSe and MnSe induces a significant elevation in the energy levels of Ni's e and t orbitals, thereby optimizing intermediate conductivity, e orbital electron occupancy, and adsorption free energy.

Colorimetric detection of fluoroquinolones via MOF inhibition and thiol-response oxidase-mimicking reactions.

Developing a selective colorimetric assay for fluoroquinolones (FQs) that show visible color response is highly desired, which is challenging because FQs show extremely similarity in structure and inherently absorb light in the UV color range. In this work, a selective colorimetric assay for pefloxacin (PEF) was fabricated through integrating two rection systems: the inhibition effects of PEF on the AChE-like activities of Al decorated MOF-808 (MOF-808-Al) and the thiol-response oxidase-mimicking reaction of MnO nanosheets. The MnO nanosheets, due to their oxidase-mimicking properties, can oxidize the colorless 3, 3', 5, 5'-tetramethylbenzidine (TMB) into its blue-colored oxidized form, TMB.

Value of contrast-enhanced ultrasound assisted core needle biopsy in the diagnosis of cervical lymph node tuberculosis.

Aim: To investigate the value of contrast-enhanced ultrasound (CEUS) assisted core needle biopsy (CNB) in the diagnosis of cervical lymph node tuberculosis (LN TB) and improve the positive rate of cervical LN TB.

Methods: We retrospectively analyzed 730 samples obtained from July 2010 to January 2025 from patients treated with effective antituberculosis therapy and with microbiologically confirmed and surgical pathologically proven cervical lymph node enlargement who had undergone CEUS- CNB at our hospital. All patients were divided into two groups according to the historical control method.

Phosphatidylethanolamine Protects Nucleus Pulposus Cells From Oxidative Stress-Induced Cellular Senescence and Extracellular Matrix Degradation by Promoting Autophagy.

Background: Intervertebral disc degeneration (IDD) is a type of musculoskeletal system diseases that prevail widely in human society, exerting a substantial economic burden on society. The extensive aggregation of senescent nucleus pulposus (NP) cells within the discs is a significant characteristic of lumbar degenerative alterations. Exploring the underlying mechanisms of NP cell senescence and developing strategies to retard cell senescence are anticipated to become effective approaches for the treatment of IDD.

Phosphatidylcholine Ameliorates Palmitic Acid-Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration.

Background: Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal disorder with substantial socioeconomic impacts. Despite its high prevalence, the pathogenesis of IDD remains unclear, and effective pharmacological interventions are lacking. This study aimed to investigate metabolic alterations in IDD and explore potential therapeutic targets by analyzing lipotoxicity-related mechanisms in nucleus pulposus (NP) cells.

Modified Minimally Invasive Transforaminal Microscope-Assisted Fusion to Treat Lumbar Foraminal Stenosis Combined with Severe Lumbar Degenerative Diseases.

Objective: Lumbar foraminal stenosis combined with severe lumbar degenerative disease causing instability, radiculopathy, and claudication may require surgery. The surgical treatment goals are decompression, restoration of the height of the disc and foramina, and stabilize the spine. We used a modified minimally invasive transforaminal lumbar interbody fusion (TLIF) approach in those patients and evaluated its clinical efficacy.

Development and validation of a predictive model for diagnosing EBER-positive lymphoma-associated hemophagocytic lymphohistiocytosis.

Purpose: This study aims to identify distinguishing factors between EBER-positive lymphoma-associated hemophagocytic lymphohistiocytosis and non-neoplastic EBV-associated hemophagocytic lymphohistiocytosis. Additionally, we developed and validated a predictive diagnostic model based on these factors.

Methods: To evaluate the early identification of individuals with EBER-positive lymphoma-associated hemophagocytic lymphohistiocytosis versus non-neoplastic EBV-associated hemophagocytic lymphohistiocytosis, we carried out a retrospective cohort research.

Effect of π-Bridge Chain Rearrangement in a Sensitizer on Photovoltaic Performance of Dye-Sensitized Solar Cells.

In this paper, novel triphenylamine (TPA)-based photosensitizers (, , , and ) with a donor-π-acceptor (D-π-A) structure are developed for dye-sensitized solar cells by rearrangement of planar thiophene and thienothiophene with a benzene ring as a π-bridging chain. Density functional theory calculations are performed to obtain the HOMO-LUMO electron cloud density distribution, dipole moment (μ), intermolecular torsion angle (θ), three-dimensional (3D) molecular structure, and electrostatic potential surface (ESP) maps of the dyes. The effects of π-bridge chain rearrangement and dye cosensitization on the photophysical, electrochemical, and photovoltaic properties of the devices are investigated through experiment analysis.

Unraveling the PVT-mPFC circuit: A new frontier in chronic pain management for bone cancer pain.

Bone cancer pain (BCP) is a type of ongoing or breakthrough pain caused by a primary bone tumor or bone metastasis. BCP impairs patients' quality of life. Depending upon clinical observations, the administration of centrally acting analgesic has been associated with the alleviation of pain symptoms BCP patients.

Rapid and in-depth reconstruction of fluorine-doped bimetallic oxide in electrocatalytic oxygen evolution processes.

Most transition metal-based electrocatalysts, when used for the oxygen evolution reaction (OER), undergo significant restructuring under alkaline conditions, forming localized oxides/hydroxides (MOOH), which act as the real active centers, activating adjacent metal sites and creating new active sites that enhance electrocatalytic behavior. Nevertheless, inducing rapid and in-depth self-reconstruction of catalyst surfaces remains a huge challenge. Herein, this work achieves rapid and in-depth self-reconstruction by doping fluorine into the lattice of transition metal oxides (MO).

