Efficacy of hypertonic saline nasal irrigation in allergic rhinitis: A systematic review and meta-analysis.

Saline nasal irrigation provides symptom relief in allergic rhinitis (AR), but the optimal saline concentration remains uncertain. The comparative efficacy of 3% hypertonic saline nasal irrigation (HSNI) versus 0.9% isotonic saline is still debated.

A bexarotene-attached Re(I) tricarbonyl complex for NADH oxidation and ROS-mediated cancer phototherapy.

An axially substituted polypyridyl Re(CO) complex bearing bexarotene triggered caspase-3/7-mediated apoptosis in cancer cells through ROS generation and NADH photo-oxidation.

Versatility of Temporalis Myofascial Flap in Maxillofacial Reconstruction: A Retrospective Study.

Aim: To evince the versatility of temporalis myofascial flap by assessing its success in patients of primary and secondary maxillofacial defects retrospectively.

Methodology: A retrospective study was designed to evaluate the patients of maxillofacial abnormalities repaired using temporalis myofascial flaps during the period of 2008 and 2017. Data regarding demographics, diagnosis of the disease made, site of disease involved, treatment done, outcome and short-term complication were extracted from the past patient records.

Lumazine Synthase Nanoparticles as a Versatile Platform for Multivalent Antigen Presentation and Cross-Protective Coronavirus Vaccines.

Lumazine synthase (LS), a bacterial protein that self-assembles into 60-mer icosahedral virus-like nanoparticles, has emerged as a promising platform for nanoparticle-based drug delivery and vaccine design. However, detailed biophysical characterization of the LS nanoparticle vaccine has not been well-studied. In this study, we generated LS nanoparticles fused with domain B of protein A (pA-LS), enabling their binding to the hFc-tagged S1 domain of the SARS-CoV-2 spike protein harboring two critical mutations (E484K and D614G) associated with increased infectivity and antibody escape.

DBA-ViNet: an effective deep learning framework for fruit disease detection and classification using explainable AI.

Objective: The primary aim of this research is to develop an effective and robust model for identifying and classifying diseases in general fruits, particularly apples, guavas, mangoes, pomegranates, and oranges, utilizing computer vision techniques.

Material: An open-source collection of fruit disease images, comprising both diseased and healthy samples from the first five fruit types, was used in this study. The data was split into 70% training, 15% validation, and 15% testing.

"Comparison among 3 maxillomandibular fixation techniques for management of mandibular fractures - A prospective randomized study".

Background: The Erich arch bar has been a traditional method for maxillomandibular fixation (MMF) in the closed management of mandibular fractures, but it presents significant disadvantages, including prolonged placement time, increased risk of operator injury, and compromised oral hygiene. To address these challenges, alternative methods such as IMF screws and hybrid arch bars have been introduced.

Purpose: This study aimed to compare the efficacy, advantages, disadvantages, and potential complications of three MMF techniques, IMF screws, hybrid arch bars, and Erich arch bars in the management of mandibular fractures.

Photocatalytic Anticancer Activity of Cyclometalated Ir(III) Complexes: A Mechanistic Insight.

Three novel cyclometalated Ir(III) complexes, Ir1-Ir3, were synthesized and thoroughly characterized. These complexes exhibited absorption in the 350-480 nm range, making them suitable candidates for visible-light-mediated photocatalytic cancer therapy. Under visible-light exposure in a DMSO:PBS (1:99 v/v) solvent system, all three photocatalysts demonstrated high efficiency in facilitating NADH oxidation, attaining turnover frequencies (TOFs) in the range of 499-698 h⁻, exceeding the performance of most of the previously reported Ir(III)-based photocatalysts.

Outcomes of Using 3D-Printed Titanium Implants in Mandibular Reconstruction.

Background: Mandibular reconstruction is a critical procedure in the management of defects caused by trauma, tumors, or congenital anomalies. Traditional methods often face challenges such as poor fit, extended surgery time, and postoperative complications. The advent of 3D printing technology allows for the precise fabrication of titanium implants tailored to individual anatomy.

