Publications by authors named "Ming-Yan Xia"
Article Synopsis
- Ibuprofen (IBU) has poor gastrointestinal absorption due to low solubility, prompting researchers to create a thermosensitive gel with ibuprofen-loaded solid lipid nanoparticles (IBU-SLN-ISG) for better dissolution and bioavailability through rectal delivery.
- The study optimized the IBU-SLN formulation using a design approach and characterized its physicochemical properties, revealing successful drug encapsulation and a favorable release profile with minimal rectal irritation.
- Tests showed that the IBU-SLN-ISG significantly improved IBU absorption and retention in the rectum, indicating its potential for further development as a more effective delivery system.
[Pharmacokinetic study on five components in phthalide target areas of Chaxiong and its β-CD inclusion compounds based on UPLC-MS/MS].
Zhongguo Zhong Yao Za Zhi
February 2021
This study aims to establish a method for the determination of the concentration of five main components of phthalide target areas of Chaxiong(CPTA) and its inclusion of β-CD in the plasma of rats, and determine the pharmacokinetic parameters, absolute bioavailability and relative bioavailability of CPTA/β-CD inclusion compound in vivo. The plasma concentrations of senkyunolide A, N-butylphthalide, new osthol lactone, Z-ligustilide and butenyl phthalide were determined with UPLC-MS/MS. The content determination was conducted at the chromatographic conditions as follows: Shim-pack GIST C_(18)-AQ HP column(2.
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