Enhancement of Inpatient Mortality Prognostication With Machine Learning in a Prospective Global Cohort of Patients With Cirrhosis With External Validation.

Background & Aims: Cirrhosis is a major global burden requiring frequent hospitalizations and has high inpatient mortality. Traditional prognostic tools focused on inpatient mortality are affected by global disparities, which impacts timely management. We aimed to deploy machine learning (ML) approaches to enhance inpatient mortality prognostication.

Emerging trends in transgene-free crop development: insights into genome editing and its regulatory overview.

Genome editing tools have revolutionized plant biology research offering unparalleled applications for genome manipulation and trait improvement in crops. Adopting such advanced biotechnological tools is inevitable to meet increasing global food demand and address challenges in food production, including (a)biotic stresses and inadequate nutritional value. Despite reliance on conventional genetic manipulation methods, the CRISPR-Cas-mediated genome editing toolbox allows precise modification of DNA/RNA in a target organism's genome.

Role of vitamin D supplementation and vitamin D receptor in drug-resistant epilepsy: A double-blind placebo-controlled trial conducted in India.

Objective: Vitamin D has demonstrated potential anticonvulsant effects in experimental and pilot clinical studies; the results of these remain inconclusive. This study aims to investigate the efficacy and safety of adjunctive Vitamin D supplementation in reducing seizure frequency, modulating vitamin D receptor (VDR) activity, and altering the putative biomarkers of epileptogenesis in persons with drug-resistant epilepsy (DRE).

Methods: This double-blind, placebo-controlled, parallel-group, adjunctive trial recruited patients from a tertiary care hospital in India.

Vitamin D: recent advances, associated factors, and its role in combating non-communicable diseases.

The field of nutrigenomics has produced numerous studies indicating the impact of vitamin D on various disease conditions. Trace elements of this vitamin in the body play a significant role in the regulation of body metabolism. This immunomodulatory vitamin plays a role in management of both communicable (viz.

The impact of leptin receptor (LepR) mutation on the development of MASLD in a murine model.

Genes play an important role in regulating insulin signaling, adipokines, oxidative stress, lipid metabolism, and inflammation in susceptibility and progression of Metabolic dysfunction-associated steatotic liver disease (MASLD). Among various genes, the LepR gene influences insulin sensitivity and controls lipid metabolism, contributing to the development of MASLD. Our previous study reported that a novel congenic mouse (WSB.

Myocardial Infarction Triggered by Marijuana Use.

Chronic marijuana use has been increasingly linked to cardiovascular events, though reports of acute myocardial infarction in young adults without traditional risk factors remain limited. A 24-year-old man with a 9-year history of daily marijuana use presented with acute chest pain. Emergency evaluation revealed anterior ST-segment elevation myocardial infarction with 100% proximal left anterior descending coronary artery occlusion, treated successfully with percutaneous intervention.

Heart on Fire: Unmasking Mutation in Stress-Induced Ventricular Arrhythmias.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmogenic disorder that can lead to sudden cardiac death (SCD) in young individuals with structurally normal hearts. This case report presents a novel instance of CPVT caused by a Ryanodine receptor channel-2 () gene mutation in a young adult. A 24-year-old male presented with recurrent syncope and pre-syncopal episodes.

Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set in 2004 on ACLF was published in 2009, and the "APASL ACLF Research Consortium (AARC)" was formed in 2012.

Bacterial resistance profile and its association with poor outcome among cirrhosis patients attending a tertiary care referral center in northern India.

Background And Objective: The epidemiological connections, predisposing factors and clinical outcomes of infections by drug-resistant bacteria in cirrhosis are poorly documented. Thus, this study was conducted to assess the risk factors, complications and patterns of bacterial resistance among these patients.

Methods: This retrospective observational study was conducted from March 1, 2021, to July 31, 2023, at a tertiary care centre in Uttar Pradesh.

Discussion on "Potential improvement in the mechanical performance and thermal resistance of geopolymer with appropriate microplastic incorporation: A sustainable solution for recycling and reusing microplastics".

We read with great interest the paper by Xie et al. (2024) that describes the methodology for recycling and reusing microplastics, MPs, by utilizing it into the geopolymer, GP, matrix made from fly ash, FA, and ground granulated blast furnace slag, GGBFS. The GP was created by activating the FA and GGBFS (7:3 ratio) using 16 M NaOH.

N-acetyl-L-tryptophan provides radioprotection to mouse and primate models by antagonizing the TRPV1 receptor and substance P inhibition.

Purpose: The present study was carried out to evaluate the radioprotective activities of N-acetyl-L-tryptophan (L-NAT) using rodent and non-human primate (NHP) models.

Materials And Methods: The antagonistic effect of L-NAT on the Transient receptor potential vanilloid-1 (TRPV1) receptor and substance P inhibition was determined using molecular docking and Elisa assays. The in radioprotective activity of L-NAT was evaluated using whole-body survival assays in mice and NHPs.

Seroprotection achieved with standard four-dose schedule of hepatitis B vaccine in people with chronic kidney disease: A real-life data.

Background And Objectives: Hepatitis B virus (HBV) infection is common in people with chronic kidney diseases (CKD). The guidelines recommend four doses, 2.0 mL each, of HBV vaccine, given at zero, one, two and six months in these patients.

Neurocysticercosis: An Uncommon Cause of New-Onset Seizure in the United States.

Neurocysticercosis is predominantly a disease in tropical countries. However, with increasing migration, it is now more frequently reported in developed countries as well. We are reporting a case of new-onset seizures due to underlying neurocysticercosis in a 31-year-old male migrant patient.

Application of fungal inoculants enhances colonization of secondary bacterial degraders during in situ paddy straw degradation: a genomic insights into cross-domain synergism.

Rice cultivation generates huge amounts of on farm residues especially under mechanical harvesting. Paddy straw being recalcitrant hinders sowing of upcoming rabi crops like wheat and mustard. Non-environmental sustainable practice of on-farm burning of the paddy residues is being popularly followed for quick disposal of the agro-residues and land preparation.

Parents's knowledge and awareness about hepatitis B can influence the vaccination of their children.

Background: Birth-dose (Hep-BD) followed by three additional doses (Hep-B3) of hepatitis B virus (HBV) vaccine are key to eliminating HBV by 2030. Unfortunately, Hep-BD and Hep-B3 coverage in our country is poor.

Aim: To studied the parent's knowledge and awareness about HBV infection, its prevention, consequences and vaccination.

Decentralised same day test and treatment of hepatitis C levering existing peer support networks among men who inject drugs: feasibility and effectiveness.

Background: Prevalence of hepatitis C virus (HCV) infection among people who inject drugs in the state of Manipur, India, is 43%; however, access to care is poor. We piloted a Community-led and comprehensive hepatitis care model that included same-day HCV treatment at drug treatment centres.

Methods: Screening was conducted through venipuncture samples collected by community peer PWID, using HCV antibody (HCV Ab) rapid screening and hepatitis B virus (HBV) surface antigen (HBsAg) rapid diagnostic tests.