Comprehensive analysis of genomic loci associated with glaucousness in wheat ( L.) through Genome-wide association study.

Unlabelled: Wheat ( L.) is one of the most important cultivated cereal grain crop. The yield and productivity of wheat are profoundly affected by abiotic stresses like drought.

Genomic Prediction Paves Way for the Identification of Multiple Rust Resistant Genotypes in Bread Wheat ( L.).

Over the past two decades, genomic prediction (GP), also known as genomic selection (GS), has been widely adopted in plant and animal breeding programs worldwide. GP is a promising approach that utilizes genomic markers to estimate genomic-estimated breeding values (GEBVs), facilitating the selection of superior individuals. In this study, we assessed the performance of five GP models- Genomic Best Linear Unbiased Prediction (GBLUP), Reproducing Kernel Hilbert Space regression (RKHS) and Bayesian methods (BayesA, BayesB, and BayesC)-for predicting seedling and adult plant resistance (APR) to leaf/brown rust (LR), stem/black rust (SR), and yellow/stripe rust (YR) in wheat using a panel of 347 diverse germplasm accessions.

Genetic dissection of leaf rust resistance in a diversity panel of tetraploid wheat (Triticum turgidum).

Background: Leaf rust, caused by Puccinia triticina Eriks (Pt) is a major threat to wheat cultivation worldwide. The rapid evolution of this pathogen has led to the emergence of new virulent strains that can overcome the resistance of commonly cultivated wheat varieties. To address this threat, continuous monitoring of leaf rust pathotypes is conducted in wheat-growing regions across the world.

Synthesis and Study of pH Independent L-Cysteine Capped Zirconium Oxide Quantum Dots as a Potential Bio-Imaging Probe Using HeLa Cells.

Here we propose an eco-friendly hydrothermal approach to synthesise fluorescent L-cysteine capped zirconium oxide quantum dots (L-Cys-ZrO QDs). The UV-Vis absorption, PL-emission, pH independence, size, functional group attached over surface QDs, binding energy, and stability of QDs in aqueous solvent were systematically studied. The TEM results revealed the mean particle size ∼5.

Unraveling the genetic basis of heat tolerance and yield in bread wheat: QTN discovery and Its KASP-assisted validation.

Background: Wheat (Triticum aestivum L.), a globally significant cereal crop and staple food, faces major production challenges due to abiotic stresses such as heat stress (HS), which pose a threat to global food security. To address this, a diverse panel of 126 wheat genotypes, primarily landraces, was evaluated across twelve environments in India, comprising of three locations, two years and two growing conditions.

Identification of quantitative trait nucleotides for grain quality in bread wheat under heat stress.

Heat stress is a critical factor affecting global wheat production and productivity. In this study, out of 500 studied germplasm lines, a diverse panel of 126 wheat genotypes grown under twelve distinct environmental conditions was analyzed. Using 35 K single-nucleotide polymorphism (SNP) genotyping assays and trait data on five biochemical parameters, including grain protein content (GPC), grain amylose content (GAC), grain total soluble sugars (TSS), grain iron (Fe), and zinc (Zn) content, six multi-locus GWAS (ML-GWAS) models were employed for association analysis.

Exploring the genetic diversity and population structure of an ancient hexaploid wheat species Triticum sphaerococcum using SNP markers.

Background: Understanding genetic diversity and population structure is crucial for strategizing and enhancing breeding efficiency. Wheat, a globally cultivated crop, is a significant source of daily calories for humans. To overcome challenges such as extreme climatic fluctuations, stagnant yields, and diminishing genetic variation, it is essential to develop diverse germplasms with new alleles.

Do different wheat ploidy levels respond differently against stripe rust infection: Interplay between reactive oxygen species (ROS) and the antioxidant defense system?

Wheat stripe rust (Puccinia striiformis f. sp. tritici, Pst) is the most damaging wheat disease, causing substantial losses in global wheat production and productivity.

Genetic dissection of value-added quality traits and agronomic parameters through genome-wide association mapping in bread wheat ( L.).

Bread wheat ( is one of the world's most widely consumed cereals. Since micronutrient deficiencies are becoming more common among people who primarily depend upon cereal-based diets, a need for better-quality wheat varieties has been felt. An association panel of 154 lines was evaluated for the following quality traits: grain appearance (GA) score, grain hardness (GH), phenol reaction (PR) score, protein percent, sodium dodecyl sulfate (SDS) sedimentation value, and test weight (TWt).

Exploring the genetic architecture of powdery mildew resistance in wheat through QTL meta-analysis.

Powdery mildew (PM), caused by sp. , poses a significant threat to wheat production, necessitating the development of genetically resistant varieties for long-term control. Therefore, exploring genetic architecture of PM in wheat to uncover important genomic regions is an important area of wheat research.

Outcomes in transcatheter aortic valve replacement (TAVR) patients requiring red blood cell transfusion: A nationwide perspective.

Background: Transcatheter aortic valve replacement (TAVR) can be complicated by anemia due to periprocedural bleeding, hemolysis, vascular events, or significant bleeding associated with antiplatelet therapy.

Objective: We used the National Inpatient Sample (NIS) database to study the outcomes of patients who underwent TAVR and developed significant anemia requiring red blood cell (RBC) transfusion.

