Publications by authors named "Tieyong Zeng"

An increasing number of publicly available datasets have facilitated the exploration of building universal medical segmentation models. Existing approaches address partially labeled problem of each dataset by harmonizing labels across datasets and independently focusing on the labeled foreground regions. However, significant challenges persist, particularly in the form of cross-site domain shifts and the limited utilization of partially labeled datasets.

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Inspired by neuronal diversity in the biological neural system, a plethora of studies proposed to design novel types of artificial neurons and introduce neuronal diversity into artificial neural networks. Recently proposed quadratic neuron, which replaces the inner-product operation in conventional neurons with a quadratic one, have achieved great success in many essential tasks. Despite the promising results of quadratic neurons, there is still an unresolved issue: Is the superior performance of quadratic networks simply due to the increased parameters or due to the intrinsic expressive capability? Without clarifying this issue, the performance of quadratic networks is always suspicious.

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Accelerating the MRI acquisition process is always a key issue in modern medical practice, and great efforts have been devoted to fast MR imaging. Among them, multi-contrast MR imaging is a promising and effective solution that utilizes and combines information from different contrasts. However, existing methods may ignore the importance of the high-frequency priors among different contrasts.

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Text-guided visual understanding is a potential solution for downstream task learning in echocardiography. It can reduce reliance on labeled large datasets and facilitate learning clinical tasks. This is because the text can embed highly condensed clinical information into predictions for visual tasks.

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In this paper, we propose a new super-expressive activation function called the Parametric Elementary Universal Activation Function (PEUAF). We demonstrate the effectiveness of PEUAF through systematic and comprehensive experiments on various industrial and image datasets, including CIFAR-10, Tiny-ImageNet, and ImageNet. The models utilizing PEUAF achieve the best performance across several baseline industrial datasets.

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Integrating complementary information from multiple magnetic resonance imaging (MRI) modalities is often necessary to make accurate and reliable diagnostic decisions. However, the different acquisition speeds of these modalities mean that obtaining information can be time consuming and require significant effort. Reference-based MRI reconstruction aims to accelerate slower, under-sampled imaging modalities, such as T2-modality, by utilizing redundant information from faster, fully sampled modalities, such as T1-modality.

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Transformer-based image denoising methods have shown remarkable potential but suffer from high computational cost and large memory footprint due to their linear operations for capturing long-range dependencies. In this work, we aim to develop a more resource-efficient Transformer-based image denoising method that maintains high performance. To this end, we propose an Efficient Wavelet Transformer (EWT), which incorporates a Frequency-domain Conversion Pipeline (FCP) to reduce image resolution without losing critical features, and a Multi-level Feature Aggregation Module (MFAM) with a Dual-stream Feature Extraction Block (DFEB) to harness hierarchical features effectively.

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Ultrasound image segmentation is a challenging task due to the complexity of lesion types, fuzzy boundaries, and low-contrast images along with the presence of noises and artifacts. To address these issues, we propose an end-to-end multi-scale feature extraction and fusion network (MEF-UNet) for the automatic segmentation of ultrasound images. Specifically, we first design a selective feature extraction encoder, including detail extraction stage and structure extraction stage, to precisely capture the edge details and overall shape features of the lesions.

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Regularization-based methods are commonly used for image registration. However, fixed regularizers have limitations in capturing details and describing the dynamic registration process. To address this issue, we propose a time multiscale registration framework for nonlinear image registration in this paper.

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Diffusion-weighted imaging (DWI) has been extensively explored in guiding the clinic management of patients with breast cancer. However, due to the limited resolution, accurately characterizing tumors using DWI and the corresponding apparent diffusion coefficient (ADC) is still a challenging problem. In this paper, we aim to address the issue of super-resolution (SR) of ADC images and evaluate the clinical utility of SR-ADC images through radiomics analysis.

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With the widespread application of digital orthodontics in the diagnosis and treatment of oral diseases, more and more researchers focus on the accurate segmentation of teeth from intraoral scan data. The accuracy of the segmentation results will directly affect the follow-up diagnosis of dentists. Although the current research on tooth segmentation has achieved promising results, the 3D intraoral scan datasets they use are almost all indirect scans of plaster models, and only contain limited samples of abnormal teeth, so it is difficult to apply them to clinical scenarios under orthodontic treatment.

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The score-based generative model (SGM) can generate high-quality samples, which have been successfully adopted for magnetic resonance imaging (MRI) reconstruction. However, the recent SGMs may take thousands of steps to generate a high-quality image. Besides, SGMs neglect to exploit the redundancy in space.

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Survival prediction based on histopathological whole slide images (WSIs) is of great significance for risk-benefit assessment and clinical decision. However, complex microenvironments and heterogeneous tissue structures in WSIs bring challenges to learning informative prognosis-related representations. Additionally, previous studies mainly focus on modeling using mono-scale WSIs, which commonly ignore useful subtle differences existed in multi-zoom WSIs.

