Stable Ultrabroad-Absorbing Radical Achieves Efficient NIR-II Photothermal Conversion via Facile Synthesis.

Inspired by the electron-withdrawing ability of nitroxide radicals, a novel open-shell material, EDOT-TPAO is reported, synthesized via one-step demethylation and oxidation of its closed-shell precursor, EDOT-TPAOMe. Time-dependent density functional theory calculations confirm an acceptor-donor-acceptor configuration of EDOT-TPAO where radical termini act as electron acceptors. This structural transformation narrows the optical bandgap from 2.

Metabolic Mechanism of Qizhi Capsule for Treating Hyperlipoidemia Based on Chinmedomics Strategy.

To elucidate the active ingredients, and mechanism of action of Qizhi Capsules (QZC), a traditional Chinese patent medicine for the treatment of hyperlipidemia (HP). A high-fat diet-induced HP rat model was used to evaluate the therapeutic effect of QZC. Then, we integrated metabolomics, serum pharmacochemistry, network pharmacology, and molecular docking strategies for investigation.

Light-triggered molecular mechanotherapy of tumor using membrane-mimicking conjugated oligoelectrolytes.

A class of light-mediated mechanotherapeutic agents was developed on the basis of conjugated oligoelectrolytes (COEs), which mimic the topology of lipid membranes and intrinsically exhibit excellent biocompatibility. Low-dose white light irradiation (20 milliwatts per square centimeter for 10 minutes) substantially decreased the half-maximal inhibitory concentration of the optimized COE against A549 cancer cells from more than 256 to 0.6 micromolar.

Cost-Effective Magnetic LDHs for Simultaneous Sludge Dewatering and Phosphorus Recovery: A Scalable Approach for Municipal Wastewater Plants.

Phosphorus recovery from municipal sludge is essential to reduce environmental pollution and address the global phosphorus crisis. This study introduces a magnetic Fe/Mg/Zn-layered double hydroxide (LDH) composite for simultaneous phosphorus recovery and sludge dewatering from municipal wastewater. The synthesized composite exhibits a high phosphorus adsorption capacity of 25.

Turning Waste into Treasure: Pretreatment Strategy for Promoting Secondary Grain Growth by Reusing Excess Lead Iodide in Perovskite Solar Cells.

Perovskite solar cells have witnessed remarkable progress in recent years, yet several pivotal factors persistently impede their widespread commercial adoption. Among these, the behavior of excess lead iodide (PbI) during perovskite synthesis is particularly concerning. Excess PbI that promotes perovskite growth will accumulate at grain boundaries during annealing, which restricts the device performance and hinders its long-term applicability.

Mode-Specific Quantum and Quasi-Classical Trajectory Dynamics of the F + CHI → I + CHF S2 Reaction.

Bimolecular nucleophilic substitution (S2) reactions in the gas phase are of great importance in chemistry, whose microscopic mechanisms are, however, not comprehensively understood. In this work, the mode-specific quantum dynamics of the prototypical S2 reaction F + CHI → I + CHF are investigated using reduced six-dimensional quantum wave packet and full-dimensional quasi-classical trajectory methods. The reaction probabilities are calculated for both the ground and excited vibrational states of the reactant CHI at collision energies up to 2.

A three-dimensional Pt@Ti₃C₂Tₓ-based smart platform for discrimination of hydrated ammonia in multi-scenario environmental monitoring.

Portable smart gas sensors are vital for hazardous gas monitoring, with ammonia (NH) sensors playing a key role in contamination tracking across agriculture, industry, and storage systems. However, precise detection of hydrated NH (NH·HO), the dominant form in humid environments, remains a significant yet often overlooked challenge due to fluctuating coexistence of multiple ammonia species, compounded by nonselective reactions and poor humidity tolerance in current sensors. Herein, a sensing platform by integrating highly active Pt catalysts into a 3D hollow spherical TiCT framework is presented.

Time-Frequency Domain NO-Humidity Sensor with Full-Range Tolerance Based on Pt Single-Atom Sensitized NbCT Nanosheets.

Real-time in situ detection of NO is crucial for ensuring industrial safety and healthcare. However, conventional gas sensors face challenges from environmental humidity interference, limiting their reliability in practical applications. This study presents a dual-mode, full-range NO-humidity sensing platform based on Pt single-atom-sensitized NbCT nanosheets (Pt SA-NbCT) integrated with TPU fiber mats (Pt SA-NbCT@TPU).