Assessment of AI-Driven Software Accuracy in Diagnosing Oral Lesions Using Radiographic Imaging.

Background: The application of artificial intelligence (AI) in dentistry has gained significant attention, particularly in diagnosing oral lesions using radiographic imaging.

Materials And Methods: A total of 150 digital radiographic images of patients with suspected oral lesions were analyzed. The dataset was split into training (70%) and testing (30%) subsets for the AI model.

Risk factors for asthma across India: Results from global asthma network (GAN) phase I study.

Introduction: This study aimed to assess the risk factors and triggers predisposing to asthma in Indian children and adults.

Methods: The Global Asthma Network Phase I study was a multicentre, international, school, and questionnaire-based cross-sectional study conducted across the world with nine centers in India from 2017-18, the current study being analysis of the Indian data.

Results: There were 20084 children, 25887 adolescents, and 81296 adults from 9 sites across India.

Naringenin attenuates hepato-nephrotoxicity induced by aluminum nanoparticles through the mitigation of oxidative stress and apoptosis.

Background: Aluminum nanoparticles (Al-NPs) are produced by the biodegradation of naturally occurring aluminium metal which can induce physiological toxicities. Naringenin (NAR) is a natural flavonoid possessing therapeutic properties, particularly encountering the toxicity associated with heavy metals.

Methods: This study assessed the effects of NAR on Al-NPs-induced hepato-renal toxicity on mice exposed to Al-NPs (6 mg/kg b.

Role Of Tumescent Solution In Modification Of The Orthognathic Surgery: A Pilot Study.

Introduction: Orthognathic surgery is the most acceptable means for the correction of dentofacial deformities in terms of its outcome and safety. Conventional way of orthognathic surgery constitutes longer operative hours, intraoperative blood loss, and prolonged post-op stay. The last decade has seen a significant change in transforming the conventional standards to outpatient settings through improved surgical techniques.

Enhancing Temporomandibular Joint Surgical Outcomes with Digital Technologies.

This article comprehensively overviews various digital technologies used in temporomandibular joint (TMJ) surgery and their subsequent impact on surgical outcomes. It elaborates on the current techniques for integrating digital technology into TMJ procedures, supported by the evidence of its application in various clinical scenarios and ongoing debates about its effectiveness. Furthermore, the article highlights significant barriers to the global adoption of these technologies, recent notable advancements, and prospective developments that could shape the future of surgical practice in managing TMJ disorders.

Albumin infusion in hepatorenal syndrome-acute kidney injury: New evidence challenges recent consensus.

Recent consensus guidelines by the ADQI (Acute Disease Quality Initiative) and the ICA (International Club of Ascites) put forth recommendations for the management of acute kidney injury (AKI) in cirrhosis, including hepatorenal syndrome-AKI. These recommendations included the use of crystalloids over albumin for first-line volume resuscitation and restricting the use of albumin infusion to 24 h. Whilst based on sound scientific rationale, recent evidence challenges these positions.

Ferrocene conjugated Os(II) complex for photo-catalytic cancer therapy of triple-negative breast cancer cells.

A novel ferrocene-conjugated bimetallic Os(II) photocatalyst (OsFe) showed micromolar photocatalytic anticancer activity against triple-negative breast cancer cells NADH oxidation and caspase 3 activation under visible light.

Post COVID Condition and Long-Term COVID-19 Impact on Hepatic Decompensation and Survival in Cirrhosis: A Propensity Matched Observational Study.

Aims: Patients with cirrhosis are susceptible to decompensation events, including ascites, variceal bleeding (VB), hepatic encephalopathy, or death after COVID-19 infection. Patients may experience post-COVID condition (PCC) with multisystem involvement that persists for at least 2 months.

Methods: Hospitalized patients with cirrhosis and COVID-19 between January 2021 and January 2023 were assessed for decompensation events and mortality and compared to a propensity-matched cohort of cirrhosis and non-COVID-19 sepsis.

Gut commensals-derived succinate impels colonic inflammation in ulcerative colitis.

