Publications by authors named "Songping Cui"
Background: Due to the poor prognosis of non-small cell lung cancer (NSCLC) patients, precise and reliable biomarkers are urgently needed to predict the prognosis in NSCLC patients after radical lung surgery. Hence, this study sought to investigate the correlation between the monocyte-to-high-density lipoprotein ratio (MHR) and overall survival (OS) in NSCLC patients after surgery.
Methods: This retrospective study analyzed clinical data, including MHR, from NSCLC patients undergoing radical surgery.
Background: Venous thromboembolism (VTE) is a common postoperative complication in oncologic surgery, closely associated with perioperative hypercoagulability. Thromboelastography (TEG) may be an effective method for monitoring hypercoagulability and guiding preventive anticoagulation.
Methods: We prospectively collected perioperative clinical data from lung cancer surgery patients at our hospital between June 2019 and January 2020.
Background: Inflammatory biomarkers have shown prognostic value in Non-Small Cell Lung Cancer (NSCLC), but the inclusion of Adenocarcinoma (AIS) cases in previous studies may introduce bias. This study aims to evaluate the prognostic significance of inflammatory biomarkers in NSCLC while excluding AIS.
Methods: This study included patients who received surgery for lung carcinoma from August 2016 and August 2019.
Background: Perioperative inflammatory indices reflect systemic inflammatory responses and have been linked to cancer progression and prognosis. This study aims to explore the differences in perioperative inflammatory indices between lung squamous cell carcinoma (LSCC) and adenocarcinoma (LUAD) and their association with long-term outcomes.
Methods: This study included 287 lung cancer patients who underwent curative resection between June 2016 and December 2017, comprising 61 cases of LSCC and 226 cases of LUAD.
Neutrophil count and reduced risk of venous thromboembolism: a Mendelian randomization study.
Hematology
December 2024
Article Synopsis
- The study explored the relationship between blood cell traits, especially neutrophils, and venous thromboembolism (VTE) using genetic data from over 173,000 individuals.
- Researchers utilized various methods, including Mendelian randomization, to analyze genetic variants and their influence on VTE, incorporating data from a larger cohort of nearly 377,000 individuals.
- The findings revealed that higher neutrophil counts are associated with a reduced risk of VTE, suggesting potential avenues for future prevention and treatment strategies for this condition.
Article Synopsis
- Microwave ablation (MWA) is a treatment for lung cancer that lacks standardized power selection guidelines; this study investigates its effectiveness and safety at varying power levels.
- The research included 265 patients divided into low power (192) and high power (73) groups, revealing that the high power group had more postoperative complications but better overall and disease-free survival rates.
- Key factors influencing patient outcomes were identified, leading to the development of a nomogram that can predict survival rates, suggesting a potential for personalized treatment strategies despite increased risks with high-power MWA.
Background: Sinistral portal hypertension (SPH) may occur in patients with pancreatic carcinoma after pancreaticoduodenectomy (PD) with spleno-mesenterico-portal (S-M-P) confluence resection. This study aimed to evaluate outcomes with bifurcated allogeneic vein replacement in the prevention of SPH in pancreatic carcinoma patients.
Materials And Methods: A total of 81 patients were included.
Background: The preoperative inflammatory condition significantly influences the prognosis of malignancies. We aimed to investigate the potential significance of preoperative inflammatory biomarkers in forecasting the long-term results of lung carcinoma after microwave ablation (MWA).
Method: This study included patients who received MWA treatment for lung carcinoma from Jan.
Immunotherapy resistance conducts the main reason for failure of PD-1-based immune checkpoint inhibitors (ICIs) in patients with hepatocellular carcinoma (HCC). This study aims to clarify the mechanism of nature kill cells (NK) depletion in immunotherapy resistance of HCC. Cancerous /paracancerous tissues and peripheral blood (PB) of 55 HCC patients were collected and grouped according to differentiation degree, FCM, IHC and lymphocyte culture drug intervention experiments were used to determine NK cell depletion degree.
View Article and Find Full Text PDFBackground: Portal vein thrombosis (PVT) is a common postoperative complication in patients with pancreatic cancer (PC), significantly affecting their quality of life and long-term prognosis. Our aim is to establish a new nomogram to predict the risk of PVT after PC surgery.
Method: We collected data from 416 patients who underwent PC surgery at our hospital between January 2011 and June 2022.
Allogeneic Vessels in Pancreaticoduodenectomy with Portal Vein Resection: Risk of Portal Vein Thrombosis and Prognosis.
J Gastrointest Surg
December 2023
Background: Allogeneic vessels (AV) are commonly used in pancreaticoduodenectomy (PD) with portal vein resection (PVR), but the epidemiological characteristics of portal vein thrombosis (PVT) are still unclear.