Bloodstream infections in pediatric hematology/oncology patients: a single-center study in Wuhan.

Bloodstream infections (BSIs) are a critical concern in pediatric onco-hematological patients undergoing chemotherapy or hematopoietic stem cell transplantation (HSCT), leading to a major impact on morbidity, long-term hospitalization, and mortality. We retrospectively analyzed 202 BSIs in 145 patients, consisting of 128 with hematological malignancies, one with a solid tumor, and 16 with non-malignant hematological diseases. We collected data on patient demographics, clinical characteristics, pathogen distribution, and antimicrobial pathogen susceptibility.

The role of CEUS in diagnosing tuberculous abscess of the right diaphragm.

Purpose: To evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in detecting tuberculous diaphragmatic abscess (TDA) of the right diaphragm and provide a reference for its clinical diagnosis.

Methods: A retrospective analysis was conducted on 33 patients with right TDA confirmed via surgery and biopsy. The diagnostic accuracy of CEUS and routine ultrasound for detecting right TDA was compared.

Numerical simulation and experimental study on guidance performance of hypersonic seeker under aerodynamic optical transmission effects.

When a hypersonic seeker flies at high speed within the atmosphere, intense interaction with the incoming flow gradually develops into a complex turbulent flow field. This interaction results in complex thermal responses at the seeker window, causing aerodynamic optical effects such as image shift, jitter, and blur of the target image, thereby restricting the seeker's detection capability and accuracy. This paper uses a numerical simulation model for the guidance performance of a hypersonic seeker under aerodynamic optical transmission effects.

Regional subsidence monitoring and prediction along high-speed railways based on PS-InSAR and LSTM.

The rapid construction of high-speed railways in China has forced more and more routes to pass through slow subsidence zones caused by groundwater extraction or underground mining. It is crucial to carry out deformation monitoring and prediction those areas along high-speed railways to ensure the safe operation. Twenty-nine periods of Sentinel-1A data between Taiyuan South Station and Taigu East Station were first processed using the PS-InSAR technique, and the ground subsidence sequences at ten typical points were selected.

Distinct Pathways Gene Expression Profiles in Pediatric De Novo Acute Lymphoblastic and Myeloid Leukemia with Mutations: Implications for Targeted Therapy.

Activating mutations plays a crucial role in leukemogenesis, but identifying the optimal candidates for inhibitor therapy remains controversial. This study aims to explore the impacts of mutations in pediatric acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) and to compare the mutation profiles between the two types to inspire the targeted application of inhibitors. We retrospectively analyzed 243 ALL and 62 AML cases, grouping them into -mutant and wild-type categories, respectively.

Ionic liquid-assisted synthesis of InO nanoparticles for ppb-level NO sensing at low temperature.

Highly sensitive detection of nitric dioxide (NO) has recently attracted much attention due to its harmful to the human health even at a low concentration of 0.1 parts per million (ppm). Herein, InO nanoparticles (NPs) were prepared via a facile ionic liquid (IL) assisted solvothermal method with subsequent calcination and then were analyzed through the characterization of X-ray diffractometer (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS) and nitrogen adsorption-desorption techniques.

Preparation and characterization of starch carbamate modified natural sodium alginate composite hydrogel blend formulation and its application for slow-release fertilizer.

The exploration of environmentally friendly slow-release fertilizer (SRF) based on natural bio-polymers is of great importance in the development of modern agriculture and horticulture. Herein, a novel starch carbamate (SC) modified sodium alginate (SA) hydrogel (SC/SAH) was prepared utilizing as-synthesized SC and natural SA through the cationic ions crosslinking method and ultimately the corresponding slow-release fertilizer (SC/SAH-SRF) was successfully developed by immersing the dried SC/SAH matrix into saturated urea solution. Due to the low gelation temperature and high viscosity of the synthesized SC, the formed SC/SAH exhibits significantly enhanced properties including excellent water absorbency up to 8.

Efficacy and safety of combinations of H1 antihistamines in the treatment of urticaria: A scoping review.

The efficacy and safety of combining H1 antihistamines (AHs) for treating urticaria are currently unclear. This scoping review aims to provide a comprehensive overview of the evidence regarding the efficacy and safety of H1 AH combinations in the management of urticaria up to May 2023. The search encompassed databases such as PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and the China Biological Medicine Database.

The value of histopathologic examination and Xpert (MTB/RIF) assay in diagnosis of cervical lymph node tuberculosis after coarse needle biopsy guided by CEUS: a retrospective analysis of 612 cases.

Objective: To investigate the value of histopathological examination (HPE) and Xpert Mycobacterium tuberculosis bacilli/rifampicin (MTB/RIF) assay in diagnosis of cervical lymph node tuberculosis (LN TB) after coarse needle biopsy (CNB).

Methods: We retrospectively analyzed 612 samples obtained from October 2017 to August 2023 from patients suspected cervical LN TB with surgically pathological, microbial culture confirmed, and clinically confirmed cervical lymph node enlargement who received ultrasound-guided CNB assisted by contrast-enhanced ultrasound (CEUS) at our hospital. All specimens were assessed by HPE and the Xpert (MTB/RIF) assay.