Gut microbiota-derived metabolites play a crucial role in modulating the inflammatory response in inflammatory bowel disease (IBD). In this study, we identify gut microbiota-derived succinate as a driver of inflammation in ulcerative colitis (UC) by activating succinate-responsive, colitogenic helper T (Th) cells that secrete interleukin (IL)-9. We demonstrate that colitis is associated with an increase in succinate-producing gut bacteria and decrease in succinate-metabolizing gut bacteria.

Mammaglobin negative secretory carcinoma of salivary gland--a diagnostically challenging case report.

Secretory carcinoma, impacting the salivary gland, embodies a low-intermediate grade malignancy characterized by the propensity for local dissemination. The fourth edition of the 2017 head and neck World Health Organization's repertoire has recently integrated SC of the salivary gland into its classification scheme. We aim to delve into a case involving a 35-year-old female presenting with swelling on the left side of her face, persisting for the past 12 years, and exhibiting a negative mammaglobin status.

Solitary fibrous tumor of temporal and infratemporal region: A case report and review of rare entity.

Solitary fibrous tumor (SFT) is a rare, benign spindle-cell neoplasm initially thought to be of mesothelial origin but later recognized as mesenchymal. While uncommon in the head and neck region, SFTs typically present in the oral cavity, orbit, and paranasal sinuses. The tumor's imaging characteristics, such as those seen in ultrasound and MRI, can often mimic vascular lesions, leading to diagnostic challenges.

Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set in 2004 on ACLF was published in 2009, and the "APASL ACLF Research Consortium (AARC)" was formed in 2012.

Influences of aqua-(2-formylbenzoato) triphenyltin(IV) on regression of hypoxic solid tumor through mitochondrial mediated pathway by inhibiting Hif-1 alpha.

Tumor hypoxia is the major hindrance behind cancer chemotherapy and the foremost reason for the less effectiveness of most anticancer drugs. We herein inquire into the mechanistic part and therapeutic efficacy of our previously reported compound, aqua-(2-formylbenzoato) triphenyltin (IV) (abbreviated as OTC), in a hypoxic solid tumor-bearing mouse model (BALB/c). In addition to solid tumors, we investigated the therapeutic potential of OTC in intraperitoneal tumor and in in vitro system.

Synergistic combination of doxorubicin with fisetin for the treatment of lymphoma.

Lymphoma is a common cancer of the lymphatic system, and its treatment presents considerable clinical difficulties due to the constraints of existing medicines. Anticancer drug such as Doxorubicin (DOX) is an effective chemotherapeutic drug that is frequently used to treat lymphoma and other cancers; however, it is linked with considerable toxicities. Fisetin, a naturally occurring flavonoid, exhibits anticancer properties and has the potential to augment the therapeutic effects of DOX.

Proteomics-guided Biomarker Discovery, Validation, and Pathway Perturbation in Infection-related Acute Decompensation of Cirrhosis.

Background & Aims: Inappropriate treatment of infections fuels drug resistance, organ failures, and costs in cirrhosis. We explored proteomics to improve infection diagnosis and management in acutely decompensated (AD) cirrhosis.

Methods: We enrolled 391 patients with AD cirrhosis (92% males, median-age: 41 years), 84 in the discovery cohort (54 infected, 30 non-infected), 147 in the validation cohort I (106 infected, 41 non-infected), and 160 in the validation cohort II (108 infected, 52 non-infected).

Chitosan-Functionalized Fluorescent Calcium Carbonate Nanoparticle Loaded with Methotrexate: Future Theranostics for Triple Negative Breast Cancer.

Herein, fluorescent calcium carbonate nanoclusters encapsulated with methotrexate (Mtx) and surface functionalized with chitosan (25 nm) (@Calmat) have been developed for the imaging and treatment of triple-negative breast cancer (TNBC). These biocompatible, pH-sensitive nanoparticles demonstrate significant potential for targeted therapy and diagnostic applications. The efficacy of nanoparticles (NPs) was evaluated in MDA-MB-231 TNBC cell lines.