Novel insights into myocardial fibrosis in patients with new onset ST-elevation myocardial infarction following percutaneous coronary intervention through enhanced cardiac magnetic resonance imaging: a prospective cohort study.

Background: Myocardial fibrosis is a prevalent pathological hallmark of a diverse range of chronic and acute cardiovascular disorders. However, the relevant literature currently provides limited evidence regarding the determinants of myocardial fibrosis severity in patients with new-onset ST-elevation myocardial infarction (STEMI) following successful emergent percutaneous coronary intervention (PCI) utilizing contrast-enhanced cardiac magnetic resonance imaging (CE-CMR).

Methods: We prospectively enrolled a cohort of 78 patients who presented with new-onset ST-segment elevation myocardial infarction and who underwent successful emergent PCI within 12 h from the onset of symptoms.

Efficient and Super-Stable 990 Nm Light‑Emitting Diodes Based on Quantum Cutting Emission of Trivalent Ytterbium in Pure-Br Quasi‑2D Perovskites.

Quasi 2D layered metal halide perovskites (2D-LMHPs) with natural quantum wells (QWs) structure have garnered significant attention due to their excellent optoelectronic properties. Doping rare earth (RE) ions with 4f inner shell emission levels can largely expand their optical and optoelectronic properties and realize diverse applications, but has not been reported yet. Herein, an efficient Yb-doped PEACsPbBr quasi 2D-LMHPs is fabricated and directly identified the Yb ions in the quasi 2D-LMHPs at the atomic scale using aberration electron microscopy.

Photoinduced stepwise charge hopping in π-stacked perylene bisimide donor-bridge-acceptor arrays.

The mechanistic understanding of light-driven charge separation and charge-carrier transport within the frameworks of π-conjugated molecules is imperative to mimic natural photosynthesis and derive synthetic materials for solar energy conversion. In this regard, since the late 1980s, the distance and solvent dependence of stepwise (incoherent) charge-carrier hopping versus single-step (coherent) superexchange transport (tunnelling) have been studied in detail. Here we introduce structurally highly defined cofacially stacked donor-acceptor perylene bisimide arrays, which offer a high resemblance to natural systems.

Revealing a Heavy-Atom Assisted Rotation Mechanism in the H + NHCl Multi-Channel Reaction.

Identifying atomic-level mechanisms in elemental chemical reactions is crucial for understanding complex reaction processes. This study focuses on the typical multichannel H + NHCl reaction, which plays a significant role in environmental science. High-level ab initio calculations determined seven distinct reaction pathways, leading to three product channels: H + NHCl, HCl + NH, and Cl + NH.

A dynamic isotope effect in the nucleophilic substitution reaction between F and CDI.

The influence of quantum mechanics on the dynamics of chemical reactions is unknown for many processes in chemistry. Chemical reaction dynamics are often well described by quasiclassical motion of the atoms on quantum mechanical Born-Oppenheimer potential energy surfaces. Here we present a dynamic isotope effect in a nucleophilic substitution reaction experiment that can only be explained by quasiclassical trajectory simulations for reactants containing deuterium atoms, but not when hydrogen atoms are involved.

Fingerprint Profile Analysis of Polypeptide Based on UHPLC-MS and Its Application.

As a medicinal and food homologous substance, is renowned for its potential health benefits, including anti-tumor effects, immune system support, and anti-inflammatory properties. polypeptides have demonstrated significant biological activity, including the regulation of coagulation and lipid metabolism. However, the peptide composition of requires further clarification to facilitate quality control improvements and a deeper investigation into its pharmacological effects.

Bio-Inspired Self-Assembly of Enzyme-Micelle Systems for Semi-Artificial Photosynthesis.

Supramolecular surfactants provide a versatile platform to construct systems for solar fuel synthesis, for example via the self-assembly of amphiphilic photosensitizers and catalysts into diverse supramolecular structures. However, the utilization of amphiphilic photosensitizers in solar fuel production has predominantly focused on yielding gaseous products, such as molecular hydrogen (H), carbon monoxide (CO), and methane (CH) with turnover numbers (TONs) of synthetic catalysts typically in the range of hundreds to thousands. Inspired by biological lipid-protein interactions, we present herein a bio-hybrid assembly strategy that utilizes photosensitizers as surfactants to form micellar scaffolds that interface with enzymes, namely hydrogenases and formate dehydrogenases, for semi-artificial photosynthesis.

Predicting Rate Constants of Hydrogen Abstraction Reactions between OH/HO and Alkanes by Machine Learning Models.