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Since Magnetic Resonance Imaging (MRI) requires a long acquisition time, various methods were proposed to reduce the time, but they ignored the frequency information and non-local similarity, so that they failed to reconstruct images with a clear structure. In this article, we propose Frequency Learning via Multi-scale Fourier Transformer for MRI Reconstruction (FMTNet), which focuses on repairing the low-frequency and high-frequency information. Specifically, FMTNet is composed of a high-frequency learning branch (HFLB) and a low-frequency learning branch (LFLB).

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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contains information on tumor morphology and physiology for breast cancer diagnosis and treatment. However, this technology requires contrast agent injection with more acquisition time than other parametric images, such as T2-weighted imaging (T2WI). Current image synthesis methods attempt to map the image data from one domain to another, whereas it is challenging or even infeasible to map the images with one sequence into images with multiple sequences.

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Assessments of multiple clinical indicators based on radiomic analysis of magnetic resonance imaging (MRI) are beneficial to the diagnosis, prognosis and treatment of breast cancer patients. Many machine learning methods have been designed to jointly predict multiple indicators for more accurate assessments while using original clinical labels directly without considering the noisy and redundant information among them. To this end, we propose a multilabel learning method based on label space dimensionality reduction (LSDR), which learns common and task-specific features via graph regularized nonnegative matrix factorization (CTFGNMF) for the joint prediction of multiple indicators in breast cancer.

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The Retinex model is one of the most representative and effective methods for low-light image enhancement. However, the Retinex model does not explicitly tackle the noise problem and shows unsatisfactory enhancing results. In recent years, due to the excellent performance, deep learning models have been widely used in low-light image enhancement.

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Purpose: During neoadjuvant chemotherapy (NACT), breast tumor morphological and vascular characteristics are usually changed. This study aimed to evaluate the tumor shrinkage pattern and response to NACT by preoperative multiparametric magnetic resonance imaging (MRI), including dynamic contrast-enhanced MRI (DCE-MRI), diffuse weighted imaging (DWI) and T2 weighted imaging (T2WI).

Method: In this retrospective analysis, female patients with unilateral unifocal primary breast cancer were included for predicting tumor pathologic/clinical response to NACT (n=216, development set, n=151 and validation set, n=65) and for discriminating the tumor concentric shrinkage (CS) pattern from the others (n=193; development set, n=135 and validation set, n=58).

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Recently, deep convolution neural networks (CNNs) steered face super-resolution methods have achieved great progress in restoring degraded facial details by joint training with facial priors. However, these methods have some obvious limitations. On the one hand, multi-task joint learning requires additional marking on the dataset, and the introduced prior network will significantly increase the computational cost of the model.

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The long acquisition time has limited the accessibility of magnetic resonance imaging (MRI) because it leads to patient discomfort and motion artifacts. Although several MRI techniques have been proposed to reduce the acquisition time, compressed sensing in magnetic resonance imaging (CS-MRI) enables fast acquisition without compromising SNR and resolution. However, existing CS-MRI methods suffer from the challenge of aliasing artifacts.

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Scene recovery is a fundamental imaging task with several practical applications, including video surveillance and autonomous vehicles, etc. In this article, we provide a new real-time scene recovery framework to restore degraded images under different weather/imaging conditions, such as underwater, sand dust and haze. A degraded image can actually be seen as a superimposition of a clear image with the same color imaging environment (underwater, sand or haze, etc.

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Discovering hidden pattern from imbalanced data is a critical issue in various real-world applications. Existing classification methods usually suffer from the limitation of data especially for minority classes, and result in unstable prediction and low performance. In this paper, a deep generative classifier is proposed to mitigate this issue via both model perturbation and data perturbation.

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Semantic segmentation has achieved great progress by effectively fusing features of contextual information. In this article, we propose an end-to-end semantic attention boosting (SAB) framework to adaptively fuse the contextual information iteratively across layers with semantic regularization. Specifically, we first propose a pixelwise semantic attention (SAP) block, with a semantic metric representing the pixelwise category relationship, to aggregate the nonlocal contextual information.

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Junction plays an important role in biomedical research such as retinal biometric identification, retinal image registration, eye-related disease diagnosis and neuron reconstruction. However, junction detection in original biomedical images is extremely challenging. For example, retinal images contain many tiny blood vessels with complicated structures and low contrast, which makes it challenging to detect junctions.

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Image denoising is a challenging inverse problem due to complex scenes and information loss. Recently, various methods have been considered to solve this problem by building a well-designed convolutional neural network (CNN) or introducing some hand-designed image priors. Different from previous works, we investigate a new framework for image denoising, which integrates edge detection, edge guidance, and image denoising into an end-to-end CNN model.

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