Methods: The clinicopathological data of patients who underwent PD combined with PVR in our hospital from January 2011 to October 2022 were retrospectively collected. All patients underwent regular contrast-enhanced CT of the abdomen after surgery to identify PVT or recurrence and metastasis of the tumor.
Article Synopsis
- The study focuses on pancreatic ductal adenocarcinoma (PDAC), aiming to analyze the role of coagulation-related genes and immune cell infiltration in patients.
- Researchers categorized PDAC patients into clusters based on coagulation pathways, revealing differences in genomic features and immune responses among the clusters.
- A prognostic model was developed to predict patient risk and response to immunotherapy, and the study confirmed findings using samples from actual PDAC patients.
Background: To investigate the clinical significance of preoperative inflammatory status in patients with pancreatic head carcinoma (PHC), we performed a single-center study to assess it.
Method: We studied a total of 164 patients with PHC undergoing PD surgery (with or without allogeneic venous replacement) from January 2018 to April 2022. Systemic immune-inflammation index (SII) was the most important peripheral immune index in predicting the prognosis according to XGBoost analysis.
Background: The purpose was aimed to evaluate the safety and effectiveness of cholecystic duct plasty (CDP) and biliary reconstruction techniques preventing biliary complications following orthotopic liver transplantation (OLT) first proposed by our center.
Methods: 127 enrolled patients who underwent LT in our center from January 2015 to December 2019 were analyzed retrospectively. According to the mode of biliary tract reconstruction, patients were divided into CDP group (Group 1, = 53) and control group (Group 2, = 74).
Background: Preoperative inflammatory status plays an important role in the prognosis of malignancy. We sought to explore the value of preoperative inflammatory biomarkers in predicting long-term outcomes of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC).
Method: Patients who underwent LT for HCC in our hospital between January 2010 and June 2020 were included in this study.
Article Synopsis
- The study focuses on improving the prognosis and treatment options for patients with distal cholangiocarcinoma (dCCA) using machine learning models.
- Researchers analyzed data from 169 patients, dividing them into training and validation cohorts to evaluate various machine learning techniques such as support vector machine (SVM) and random survival forests (RSF).
- Five key medical features were identified that contributed to effective model predictions, with the goal of optimizing patient treatment and outcomes based on postoperative chemotherapy benefits.
Background: To investigate venous thromboembolism (VTE) in patients undergoing distal cholangiocarcinoma (dCCA) surgery, we performed a single-center study to assess its prevalence, risk factors, prognosis.
Method: We studied a total of 177 patients undergoing dCCA surgery from January 2017 to April 2022. Demographic, clinical data, laboratory data (including lower extremity ultrasound findings), and outcome variables were obtained, and compared between VTE and non-VTE groups.
Background: With the advancement of vascular anastomosis techniques in recent years, radical surgery for tumors combined with venous vascular resection and reconstruction has been widely used. This study intends to establish two different rat vein replacement models, and further analyze the pathological changes of blood vessels after replacement.
Methods: Brown-Norway (BN) rats were selected as donors and recipients, randomly divided into control group, cuff group (1-week group, 2-week group, and 4-week group), and suture group (1-week group, 2-week group, and 4-week group), with 6 rats in each group.
Background And Objectives: Lung cancer patients slated for surgery are at high risk of venous thromboembolism (VTE). Precise risk assessment is necessary for providing proper thromboprophylaxis and reducing morbidity and mortality of VTE.
Methods: A multicenter, observational, cross-sectional cohort study, involving patients with primary lung cancer undergoing surgery, was carried out from August 2016 to December 2019.
Background: There is a high incidence of venous thromboembolism (VTE) after lung resection, so it is necessary to identify the risk factors for VTE in these patients. It is also important to evaluate whether the modified Caprini score can accurately assess the risk of VTE in patients after lung resection.
Methods: This retrospective study included 437 patients undergoing lung resection between July 2016 and December 2017.
Background: Venous thromboembolism (VTE) occurs at a high rate after lung cancer surgery and can be attributed to various clinical risk factors. Here, we aimed to determine whether early detection of perioperative D-dimer and risk-stratified cutoff values would improve the diagnostic efficacy of VTE.
Methods: In this case-control study, D-dimer results were acquired from 171 non-small cell lung cancer (NSCLC) patients preoperatively and at the first, third, and fifth day after surgery.
Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia.
J Thromb Haemost
June 2020
Background: Three months ago, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is still rarely mentioned.
Objectives: To determine the incidence of VTE in patients with severe NCP.