[Integration and innovation of wet granulation and continuous manufacturing technology: a review of on-line detection, modeling, and process scale-up].

Continuous manufacturing, as an innovative pharmaceutical production model, offers advantages such as high production efficiency and ease of control compared to traditional batch production, aligning with the future trend of drug production moving toward greater efficiency and intelligence. However, the development of continuous manufacturing technology in wet granulation has been slow. On one hand, this is closely related to its high technical complexity, substantial equipment investment costs, and stringent process control requirements.

[Spatiotemporal Variation and Trade-off Synergistic Relationship of Ecosystem Services in Gannan Prefecture].

The Gannan Tibetan Autonomous Prefecture, situated in the upper reaches of the Yellow River Basin, serves as a crucial ecological function area and an environmental fragile zone. Therefore, studying the changes in ecosystem services and their associated trade-offs in this region is important for sustainable development. This study focuses on the Gannan Prefecture, utilizing the InVEST model to analyze the spatio-temporal shifts in land use types from 1990 to 2020.

Multiple insect pollination contributes to differential phenotypic selection on floral traits in Stellera chamaejasme.

Background: Flower morphology is believed to be primarily shaped by the most important pollinators when more than one pollinating species visits the flowers. However, floral adaptation to the selection mediated by multiple pollinators has received little attention. The plant Stellera chamaejasme has evolved a pollination syndrome matching both lepidopteran and thrips.

Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound.

Backgrounds: The dried rhizome of Ligusticum sinense Oliv.cv. Chaxiong has been used to treat cardiovascular and cerebrovascular diseases, atherosclerosis, anemia and stroke.

Are fungi from adult orchid roots the best symbionts at germination? A case study.

We studied mycobionts from advanced seedlings and adult mycorrhizal roots of the terrestrial orchid Arundina graminifolia. Fungi were isolated, identified by ITS sequencing, and tested for their impact on seed germination, protocorm formation, and development of advanced seedlings (emergence of first leaf) in vitro. Among the six fungal species isolated, four were not standard orchid mycorrhizal fungi (Fusarium solani, Cylindrocarpon sp.