Critical predictors of heart transplant necessity in children with advanced DCM.

Background: Dilated Cardiomyopathy (DCM) frequently culminates in Heart Failure (HF), positioning it as the primary instigator of cardiac transplantation among pediatric patients. Nevertheless, the issue of cardiac transplantation in children demands a comprehensive and judicious strategy. The aim of this research was to ascertain the clinical attributes at the point of diagnosis that could potentially signal the requirement for transplantation in pediatric patients diagnosed with Dilated Cardiomyopathy (DCM).

Pediatric sequential organ failure assessment for predicting outcomes in ECMO-bridged pediatric heart transplant recipients: experience from the largest pediatric heart transplant center in China.

Objective: Advanced heart failure in children sometimes requires mechanical circulatory support as a bridge to transplantation, with extracorporeal membrane oxygenation (ECMO) remaining a critical option despite its associated risks. The pediatric Sequential Organ Failure Assessment (pSOFA) may have potential in evaluating prognosis in ECMO-bridged candidates.

Methods: 188 Children underwent orthotopic heart transplantation in Union hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2018 and April 2025 were studied retrospectively, with 24 received ECMO assistance as a bridge to transplant.

Mo-O-Sn Bond Boosting Kinetics of MoO-xSnO/Sn Anode for High-Performance Li-ion Batteries.

Obtaining a robust electrode composed of Sn-based metal oxides and carbonaceous matrix through nanoscale structure engineering is essential for effectively improving Li-ion batteries' electrochemical performance and stability. Herein, we report a bimetallic MoO-xSnO/Sn nanoparticles uniformly anchored on N, S co-doped graphene nanosheets (MoO-xSnO/Sn@NSG) as an anode electrode for Li-ion battery via a one-step hydrothermal and thermal treatment approach. In the MoO-xSnO/Sn nanocomposite, the generated Sn-O-Mo bond can modulate the electronic and composition structures to improve the intrinsic conductivity of SnO and reinforce the structural stability during cycles.

Clinical Outcomes and Risk Factors of Heart Transplantation Patients Experiencing Gastrointestinal Bleeding.

Gastrointestinal bleeding (GIB) after heart transplantation (HT) remains a significant clinical issue. This study aimed to explore the incidence, trends, outcomes, and clinical predictors of GIB in HT patients. Adult patients who underwent HT between 2015 and 2021 at Union Hospital were recruited and divided into two groups based on the presence or absence of postoperative GIB.

Neuroprotective effects and mechanisms of action of artemisinin in retinal ganglion cells in a mouse model of traumatic optic neuropathy.

Introduction: Traumatic optic neuropathy is known to be a critical condition that can cause blindness; however, the specific mechanism underlying optic nerve injury is unclear. Recent studies have reported that artemisinin, considered vital in malaria treatment, can also be used to treat neurodegenerative diseases; however, its precise role and mechanism of action remain unknown. Therefore, in this study, we aimed to investigate the impact and probable mechanism of action of artemisinin in retinal ganglion cells (RGCs) in a mouse model of traumatic optic neuropathy induced by optic nerve crush (ONC).

Hybrid Ascharite/Reduced Graphene Oxide with Polysulfide Adsorption Host for Advanced Lithium-Sulfur Batteries.

Balancing the adsorption of lithium-polysulfide intermediates on polar host material surfaces and the effect of their electronic conductivity in the subsequent oxidation and reduction kinetics of electrochemical reactions is necessary and remains a challenge. Herein, we have evaluated the role of polarity and conductivity in preparing a series of ascharite/reduced graphene oxide (RGO) aerogels by dispersing strong polar ascharite nanowires of varying mass into the conductive RGO matrix. When severed as Li-S battery cathodes, the optimized S@ascharite/RGO cathode with a sulfur content of 73.

Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice.

Background: Although heart transplantation is the definitive treatment for heart failure in eligible patients, both acute and chronic transplant rejection frequently occur. Protein phosphatase 2A (PP2A) activity is critical in maintaining tissue and organ homeostasis. In this study, we evaluated the effect of a novel class of small molecule activators of PP2A (SMAPs) on allograft rejection in a mouse heterotopic heart transplantation model.

Detoxification of the Toxic Sulfur Mustard Simulant by a Supramolecular Antidote in Vitro and in Vivo.

Although great potential hazards and threats still occur from sulfur mustard, there are no specific medicine or therapy for the intoxication of sulfur mustard. Herein, we have demonstrated a supramolecular approach for the detoxification of the sulfur mustard simulant () in vitro and in vivo by carboxylatopillar[5]arene potassium salts (CP[5]AK ) efficiently based on host-guest interactions. The encapsulation of () by the cavity of the pillar[5]arene is driven by C-H···π interactions between () and the electron-rich cavity of pillar[5]arene , which was investigated by H NMR titration, density functional theory studies, and the independent gradient model studies.