Methods: This is a retrospective cohort study utilizing the NIS database from 2016 to 2017.

Coronary Artery Aneurysms and Acute Coronary Syndrome: An Interventionalist's Dilemma.

We report three cases of coronary artery aneurysm (CAA) in adults who presented with acute coronary syndrome. Two of these patients did not have traditional coronary artery disease risk factors. Management of CAA poses a significant challenge to interventionalists.

Do diverse wheat genotypes unleash their biochemical arsenal differentially to conquer cold stress? A comprehensive study in the Western Himalayas.

Wheat is one of the most important cereal crops in the world. Cold stress is a major constraint in production of wheat grown in cold climate regions. In this study, we conducted a comprehensive assessment of cold stress tolerance in wheat genotypes through field screening, cell membrane stability through electrolyte leakage assay and biochemical profiling.

PCSK9 Inhibitors - A New Hope for Dyslipidemia in HIV.

Cardiovascular disease has become increasingly prevalent in the HIV population. Antiretroviral therapy and HIV itself independently increase the risk of dyslipidemia. While statins are currently the predominant therapy to treat dyslipidemia in HIV patients, drug-drug interactions and adverse drug events can limit their use.

Meta-QTL analysis in wheat: progress, challenges and opportunities.

Wheat, an important cereal crop globally, faces major challenges due to increasing global population and changing climates. The production and productivity are challenged by several biotic and abiotic stresses. There is also a pressing demand to enhance grain yield and quality/nutrition to ensure global food and nutritional security.

The comparison of the analgesic efficacy of continuous paravertebral block alone compared with continuous paravertebral and intercostal nerve block for thoracotomy in adults: a randomized controlled trial.

Purpose: The study aims to compare the analgesic efficacy of two analgesic interventions, continuous paravertebral (PVB) nerve block alone with continuous paravertebral and intercostal nerve block (PVB/ICB) in patients undergoing thoracotomy.

Methods: A total of 70 patients undergoing thoracotomy were randomly enrolled in either continuous paravertebral nerve block (PVB) group or in continuous paravertebral and intercostal nerve block (PVB/ICB) group and received corresponding blocks. Analgesic efficacy measured by Visual Analog Scale (VAS) pain score, hemodynamic effects, total narcotic consumption, sedation score, patient's length of stay in hospital and patient's satisfaction with the analgesic technique were recorded.

Coronary Orbital Atherectomy Through Newly Deployed Left Main Coronary Stent.

Percutaneous coronary intervention (PCI) in complex, calcified coronary lesions can be assisted with orbital atherectomy (OA). OA is generally avoided when there are lesions amendable to OA distal to a newly deployed stent due to the risk of device-stent interaction, burr entrapment, and stent avulsion. We present a case documenting the successful passage of an OA system through a recently deployed left main stent to prepare a chronically occluded left anterior descending for PCI.

Left Atrial Appendage Closure Outcomes in Patients With Cancer at a Single Tertiary Center.

Atrial fibrillation is the most common arrhythmia in patients with underlying malignancy. Patients with cancer have a higher risk of bleeding, and at the same time, carry an elevated risk of thromboembolism related to the hypercoagulable state, type of cancer, and anticancer treatment, rendering safe anticoagulation challenging in this population. Left atrial appendage closure is an alternative treatment option in patients with atrial fibrillation and high bleeding risk; however, the data on patients with cancer are limited.

Sex-Based Outcomes in Patients Undergoing WATCHMAN Device Implantation.

Sex-based disparities in outcomes are reported for various cardiovascular procedures. This study aimed to assess the difference in outcomes in patients who underwent WATCHMAN device implant based on sex. Patients who underwent WATCHMAN device placement, from 2016 to 2018, were identified from the National Inpatient Sample database.

Identification of Novel QTLs/Defense Genes in Spring Wheat Germplasm Panel for Seedling and Adult Plant Resistance to Stem Rust and Their Validation Through KASP Marker Assays.

Stem rust is one of the major diseases threatening wheat production globally. To identify novel resistance quantitative trait loci (QTLs), we performed 35K Axiom Array SNP genotyping assays on an association mapping panel of 400 germplasm accessions, including Indian landraces, in conjunction with phenotyping for stem rust at seedling and adult plant stages. Association analyses using three genome wide association study (GWAS) models (CMLM, MLMM, and FarmCPU) revealed 20 reliable QTLs for seedling and adult plant resistance.

Comparative transcriptome profiling of near isogenic lines PBW343 and FLW29 to unravel defense related genes and pathways contributing to stripe rust resistance in wheat.

Stripe rust (Sr), caused by Puccinia striiformis f. sp. tritici (Pst), is the most devastating disease that poses serious threat to the wheat-growing nations across the globe.

Comprehensive meta-QTL analysis for dissecting the genetic architecture of stripe rust resistance in bread wheat.

Background: Yellow or stripe rust, caused by the fungus Puccinia striiformis f. sp. tritici (Pst) is an important disease of wheat that threatens wheat production.

Role of Mechanical Circulatory Support in Acute MI Management.

Cardiogenic shock complicating acute MI carries high mortality and morbidity in many cases. Mechanical circulatory support devices are often used in these cases, aimed at improving patient-centered outcomes, although there is a lack of large randomized clinical trial-based evidence for many of such devices. Various circulatory support devices are available with their associated risks and benefits.