The hydrogen abstraction reactions by small radicals from fuel molecules play an important role in the oxidation of fuels. However, experimental measurements and/or theoretical calculations of their rate constants under combustion conditions are very challenging due to their high reactivity. Machine learning offers a promising approach to predicting thermal rate constants.

Validation of a Novel Strategy for Fluorescence Quenching for a Self-Quenching Fluorogenic Probe and Its Application for Visual Loop-Mediated Isothermal Amplification Detection During Food Safety Analysis.

The self-quenching fluorogenic probe facilitates precise identification of LAMP (loop-mediated isothermal amplification) amplicons, unaffected by non-specific products resulting from primer dimers. However, low quenching efficiency by surrounding nucleobases leads to high background signal, posing significant challenges for visual inspection with the naked eye. The present study aims to identify an oligonucleotide sequence that is complementary to the self-quenching fluorogenic probe, and to employ the fluorescence super-quenching mechanism of double-stranded DNA to establish a visualization system for the LAMP assay.

A multiband NIR upconversion core-shell design for enhanced light harvesting of silicon solar cells.

Exploring lanthanide light upconversion (UC) has emerged as a promising strategy to enhance the near-infrared (NIR) responsive region of silicon solar cells (SSCs). However, its practical application under normal sunlight conditions has been hindered by the narrow NIR excitation bandwidth and the low UC efficiency of conventional materials. Here, we report the design of an efficient multiband UC system based on Ln/Yb-doped core-shell upconversion nanoparticles (Ln/Yb-UCNPs, Ln= Ho, Er, Tm).

Exploring heparin's protective mechanism against AGEs induced endothelial injury.

Advanced glycation end products (AGEs) in diabetes can cause endothelial damage. Heparin, widely known as a recognized anticoagulant, is also a multifunctional therapeutic drug. This study investigated whether heparin could ameliorate AGEs-induced endothelial injury.

Rate Constants of the H + HCF → H + CF Reaction from Ring Polymer Molecular Dynamics on a Highly Accurate Potential Energy Surface.

The reaction between H and HCF is the primary consumption pathway of HCF in the atmosphere and combustion. In this work, ring polymer molecular dynamics (RPMD) calculations are performed to calculate the rate constants of the reaction on a recently developed accurate potential energy surface. 36, 20, and 8 beads are used to compute the rate constants at 350 K ≤ < 800 K, 800 K ≤ ≤ 1000 K, and > 1000 K, respectively.

A Novel Method for Rapid Screening of Salmonidae Ingredients and Accurate Detection of Atlantic Salmon () Simultaneously Using Duplex Real-Time PCR Coupled with Melting Curve Analysis.

The substitution of ingredients with Salmonidae, particularly , has led to widespread reports of financial losses and health risks globally, emphasizing the urgent need for the development of a rapid and precise method for species identification. The aim of the present study was to develop a novel method for the rapid screening of Salmonidae ingredients and the accurate detection of simultaneously using multiplex real-time PCR coupled with melting curve analysis. Specifically, primer sets specific for and Salmonidae were cross-confirmed.

A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three-Dimensionally Conductive MOF Network for Gas and Pressure Sensing.

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine healthcare. Meticulously building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external stimuli. However, realistic mimesis, both in the skin's three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities, remains a challenging yet vital need for simplifying the design of flexible logic circuits.

Quaternary Ammonium Salt-Based Intrinsic Antibacterial Polyurethanes: Optimizing the Antibacterial Activity via Cationic Main- or Side-Chain Design in Hard Segments.

Thermoplastic polyurethanes (TPUs) are one of the most appealing materials with extensive applications in biomedical fields due to their versatile mechanical properties and excellent biocompatibility. In response to the escalating challenges of bacterial infections, it is desirable to obtain TPUs with intrinsic antibacterial activity, particularly for application in biomedical devices and public places. Herein, a cationic main-/side-chain structure regulation strategy in the TPU hard segment was adopted to introduce and optimize the antibacterial activity.

Empagliflozin alleviates obesity-related cardiac dysfunction via the activation of SIRT3-mediated autophagosome formation.

Background: Empagliflozin (EMPA) has demonstrated efficacy in providing cardiovascular benefits in metabolic diseases. However, the direct effect of EMPA on autophagy in obesity-related cardiac dysfunction remains unclear. Therefore, this study aimed to determine changes in cardiac autophagy during diet-induced obesity and clarify the exact mechanism by which EMPA regulates autophagic pathways.